Based on quality function deployment (QFD) and emotional design theory, the psychological needs of users are explored, and the interactive design system of office chairs is developed centering on users, thus solving the problems of space efficiency, office mode and human-computer interaction. First of all, through the relationship between the emotional concept and “function-behavior-benefit” in QFD method, from the perspective of emotional experience, the man-machine relationship is analyzed, and the principles and methods of contemporary office chair comfortable and healthy experience design are summarized. Secondly, based on the product structure and human-computer interaction design, the internal demand of consumers is transformed into the actual demand of products, and the QFD house of quality model is output to obtain the best design scheme. Finally, through design demonstration, the integrated application of emotional design and QFD method is feasible and effective, which can form a mapping relationship between product benefits and user needs, thus realizing the man-machine interaction design of multi-adaptive office chairs.