Central Event Research Articles

Imaging Findings in Children Presenting with CNS Nelarabine Toxicity.

Nelarabine is a nucleoside analog critical for the treatment of patients with T-cell acute lymphoblastic leukemia/lymphoma. However, clinical peripheral and central neurologic adverse events associated with nelarabine administration have been reported. Neuroimaging of brain neurotoxicity has only been described in very few reports in pediatric patients so far. Six children with diagnosed T-cell acute lymphoblastic leukemia who clinically experienced possible, probable, or definite nelarabine-induced toxicity and underwent spine and/or brain MR imaging were reviewed. Neuroimaging findings showed a mixture of patterns including features of acute toxic leukoencephalopathy (seen in 6 cases), posterior reversible encephalopathy syndrome (2 cases), involvement of deep gray structures (1 case) and brainstem (2 cases), cranial and spinal neuropathy (2 cases each), and myelopathy (2 cases). Even though neuroimaging findings are nonspecific, the goal of this article was to alert the pediatric neuroradiologists, radiologists, and clinicians about the possibility of nelarabine-induced neurotoxicity and its broad neuroimaging spectrum.

Modelled realistic daily variation in low winter sea-ice concentration over the Barents Sea amplifies Asian cold events

The boreal wintertime atmospheric responses, especially cold events over central Asia, to low sea-ice concentration (SIC) with and without realistic daily variation over the Barents Sea are explored with the Community Atmosphere Model version 4.0 (CAM4.0). The results show that the general atmospheric responses to approximately equal winter-mean Arctic sea-ice loss with a similar pattern but with climatological versus realistic daily variation are different. With the forcing of low SIC with climatological daily variation, Asian cold events become a little longer and stronger than in the control experiment; this mainly results from the enhancement of a 500-hPa Ural anticyclonic anomaly. However, the low SIC forcing that includes realistic daily variability greatly intensifies central Asian cold events and the cyclonic anomaly downstream of the Ural anticyclone. Further analysis reveals that Asian cold events are closely associated with Arctic deep warming at an intraseasonal time scale, which is also the strongest in the perturbed experiment forced by low SIC with realistic daily variation. This work provides a better understanding of the linkage between sea-ice variation over the Barents Sea and central Asian cold events, which may improve extreme weather prediction. It also implies that it is necessary to force air–sea coupling models and atmospheric models with realistic daily SIC in the study of the relationship between Arctic sea ice and mid-latitude cold events.

Evaluating Hydrologic Sensitivity in CMIP6 Models: Anthropogenic Forcing versus ENSO

Abstract Large uncertainty exists in hydrologic sensitivity (HS), the global-mean precipitation increase per degree of warming, across global climate model (GCM) ensembles. Meanwhile, the global circulation and hence global precipitation are sensitive to variations of surface temperature under internal variability. El Niño–Southern Oscillation (ENSO) is the most dominant mode of global temperature variability and hence of precipitation variability. Here we show in phase 6 of the Coupled Model Intercomparison Project (CMIP6) that the strength of HS under ENSO is predictive of HS in the climate change context (r = 0.56). This correlation increases to 0.62 when only central Pacific ENSO events are considered, suggesting that they are a better proxy for HS under future warming than east Pacific ENSO events. GCMs with greater HS are associated with greater weakening of the Walker circulation and expansion of the Hadley circulation under ENSO. Observations of HS under ENSO suggest that it is significantly underestimated by the GCMs, with the lower bound of observational uncertainty almost double even the highest-HS GCMs. The ENSO-related transformation of the tropical circulation holds clues into how the GCMs may be improved in order to more reliably simulate future hydrological cycle intensification.

Both ANT and ATPase are essential for mitochondrial permeability transition but not depolarization

An increase in permeability of the mitochondrial inner membrane, mitochondrial permeability transition (PT), is the central event responsible for cell death and tissue damage in conditions such as stroke and heart attack. PT is caused by the cyclosporin A (CSA)-dependent calcium-induced pore, the permeability transition pore (PTP). The molecular details of PTP are incompletely understood. We utilized holographic and fluorescent microscopy to assess the contribution of ATP synthase and adenine nucleotide translocator (ANT) toward PTP. In cells lacking either ATP synthase or ANT, we observed CSA-sensitive membrane depolarization, but not high-conductance PTP. In wild-type cells, calcium-induced CSA-sensitive depolarization preceded opening of PTP, which occurred only after nearly complete mitochondrial membrane depolarization. We propose that both ATP synthase and ANT are required for high-conductance PTP but not depolarization, which presumably occurs through activation of the low-conductance PT, which has a molecular nature that is different from both complexes.

