Per and poly-fluoroalkyl substances (PFAS) are persistent organic pollutants, adversely affecting the environment. The strong carbon-fluorine bonds of PFASs make them resistant to physical and metabolic degradation leading to bioaccumulation, which can have serious effects on human’s health, wildlife and ecosystem. The conventional analytical techniques for the quantitative determination of PFASs in environmental matrices are HPLC, GC-MS, etc. Despite their high reliability and accuracy, these laboratory-based techniques are expensive and can analyze only a limited number of samples, which impedes their broad applicability. To advance the analysis and fast screening of samples, there is a critical need to develop cost effective, sensitive, easy to handle and portable methods for field detection of PFASs. This presentation will describe rational design of an electrochemical approach to detect the PFAS below their maximum permissible limit in drinking water. The interaction of nanomaterials with selected PFAS species and their incorporation into an electrochemical sensing design will be discussed. The developed method has potential for the onsite, selective, and ultrasensitive detection of PFASs