Recent Development of Trifluoromethyl Reagents: A Review

Abstract

Organic molecules having fluorine atom are very important since it increases the lipophilicity that is essential for drug development and additionally strong carbon-fluorine (C-F) bond makes the material unique, especially for material chemistry. Instead of elemental fluorine, recently trifluoromethylated materials (CF3) have drawn considerable attention in the agrochemical and pharmaceutical industries. In the continuous development of the trifluoromethylated reagents, over the last few decades, some trifluoromethylated reagents have been well developed and the efficiency of these reagents for incorporating CF3 group on different types of substrates are also studied. In this article, all types of available trifluoromethylated reagents and their effectiveness on suitable substrates are summarized. Additionally, the methods of synthesizing trifluoromethylated substrates are discussed. Finally, the scopes of the development of new reagents after focusing on the shortcomings of the current reagents are also discussed.