Trans-Endothelial Migration of Memory T Cells Is Impaired in Alemtuzumab-Treated Multiple Sclerosis Patients.

The breakdown of the blood-brain barrier (BBB) and the trans-endothelial migration of lymphocytes are central events in the development of multiple sclerosis (MS). Autoreactive T cells are major players in MS pathogenesis, which are rapidly depleted following alemtuzumab treatment. This modulation, in turn, inhibits CNS inflammation, but alemtuzumab's effect on T cell migration into the CNS has been less studied. Human brain endothelial cells were stimulated with pro-inflammatory cytokines to mimic an inflamed BBB in vitro. Peripheral blood mononuclear cells from healthy controls, untreated or alemtuzumab-treated patients with relapsing-remitting MS (RRMS) were added to the BBB model to assess their transmigratory capacity. Here, the migration of CD4+ effector memory T (TEM) and CD8+ central memory T (TCM) cells across the BBB was impaired in alemtuzumab-treated patients. Naïve T (Tnaïve) cells were unable to migrate across all groups. CD38 was lowly expressed on CD8+ TCM cells, particularly for RRMS patients, compared to CD8+ Tnaïve cells. CD62L expression was lower on CD4+ TEM cells than CD4+ Tnaïve cells and decreased further in alemtuzumab-treated patients. These data suggest that repopulated memory T cells are phenotypically different from naïve T cells, which may affect their transmigration across the BBB in vitro.

The Loss of a Service Dog Through Death: Experiences of Partners

The purpose of this research was to explore how service dog partners experience the death of their service dog. Twenty-five partners who had lost a service dog self-selected from those who participated in a larger quantitative study. The quantitative study consisted of an online, anonymous survey targeting service dog handlers who had lost a dog within the last five years. Directed content analysis was used to identify prevalent themes. Results demonstrate that while the death of their service dog was a central life event, their grief was often disenfranchised. Many struggled with both the need to quickly acquire another service dog and the subsequent impact this had on their ability to grieve. Given the unique relationship between service dog and handler, it is important that counselors, service dog organizations and veterinarians are aware of the challenges associated with both loss and replacement and offer appropriate support to their clients.

Clinical application of prion-like seeding in α-synucleinopathies: Early and non-invasive diagnosis and therapeutic development.

The accumulation and deposition of misfolded α-synuclein (α-Syn) aggregates in the brain is the central event in the pathogenesis of α-synucleinopathies, including Parkinson’s disease, dementia with Lewy bodies, and multiple-system atrophy. Currently, the diagnosis of these diseases mainly relies on the recognition of advanced clinical manifestations. Differential diagnosis among the various α-synucleinopathies subtypes remains challenging. Misfolded α-Syn can template its native counterpart into the same misfolded one within or between cells, behaving as a prion-like seeding. Protein-misfolding cyclic amplification and real-time quaking-induced conversion are ultrasensitive protein amplification assays initially used for the detection of prion diseases. Both assays showed high sensitivity and specificity in detection of α-synucleinopathies even in the pre-clinical stage recently. Herein, we collectively reviewed the prion-like properties of α-Syn and critically assessed the detection techniques of α-Syn-seeding activity. The progress of test tissues, which tend to be less invasive, is presented, particularly nasal swab, which is now widely known owing to the global fight against coronavirus disease 2019. We highlight the clinical application of α-Syn seeding in early and non-invasive diagnosis. Moreover, some promising therapeutic perspectives and clinical trials targeting α-Syn-seeding mechanisms are presented.

Inhibition of Alzheimer's Aβ1-42 Fibrillogenesis and Removal of Copper Ions by Polypeptides Modified Gold Nanoparticles.

