Central Administration Research Articles

College Student Preferences for Campus Mental Health Services and Practices

ABSTRACT The decline in college student mental health has been articulated by counseling center directors and administrators in higher education and has been thoroughly documented by research. Counseling centers have responded with diverse functions and services to holistically address the emotional and behavioral health needs of students. Beyond clinical services, counseling centers have developed services involving comprehensive prevention/outreach, case management, consultation, and collaboration. The question remains: how do students view the importance of such services and functions? The present study addresses this question as follow-up to past research and data that have illuminated the comprehensive nature of campus counseling center services. Findings in this study indicate that students who used campus counseling services, as well as students-in-general, agreed with the importance of the full range of comprehensive counseling center services. Specific responses to service preferences were also investigated (e.g., 24–7 Helpline, counseling services should be free to students).

Raphe glucose-sensing serotonergic neurons stimulate KNDy neurons to enhance LH pulses via 5HT2CR: rat and goat studies

Dysfunction of central serotonergic neurons is known to cause depressive disorders in humans, who often show reproductive and/or glucose metabolism disorders. This study examined whether dorsal raphe (DR) serotonergic neurons sense high glucose availability to upregulate reproductive function via activating hypothalamic arcuate (ARC) kisspeptin neurons (= KNDy neurons), a dominant stimulator of gonadotropin-releasing hormone (GnRH)/gonadotropin pulses, using female rats and goats. RNA-seq and histological analysis revealed that stimulatory serotonin-2C receptor (5HT2CR) was mainly expressed in the KNDy neurons in female rats. The serotonergic reuptake inhibitor administration into the mediobasal hypothalamus (MBH), including the ARC, significantly blocked glucoprivic suppression of luteinizing hormone (LH) pulses and hyperglycemia induced by intravenous 2-deoxy-D-glucose (2DG) administration in female rats. A local infusion of glucose into the DR significantly increased in vivo serotonin release in the MBH and partly restored LH pulses and hyperglycemia in the 2DG-treated female rats. Furthermore, central administration of serotonin or a 5HT2CR agonist immediately evoked GnRH pulse generator activity, and central 5HT2CR antagonism blocked the serotonin-induced facilitation of GnRH pulse generator activity in ovariectomized goats. These results suggest that DR serotonergic neurons sense high glucose availability to reduce gluconeogenesis and upregulate reproductive function by activating GnRH/LH pulse generator activity in mammals.

Impact of Peripheral Versus Central Insulin on Cerebrovascular Compliance in Healthy Young Adults

Objective: Vascular compliance is an essential component of cerebral blood flow regulation. Prior work has shown cerebral vasodilation (elicited by hypercapnia) reduces cerebrovascular compliance (Ci); however, this work has yet to be translated to other vasoactive compounds. Insulin has important vasodilatory effects in the peripheral circulation, but less is known about the role of insulin in cerebrovascular control. Herein, we hypothesized both peripheral (intravenous) and central (intranasal) insulin administration would increase indices of cerebral blood flow and reduce Ci in healthy young adults. Methods: Twenty-five healthy young adults (8 female; 26±7 yrs, 25±3 kg/m2) were assigned to two separate protocols (NCT05244694, NCT05153395). Middle cerebral artery blood velocity (MCAv, transcranial Doppler ultrasound) was measured at baseline and under two study conditions: 1) at the end of a 60 min hyperinsulinemic euglycemic infusion, and 2) 60 min following 160 IU of intranasal insulin. Indices of Ci were calculated using a modified Windkessel model applied to blood pressure (finger photoplethysmography) and corresponding MCAv waveforms collected over a 5-min period (10 waveforms) at baseline and during the aforementioned insulin conditions. Results: Blood glucose remained unchanged throughout both protocols (both p>0.05). MCAv was maintained over time under both insulin conditions (protocol 1: 60±13 to 62±17 cm/s, p=0.635; protocol 2: 58±9 to 53±14 cm/s, p=0.146). In contrast, Ci decreased (0.00028±0.00010 to 0.00021±0.00007 cm/s/mmHg, p=0.010) from baseline during peripheral (intravenous) insulin administration. No change in Ci (0.00049±0.00025 to 0.00040±0.00018 cm/s/mmHg, p=0.189) were observed following intranasal insulin administration. Conclusions: Contrary to our hypothesis, there was no effect of peripheral or central insulin administration on resting MCAv in healthy young adults. However, intravenous (but not intranasal) insulin reduced Ci by approximately 25% from baseline values. These findings advance our understanding of cerebrovascular control mechanisms during insulin exposure and provide the opportunity to extend this work to diseased states characterized by insulin resistance, including diabetes. CAFNR Joy of Discovery (JKL, JP). This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Cell-autonomous Action of the FGF19 Promotes UCP1 Expression and Function in Human Brown Adipocytes

