It is difficult to quantify and certify the greenhouse gas (GHG) emission reduction in the entire process of a project of carbon capture, utilization and storage (CCUS)-enhanced oil recovery (EOR). Under the methodological framework for GHG voluntary emission reduction project, the carbon emission reduction accounting method for CCUS-EOR project was established after examining the accounting boundaries in process links, the baseline emission and project emission accounting methods, and the emission and leakage quantification and prediction models, in order to provide a certification basis for the quantification of GHG emission reduction in the CCUS-EOR project. Based on the data of energy consumption, emission and leakage monitoring of the CCUS-EOR industrial demonstration project in Jilin Oilfield, the net emission reduction efficiency is determined to be about 91.1% at the current storage efficiency of 80%. The accounting and prediction of carbon emission reduction for CCUS-EOR projects with different concentrations and scales indicate that within the project accounting boundary, the certified net emission reduction efficiency of the low-concentration gas source CCUS-EOR projects represented by coal-fired power plants is about 37.1%, and the certified net emission reduction efficiency of the high-concentration gas source CCUS-EOR projects represented by natural gas hydrogen production is about 88.9%. The proposed method is applicable to the carbon emission reduction accounting for CCUS-EOR projects under multiple baseline scenarios during the certification period, which can provide decision-making basis for the planning and deployment of CCUS-EOR projects.