Aggregation and fibrillation of β-amyloid peptides (Aβ) as well as accumulation of toxic metal ions have been believed to be the central events to cause Alzheimer's disease (AD). Thus, an attractive therapeutic tactic for AD is to design and synthesize inhibitors and metal chelators to prevent Aβ aggregation and chelate toxic metal ions. In this study, the polypeptide functionalized gold nanoparticles (PFGNP) were obtained by modifying polypeptides Cys-Gly-Gly-Gly-Leu-Pro-Phe-Phe-Asp (CGGGLPFFD) and Cys-Gly-Gly-Gly-Gly-Gly-His (CGGGGGH) onto gold nanoparticles through gold-sulfur bond. The inhibitory properties of PFGNP toward Aβ1-42 fibril formation was assessed by thioflavin T (ThT) fluorescence method and corroborated by atomic force microscopy analysis. The ability of PFGNP to complex copper ions was studied by electrochemical method. The experimental results reveal that PFGNP can effectively chelate copper ions and significantly inhibit the fibrillation of Aβ1-42 . Moreover, PFGNP exhibits significantly protective effect on Aβ-induced cytotoxicity toward human neuroblastoma SH-SY5Y cells.

The Eyewitness War Museum in the Netherlands: Spectacle, Experience, and Usurping the Witness

ABSTRACT Since 2013, the Eyewitness War Museum (EWM) in Beek, the Netherlands, has been claiming to offer a ‘lifelike’ depiction of many of the central events of the years 1940 to 1945. While incorporating some video, soundtracks, and touchscreens, the heart of the museum is its thirteen largescale multifigure dioramas filled with war memorabilia, including uniforms, weapons, and everyday artifacts. Through the lifelike mannequins and the historical objects, the visitor is invited to ‘encounter’ and experience the events of the Second World War; so much so, that the visit promises to transform them into ‘eyewitnesses.’ In distinct contrast to numerous war and Holocaust museums that aim to involve the visitor as a ‘secondary witness’ through embodiment and self-reflection, the EWM visitor ‘experiences’ history as a captivating and consumable visual display, watching from a distanced position of spectatorship. Moreover, the ‘guide’ to the museum, an ‘ordinary’ German soldier, is fictional, while the items that surround him are authentic. After two decades of valorizing witnesses and the use of survivor testimony, museums like the EWM negate and downplay their value, labeling the commodified experience of the visitor equivalent to that of an historical ‘eyewitness.’ While exploring these issues, this article also provides a new tool in analyzing visitor responses by looking not at predetermined surveys—often designed by the very people who run the museums—but rather at more casual visitor responses in guidebooks and travel sites. Reviews on TripAdvisor and the travel platform izi.TRAVEL are explored to reveal the way that visitors perceive, remember, and interpret their experience in the museum.

Expression of Long Non-Coding RNAs in Activated Human Retinal Vascular Endothelial Cells

ABSTRACT Purpose Retinal endothelial cell activation is a central event in non-infectious posterior uveitis. There is recent interest in long non-coding (lnc)RNA-targeted therapeutics for retinal diseases. We aimed to identify human retinal endothelial cell lncRNAs that might be involved in activation. Methods Eleven candidate lncRNAs were identified: GAS5, KCNQ1OT1, LINC00294, MALAT1, MEG3, MIR155HG, NEAT1, NORAD, OIP5-AS1, SENCR, TUG1. Expression was assessed by RT-PCR in human retinal endothelial cells, at baseline and following activation with interleukin (IL)-1β and tumor necrosis factor (TNF)-α. Results IL-1β significantly upregulated MEG3 and SENCR at 4 and 24 hours; LINC00294, NORAD, OIP5-AS1 and TUG1 at 24 hours; and MIR155HG at 4, 24 and 48 hours; but downregulated GAS5 at 24 and 48 hours. TNF-α significantly upregulated KCNQ1OT1, LINC00294, MEG3, NORAD and SENCR at 4 hours; SENCR and TUG1 at 24 hours; and MIR155HG at all time points. Conclusions Future studies involving manipulation of MIR155HG may be warranted to explore potential therapeutic applications for non-infectious posterior uveitis.

Effects of variable equations of state on the stability of nonlinear electrodynamics thin-shell wormholes

This paper explores the role of nonlinear electrodynamics on the stable configuration of thin-shell wormholes formulated from two equivalent geometries of Reissner–Nordström black hole with nonlinear electrodynamics. For this purpose, we use cut and paste approach to eliminate the central singularity and event horizons of the black hole geometry. Then, we explore the stability of the developed model by considering different types of matter distribution located at thin-shell, i.e. barotropic model and variable equations of state (phantomlike variable and Chaplygin variable models). We use linearized radial perturbation to explore the stable characteristics of thin-shell wormholes. It is interesting to mention that Schwarzschild and Reissner–Nordström black holes show the unstable configuration for such type of matter distribution while Reissner–Nordström black hole with nonlinear electrodynamics expresses stable regions. It is found that the presence of nonlinear electrodynamics gives the possibility of a stable structure for barotropic as well as variable models. It is concluded that stable region increases for these models by considering higher negative values of coupling constant [Formula: see text] and the real constant [Formula: see text].