Fibroblast growth factor 19 (FGF19) is an intestine-derived hormone that regulates glucose and energy metabolism. Central and systemic administration of human FGF19 in mice promotes increased energy expenditure and body weight loss through mechanisms that are not fully understood. In this study, we investigated whether FGF19 can activate thermogenesis in brown adipocytes (BA) in a cell-autonomous manner. We differentiated immortalized human brown preadipocytes into mature adipocytes with adipogenic induction media in the presence and absence of FGF19 for 18 days to evaluate the effects of FGF19 on adipogenesis and thermogenesis. Through qPCR and RNA-sequencing analyses, we observed that FGF19 receptors were expressed in both brown preadipocytes and mature BA. However, the obligatory FGF19 co-receptor, β-klotho, was not expressed in preadipocytes, suggesting that the effects of FGF19 must occur preferentially in mature BA. Lipid staining with Oil Red O as well as gene expression of the adipogenic markers fatty acid binding protein (FABP4) and peroxisome proliferator activated receptor-γ (PPAR-γ) showed that adipogenesis was not affected by FGF19. We then treated mature BA with FGF19 (100 ng/mL) acutely and chronically to evaluate FGF19-induced changes in signaling, gene transcription, and thermogenic function. FGF19 signaling was assessed by measuring ERK1/2 phosphorylation levels, which increased within 5 min and remained elevated for at least 30 min after treatment. Using Seahorse assays, we observed that 24-hour FGF19 treatment promoted increased basal respiration, ATP production, and proton leak in human BA, indictive of enhanced mitochondrial function. Since proton leak across the inner membrane through the uncoupling protein 1 (UCP1) generates heat, we assessed the expression of UCP1 and other thermogenic genes. Interestingly, FGF19 treatment specifically increased UCP1 gene expression without affecting other classical adrenergic-mediated thermogenic genes, such as deiodinase 2 (DIO2), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1-α), PR domain containing 16 (PRDM16), and cell death-inducing DNA fragmentation factor A (CIDEA). These findings suggest that FGF19 regulates UCP1 expression through non-canonical pathways. Future work will elucidate the mechanism by which FGF19 promotes UCP1 gene expression in mature BA. Taken together, FGF19 stimulates ERK1/2 phosphorylation and UCP1 expression in human BA, leading to enhanced mitochondrial respiration. These results provide new mechanistic insights into FGF19’s effects on metabolic regulation. Topic subcategories: Adipocyte biology. Funding sources: Sao Paulo Research Foundation (FAPESP): 2022/15148-2 and NIH R01 DK102898. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Chronic central leptin administration attenuates kidney dysfunction and injury in a model of ischemia/reperfusion-induced acute kidney injury

