AbstractConcrete‐filled steel tubular (CFST) trusses have seen recent development and application in bridges found in mountainous regions with deep valleys, and especially in seismic zones. In this study, a hybrid CFST truss lightweight bridge was selected as the research object. This bridge is composited of CFST composite truss girders (superstructure) and CFST lattice piers (substructure). Two different finite element models (FEM) for nonlinear seismic response analysis, one is detailed model and the other is simplified model, were established. By comparing with the detailed model, the results of the shaking table test as well as the real bridge test, the simplified model was found to be accurate. Considering the CFST columns' edge strain, the most unfavorable input direction of horizontal ground motion was perpendicular to the connection line of the bearings at both ends of the main girder. Also, the simultaneous influence of vertical ground motion and horizontal ground motion needs to be taken into consideration. By increasing the intensity of input ground motion, the yielding order of CFST lattice piers and its effect on the seismic response were also discussed. Results indicated that the bridge was in the elastic stage for the designed seismic ground motion. After the CFST lattice piers reached the plastic stage, the displacement and in‐plane bending moment had larger amplification coefficients compared to the increase coefficient of the input ground motion, while had a much smaller axial force amplification coefficient. Moreover, the in‐plane bending moment had a larger amplification coefficient in high piers compared to short piers.