МОТИВ ПАМЯТИ И ЕГО ТРАНСФОРМАЦИЯ В ЛИТЕРАТУРЕ СОВЕТСКОЙ И ПОСТСОВЕТСКОЙ ДЕЙСТВИТЕЛЬНОСТИ

Statement of the problem. The predominant appeal of modern writers to the experience of the past leads to a shift in the temporal regime, and the transformation of the discourse of cultural memory has a wide range of author’s strategies. The realization of the motif of memory as evidence or reconstruction is reflected in the structure of texts at the level of chronotope, composition, and genre. The purpose of the study is to analyze the ways of transforming the motif of memory on the example of the works of Soviet and post-Soviet literature: M. Bulgakov “The White Guard”, B. Pasternak “Doctor Zhivago”, and E. Vodolazkin “The Aviator”. Research methods are cultural-historical, comparative-typological, motif, narratological, and structural-semiotic analysis of the text. Research results. The moment of a historical turning point as a central event actualizes the emergence of a cultural and historical chronotope, which at the same time is opposed to the chronotope of the house. At the metaphorical level, the traditional mythologems used in the image of a house, city, nature are in constant interaction with the cultural myth, which is reflected in the literary allusion. The conflict of the asymmetry of memory gives way to the conflict between the “remembering man” and oblivion. Conclusions: The literature of the post-Soviet period is at a sufficient distance to work through the traumatic experience; however, it is forced to reconstruct the past on the basis of the evidence that has already been left – to be a “witness of witnesses”. Overcoming the trauma of memory is the leading theme of modern literature.

Central apnea detection in premature infants using machine learning

Background and objectiveApnea of prematurity is one of the most common diagnosis in neonatal intensive care units. Apneas can be classified as central, obstructive or mixed. According to the current international standards, minimal fluctuations or absence of fluctuations in the chest impedance (CI) suggest a central apnea (CA). However, automatic detection of reduced CI fluctuations leads to a high number of central apnea-suspected events (CASEs), the majority being false alarms. We aim to improve automatic detection of CAs by using machine learning to optimize detection of CAs among CASEs. MethodsUsing an optimized algorithm for automated detection, all CASEs were detected in a population of 10 premature infants developing late-onset sepsis and 10 age-matched control patients. CASEs were inspected by two clinical experts and annotated as CAs or rejections in two rounds of annotations. A total of 47 features were extracted from the ECG, CI and oxygen saturation signals considering four 30 s-long moving windows, from 30 s before to 15 s after the onset of each CASE, using a moving step size of 5 s. Consecutively, new CA detection models were developed based on logistic regression with elastic net penalty, random forest and support vector machines. Performance was evaluated using both leave-one-patient-out and 10-fold cross-validation considering the mean area under the receiver-operating-characteristic curve (AUROC). ResultsThe CA detection model based on logistic regression with elastic net penalty returned the highest mean AUROC when features extracted from all four time windows were included, both using leave-one-patient-out and 10-fold cross-validation (mean AUROC of 0.88 and 0.90, respectively). Feature relevance was found to be the highest for features derived from the CI. A threshold for the false positive rate in the mean receiver-operating-characteristic curve equal to 0.3 led to a high percentage of correct detections for all CAs (78.2%) and even higher for CAs followed by a bradycardia (93.4%) and CAs followed by both a bradycardia and a desaturation (95.2%), which are more critical for the well-being of premature infants. ConclusionsModels based on machine learning can lead to improved CA detection with fewer false alarms.

Modelling the flare in NGC 1097 from 1991 to 2004 as a tidal disruption event

ABSTRACT In the letter, interesting evidence is reported to support a central tidal disruption event (TDE) in the known AGN NGC 1097. Considering the motivations of TDE as one probable origination of emission materials of double-peaked broad emission lines and also as one probable explanation to changing-look AGN, it is interesting to check whether there are clues to support a TDE in NGC 1097, not only a changing-look AGN but also an AGN with double-peaked broad emission lines. Under the assumption that the onset of broad Hα emission was due to a TDE, the 13 yr-long (1991–2004) variability of double-peaked broad Hα line flux in NGC 1097 can be well predicted by theoretical TDE model, with a (1 − 1.5) M⊙ main-sequence star tidally disrupted by the central BH with TDE model determined mass about (5 − 8) × 107 M⊙. The results provide interesting evidence to not only support TDE-related origin of double-peaked broad line emission materials but also support TDE as an accepted physical explanation to physical properties of changing-look AGN.