Kidney disease occurs in approximately 15% of the adult population, accounting for 37 million people in the US alone. Lack of blood flow is a major driver of kidney injury and no therapeutic modalities have shown substantial effcacy in treating ischemia-induced acute kidney injury (AKI). We recently demonstrated that activation of the brain leptin-melanocortin system dramatically improves cardiomyocyte mitochondrial function, energy metabolism and contractility, preserving cardiac function and preventing progression of heart failure following myocardial infarction and ischemia/reperfusion injury. In the present study we examined whether chronic intracerebroventricular (ICV) leptin administration protects the kidney against ischemia/reperfusion (I/R)-induced AKI. Twelve-week old male rats were implanted with an ICV cannula into the right lateral ventricle and 8-10 days after surgery, leptin (0.021 mg/hr, n=8) or saline vehicle (0.5 ml/h, n=8) was infused via osmotic minipump connected to the ICV cannula for 12 days. On day 8 of leptin or vehicle infusion, rats were submitted to unilateral ischemia/reperfusion (UIR) by clamping the left pedicle for 30 min. To control for leptin-induced reductions in food intake, the vehicle group was pair-fed (UIR-PF) to match the same amount of food consumed by leptin-treated (UIR-Leptin) rats. On the 12th day of leptin or vehicle infusion (i.e. 4th day after AKI), single-left kidney glomerular filtration rate (GFR) was measured, blood samples were collected to quantify white blood cells, and kidneys were collected for histological assessment of injury. Chronic leptin infusion reduced body weight by 20±1% compared to only 10±1% reduction in UIR-PF. UIR-Leptin rats also showed reduced right and left kidney weights (right: 1040±24 vs. 1281±36 and left: 1127±71 vs. 1707±45 mg, for UIR-Leptin and UIR-PF, respectively). Leptin infusion improved GFR (0.50±0.06 vs. 0.13±0.03 ml/min/g KW) and reduced kidney injury scores. Leptin treatment also increased circulating white blood cells count compared to UIR-PF rats (16.3±1.3 vs. 9.8±0.6 k/mL). Thus, leptin, via its actions on the central nervous system, confers significant protection against major kidney dysfunction and damage in a model of ischemia/reperfusion-induced AKI. NIH grants: (1R0DK1121411 (do Carmo), 1R0HL1630376 (da Silva/do Carmo), P20GM104357 (Hall), P30GM149404 (Hall) and U54GM115428 (Hall)). This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

An ontology-based knowledge representation using OWL for Indonesian local regulations

<div class="WordSection1"><p>Inconsistencies in legislation can significantly hinder the effectiveness and efficiency of the central and local government administrations. The Indonesian government requires standard harmonization of each piece of legislation to prevent such problems. However, this process is often manual and requires the involvement of multiple experts with varying backgrounds. This leads to high resource expenses regarding human resources, cost, and time. To address this, a software system should be developed to detect potential disharmony among legislation. However, the system requires a well-constructed legislation conceptual model represented in an appropriate modeling language. This research aims to develop the Indonesian local regulation ontology in web ontology language (OWL), where no such ontology exists. The ontology was created using the Ontology Development 101 methodology and evaluated using competency questions and expert judgment approaches. The resulting ontology becomes a basis for developing an automatic recommendation system to detect potentially inconsistent legislation in future works.</p></div>

How effective is equality regulation in reducing gender gaps in the labor market?☆

The gender gap in both employment and labour participation has narrowed markedly in recent decades in Spain. However, this decline seems to have slowed and shows a certain persistence. The solution to this problem can respond to different regulatory or non-regulatory policies. This article studies the evolution of the regulatory framework for the formulation of possible policy recommendations. We identify and quantify for the first time when, at what rate and in what regions, Spanish administrations have adopted regulations aimed at combating discrimination against women, achieving gender equality or approved measures related to the work-life balance. The study is based on a text analysis of 297,402 regulations adopted in the period 1996–2022. The indicators reveal the high degree of heterogeneity in terms of the legislation. Non-discrimination legislation was the most developed and frequent, with 11,228 regional regulations and 2590 central administration regulations adopted. We show that the volume of new regulations, mainly those related to discrimination and work-life balance, has contributed to the reduction in gender gaps. Policy actions by administrations should concentrate on these two modes of intervention. The general analysis of regulation in this area also allows for some recommendations in terms of “better regulation” policies, such as the introduction of gender equality assessments (specific regulatory impact reports).

