Abstract
Due to the extraordinary increase in the use of fluorine in the agrochemical and pharmaceutical industries, the introduction of fluorine atoms into active new materials has been investigated intensively in last decades. CF3 and CF2 groups in organic molecules are of special importance, and with respect to the high cost impact in the agrochemical and pharmaceutical industries, the selection of applicable synthetic routes is driven by economic aspects. In addition, the availability of CF3 and CF2 groups is restricted by chemistry and by the availability of fluorine-containing starting materials in bulk quantities. This review describes different access routes to obtain CF3 and CF2 groups in active ingredients.
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