Association between retinal vein occlusion and early-stage hypertension: A propensity score analysis using a large claims database.

The threshold of hypertension was lowered from systolic blood pressure (SBP)/diastolic blood pressure (DBP) 140/90 mmHg to 130/80 mmHg by the 2017 American College of Cardiology/American Heart Association blood pressure (BP) guideline. Thus, we investigated the association between retinal vein occlusion (RVO) occurrence and early-stage hypertension. This retrospective cohort study used the JMDC Claims Database (JMDC Inc., Tokyo, Japan) between 2005 and 2020. Individuals undergoing health checkups who had data on BP and did not take antihypertensive medications were included. They were classified into four BP groups: normal BP (SBP < 120 mmHg and DBP < 80 mmHg), elevated BP (SBP 120-129 mmHg and DBP < 80 mmHg), stage 1 hypertension (SBP 130-139 mmHg or DBP 80-89 mmHg), and stage 2 hypertension (SBP ≥ 140 mmHg or DBP ≥ 90 mmHg). Date of RVO occurrence was defined as the first date of diagnosis. We estimated adjusted hazard ratios for RVO and central RVO using weighted Cox regression to adjust for potential confounders. A total of 2,703,264 individuals were eligible. During a mean follow-up of 1,091 days, 3,526 RVO and 828 central RVO events occurred. The adjusted hazard ratios (95% confidence intervals) were 1.37 (1.19-1.57), 1.95 (1.75-2.18), and 3.33 (2.95-3.76) for RVO and 1.44 (1.07-1.93), 2.17 (1.72-2.73), and 3.76 (2.91-4.86) for central RVO in the elevated BP, stage 1 hypertension, and stage 2 hypertension groups, respectively, compared with the normal BP group. Even individuals with early-stage hypertension showed higher risks for RVO and central RVO than individuals with normal BP.

A central arctic extreme aerosol event triggered by a warm air-mass intrusion

Frequency and intensity of warm and moist air-mass intrusions into the Arctic have increased over the past decades and have been related to sea ice melt. During our year-long expedition in the remote central Arctic Ocean, a record-breaking increase in temperature, moisture and downwelling-longwave radiation was observed in mid-April 2020, during an air-mass intrusion carrying air pollutants from northern Eurasia. The two-day intrusion, caused drastic changes in the aerosol size distribution, chemical composition and particle hygroscopicity. Here we show how the intrusion transformed the Arctic from a remote low-particle environment to an area comparable to a central-European urban setting. Additionally, the intrusion resulted in an explosive increase in cloud condensation nuclei, which can have direct effects on Arctic clouds’ radiation, their precipitation patterns, and their lifetime. Thus, unless prompt actions to significantly reduce emissions in the source regions are taken, such intrusion events are expected to continue to affect the Arctic climate.

The role of LRP1 in Aβ efflux transport across the blood-brain barrier and cognitive dysfunction in diabetes mellitus