Digital Transformation of Supreme Audit Institution (SAI) —A Mini-Review on the Case of Romanian Court of Accounts (RCA)

The present endeavor compellingly addresses the issue of the necessity and importance of IT support for the control and audit activities of the Romanian Court of Accounts (RCA), making reference to the institution's operations in the context of the digitization of central public administration and the implications for the conducted control/audit. Subsequently, we highlight the most significant strategic elements recently established regarding the digitization of the RCA' activities, as well as the potential advantages. The final part is dedicated to conclusions, the limitations of our research, and future research directions, focusing on addressing issues that have been inadequately addressed so far. The paper is intended for specialists in the field, audit professionals, the academic community, etc. In addressing the topic, we considered relevant literature, including our previous research, as well as bibliographic material provided by the RCA, indicated in the „References” section.

Methyl jasmonate ameliorates pain-induced learning and memory impairments through regulating the expression of genes involved in neuroinflammation.

Orofacial pain with high prevalence is one of the substantial human health issues. The importance of this matter became more apparent when it was revealed that orofacial pain, directly and indirectly, affects cognition performances. Currently, researchers have focused on investigating pharmaceutics to alleviate pain and ameliorate its subsequent cognitive impairments. In this study, the rats were first treated with the central administration of methyl jasmonate (MeJA), which is an antioxidant and anti-inflammatory bio-compound. After 20min, orofacial pain was induced in the rats by the injection of capsaicin in their dental pulp. Subsequently, the animals' pain behaviors were analyzed, and the effects of pain and MeJA treatments on rats learning and memory were evaluated/compared using the Morris water maze (MWM) test. In addition, the expression of tumor necrosis factor-α (TNF-α), IL-1β, BDNF, and COX-2 genes in the rats' hippocampus was evaluated using real-time polymerase chain reaction. Experiencing orofacial pain resulted in a significant decline in the rats learning and memory. However, the central administration of 20μg/rat of MeJA effectively mitigated these impairments. In the MWM, the performance of the MeJA-treated rats showed a two- to threefold improvement compared to the nontreated ones. Moreover, in the hippocampus of pain-induced rats, the expression of pro-inflammatory factors TNF-α, IL-1β, and COX-2 significantly increased, whereas the BDNF expression decreased. In contrast, MeJA downregulated the pro-inflammatory factors and upregulated the BDNF by more than 50%. These findings highlight the notable antinociceptive potential of MeJA and its ability to inhibit pain-induced learning and memory dysfunction through its anti-inflammatory effect.

Tendencias de las quejas ante el Defensor del Pueblo en Angola: análisis a partir de informes de actividad

Since the appearance of the Ombudsman in the Angolan legal system, through Article 142 of the Constitutional Law of 1992, and the election of the first Ombudsman in 2005, Angolans have had an independent administrative authority responsible for defending the fundamental rights and freedoms of citizens. The complaint to the Ombudsman represents an administrative guarantee for individuals to claim their rights and protect their legitimate interests in the face of an act or omission by the Public Administration that violates or threatens them. The aim of this article is to analyse trends in complaints to the Ombudsman, based on his activity reports for the years 2011, 2014, 2018 and 2022. This is an exploratory and documentary study, which analysed sociodemographic variables, the subject of the complaint, the institution targeted and the solution given. The interpretative or hermeneutic method was also used in the interpretation of legislative texts. The results point to an increasing number of complaints to the Ombudsman, mostly made by citizens of Luanda, with a predominance of males, with the most targeted institutions being central state administration bodies, and filing as the most recurrent solution. The conclusion is that there is an annual increase in the number of complaints, although this does not reflect the diversity of the more than thirty million inhabitants. On the other hand, the slowness of responses and the population's unfamiliarity with the role of this authority can be pointed to as reasons for the low level of adherence.