BackgroundThe incidence of cognitive dysfunction in diabetes is increasing yearly, which severely affects the quality of life of patients and places a heavy burden on families and society. It has been demonstrated that impaired clearance of cerebral amyloid β-protein (Aβ) is a central event in the initiation and progression of Aβ deposition and cognitive impairment in diabetic patients. However, until now, the molecular mechanism by which diabetes mellitus induces impaired clearance of Aβ has remained unclear. ObjectiveTo investigate the role and mechanism of lipoprotein receptor-related protein 1 (LRP1) in Aβ clearance impairment and cognitive function damage caused by diabetes. MethodsSPF male C57BL/6 mice were bred, and streptozotocin (STZ) (60 mg/kg/d) was intraperitoneally injected for 5 days to establish a diabetes model. The novel object recognition test and fear conditioning test were used to assess the cognitive function of mice in each group. Western blotting, qRT-PCR, ELISAs, and immunofluorescence staining were used to detect the expression levels of Aβ and Aβ clearance-related proteins in mouse brains. HBMECs were cultured in vitro to establish the blood-brain barrier model. The clearance rate of Aβ and the expression levels of LRP1 were measured under different glucose concentration culture conditions. HBMECs were transfected with lentivirus to overexpress or knock down the LRP1, and then, the changes in Aβ clearance were detected again. We injected adeno-associated virus AAV9-SP-A-LRP1 shRNA into the tail vein of DM mice to selectively knock down LRP1 gene expression in cerebral vascular endothelial cells. Then, the cognitive function and the expression levels of Aβ and Aβ clearance-related proteins in the brains of normal, DM and LRP1 knockdown mice were detected. ResultsCompared with the controls, diabetic mice showed impaired cognitive performance, increased deposition of Aβ in the brain and decreased expression of LRP1 in the brain microvasculature. In vitro experiments showed that high glucose can downregulate the expression of LRP1 in HBMECs and damage the Aβ clearance across the blood-brain barrier (BBB). The reduction in the clearance rate of Aβ induced by high glucose was reversed by LRP1 overexpression but further substantially decreased when LRP1 was knocked down. ConclusionHyperglycemia can impair Aβ efflux in the brain by downregulating the expression of LRP1 in the brain microvasculature, eventually resulting in cognitive impairment.

Recent weakening of the relationship between El Niño–Southern Oscillation and western North Pacific tropical cyclone season onset date

AbstractThis study investigates the climate drivers of western North Pacific (WNP) tropical cyclone season onset date (TCSOD). We find that the interannual relationship between WNP TCSOD and El Niño–Southern Oscillation (ENSO) varies considerably on interdecadal time scales. The association between TCSOD and ENSO, as measured by the Niño3.4 index, is significant during the first subperiod from 1979 to 1998 (r = .51) but becomes insignificant (r = .01) during the second subperiod from 1999 to 2019. This relationship degradation is mainly due to shifting ENSO conditions with more frequent occurrences of tropical central Pacific ENSO events since the late 1990s. Tropical eastern Pacific ENSO events cause changes in the low‐level large‐scale circulation over the tropical western WNP, where early season WNP TC genesis typically occurs, via a Gill‐type Rossby wave response. Tropical central Pacific ENSO events have a limited impact over this region. These relationships are confirmed by a stable and strong association between tropical eastern Pacific ENSO and TCSOD for the whole period (r = .63) and for the two subperiods (r = .72/r = .56), while the correlation between central Pacific ENSO events and TCSOD is weak for the whole period (r = −.01) and for the two subperiods (r = −.03/r = −.13). We further find that the Pacific meridional mode is a robust indicator of TCSOD over the WNP regardless of shifting ENSO conditions. Results of this study may provide useful information for decadal climate prediction of WNP TCSOD.

로맨스 웹소설 속 가상 역사의 구현 방식 연구

This paper discussed the realization of virtual history in romance web novels, focusing on &lt;Midnight Mirage&gt;. &lt;Midnight Mirage&gt; depicted the love story with King Munjong and Queen Hyeondeok as motifs. &lt;Midnight Mirage&gt; used the story of Tumun-dong 72 Loyalists and the achievements of various national institutions in King Sejong to create various central event. The fictional elements of the story were used to form a inter-class romance, emphasize the personal feelings of the opposing forces and highlight the power of the crown prince. The characteristics of a virtual history are as follows. First, it was actively borrowing modern cultural customs. Second, it takes the form of a short episode when a historical figure appears. These characteristics have epic effects such as inducing rapid immersion of readers and relaxing the tension of the narrative.

The Role of Protein Arginine Methyltransferases in DNA Damage Response.

In response to DNA damage, cells have developed a sophisticated signaling pathway, consisting of DNA damage sensors, transducers, and effectors, to ensure efficient and proper repair of damaged DNA. During this process, posttranslational modifications (PTMs) are central events that modulate the recruitment, dissociation, and activation of DNA repair proteins at damage sites. Emerging evidence reveals that protein arginine methylation is one of the common PTMs and plays critical roles in DNA damage response. Protein arginine methyltransferases (PRMTs) either directly methylate DNA repair proteins or deposit methylation marks on histones to regulate their transcription, RNA splicing, protein stability, interaction with partners, enzymatic activities, and localization. In this review, we summarize the substrates and roles of each PRMTs in DNA damage response and discuss the synergistic anticancer effects of PRMTs and DNA damage pathway inhibitors, providing insight into the significance of arginine methylation in the maintenance of genome integrity and cancer therapies.