Industrial location and urban macroform prediction model based on cellular automata and multi-criteria decision-making methods (ILAUFM)

The relationships between industrialization and urban regions, as well as technological advancements, innovations, and new work patterns and organizations, significantly impact the structuring of cities. Industrial sectors can become key drivers in shaping the form and macrostructure of a city over time. By examining and evaluating the existing system of structures and relations in the settlements in order to “estimate the land use differentiations” that may arise in the future and “to determine the spatial location of industrial facilities or sites,” a model has been developed. This model aims to predict potential “land use differentiations” and determine the “spatial location selection of industrial facilities or sites” in the future based on the analysis and evaluation of existing structures and relational systems in settlements. The model consists of the integration of the LUCAM, which is based on a cellular automata operating system, along with the “GIS-Based Integrated Industrial Area Location Selection Model,” which evaluates all data under the main headings of natural structure characteristics, socio-economic structure characteristics, and built environment characteristics using weighted overlay analysis. In this article, the general structure of the model developed within the scope of the research and İnegöl sampling are explained. The outputs of this model can be used for alternative separation for logistics centers, residential areas, secondary centers, reinforcement areas, and industrial sites in different settlements. In addition, in the research, a detailed model was designed by integrating decision-makers (central administrations, local administrations, registered users, NGOs) into the urban planning process. The proposed model can be used as a tool in designing transportation and other urban systems (distribution order of equipment areas, green area system, grading of centers, etc.).

Practical Medical Image Generation with Provable Privacy Protection Based on Denoising Diffusion Probabilistic Models for High-Resolution Volumetric Images

Local differential privacy algorithms combined with deep generative models can enhance secure medical image sharing among researchers in the public domain without central administrators; however, these images were limited to the generation of low-resolution images, which are very insufficient for diagnosis by medical doctors. To enhance the performance of deep generative models so that they can generate high-resolution medical images, we propose a large-scale diffusion model that can, for the first time, unconditionally generate high-resolution (256×256×256) volumetric medical images (head magnetic resonance images). This diffusion model has 19 billion parameters, but to make it easy to train it, we temporally divided the model into 200 submodels, each of which has 95 million parameters. Moreover, on the basis of this new diffusion model, we propose another formulation of image anonymization with which the processed images can satisfy provable Gaussian local differential privacy and with which we can generate images semantically different from the original image but belonging to the same class. We believe that the formulation of this new diffusion model and the implementation of local differential privacy algorithms combined with the diffusion models can contribute to the secure sharing of practical images upstream of data processing.

Retraction Note: Dose selection of central or peripheral administration of sufentanil affect opioid induced cough?: a prospective, randomized, controlled trial

This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12871-024-02522-9.

In memoriam Prof. Dr. Dr.h.c.mult. György Jenei

Professor Dr. Dr.h.c.mult. György Jenei, the doyen of Central and Eastern European Public Administration, passed away peacefully on 4 February 2024; born in 1942, he was 82 years old. He was for many decades the leading figure of the field in our region; he personified it; he had preserved it during darker times; and he had led it again to prominence since 1989, with persistence, integrity, and style. He did so both in form and in contents – the former both at his home, Corvinus University of Budapest, and in his many leadership functions in professional and scholarly associations, including the NISPAcee Presidency during the crucial years of the Global Financial Crisis. And he truly did carry the torch of Public Administration during the times when its inefficiency was not an accident, but a core part of the local system; Professor Jenei’s early work on Max Weber was undertaken at a time when this was a politically highly incorrect thing to do.

Intestinal perfusion of unacylated ghrelin alleviated metabolically associated fatty liver disease in rats via a central glucagon-like peptide-1 pathway.

Unacylated ghrelin (UAG), the unacylated form of ghrelin, accounts for 80%-90% of its circulation. Accumulated studies have pointed out that UAG may be used to treat metabolic disorders. This study aimed to investigate the effect of intestinal perfusion of UAG on metabolically associated fatty liver disease (MAFLD) induced by a high-fat diet and its possible mechanisms. Neuronal retrograde tracking combined with immunofluorescence, central administration of a glucagon-like peptide-1 receptor (GLP-1R) antagonist, and hepatic vagotomy was performed to reveal its possible mechanism involving a central glucagon-like peptide-1 (GLP-1) pathway. The results showed that intestinal perfusion of UAG significantly reduced serum lipids, aminotransferases, and food intake in MAFLD rats. Steatosis and lipid accumulation in the liver were significantly alleviated, and lipid metabolism-related enzymes in the liver were regulated. UAG upregulated the expression of GLP-1 receptor (GLP-1R) in the paraventricular nucleus (PVN) and GLP-1 in the nucleus tractus solitarii (NTS), as well as activated GLP-1 neurons in the NTS. Furthermore, GLP-1 fibers projected from NTS to PVN were activated by the intestinal perfusion of UAG. However, hepatic vagotomy and GLP-1R antagonists delivered into PVN before intestinal perfusion of UAG partially attenuated its alleviation of MAFLD. In conclusion, intestinal perfusion of UAG showed a therapeutic effect on MAFLD, which might be related to its activation of the GLP-1 neuronal pathway from NTS to PVN. The present results provide a new strategy for the treatment of MAFLD.NEW & NOTEWORTHY Intestinal perfusion of UAG, the unacylated form of ghrelin, has shown promising potential for treating MAFLD. This study unveils a potential mechanism involving the central GLP-1 pathway, with UAG upregulating GLP-1R expression and activating GLP-1 neurons in specific brain regions. These findings propose a novel therapeutic strategy for MAFLD treatment through UAG and its modulation of the GLP-1 neuronal pathway.

New smart twisting active rotor (STAR): pretest predictions

A Mach-scaled model rotor with an active twist capability is in preparation for a wind tunnel test in the large low-speed facility of the German-Dutch wind tunnel (DNW) with international participation by the German Aerospace Center (DLR), US Army Combat Capabilities Development Command (DEVCOM) Aviation & Missile Center, National Aeronautics and Space Administration, French Aerospace Lab (ONERA), Korea Aerospace Research Institute, Konkuk University, Japan Aerospace Exploration Agency, Glasgow University, and DNW. To get the maximum benefit from the test and the most valuable data within the available test time, the tentative test matrix was covered by predictions of the partners, active twist benefits were evaluated, and support was provided to the test team to focus on the key operational conditions.

The role of the Act of 5 November 1916 in starting the process of rebuilding Polish statehood

The following text is devoted to the issues of the fate of Polish lands being decided during World War I. Above all it discusses the Act of 5 November 1916 issued by two of the partitioning powers – the Second German Reich and Austria-Hungary – and assesses its role in the future revival of Polish statehood. This legal act led to the establishing of semi-sovereign central Polish administration bodies, which prepared a draft constitution for the future state (monarchist), a draft electoral law for the Sejm, and took many steps to establish local Polish authorities, the judiciary, and the education system. The authors analyse the establishment of the two main central bodies under the auspices of Germany and Austria-Hungary (the Provisional Council of State, and the Regency Council), describe the monarchist project of the Polish constitution created thanks to the Provisional Council of State, and the electoral law designed at that time. They also question to what extent the acts of 5 November can be associated with the concept of “Mitteleuropa” – the creation of an economic and political union in Central and Eastern Europe of states that were to function under strict German control. This concept, created in the second half of the 19th century, was redefined during World War I. The historical-legal method was used in work on this article, supplemented with the dogmatic-legal and comparative methods.

The prevailing administrative patterns among the managers of the central administration and their relationship with the level of delegation of authority to them from the point of view of employees of the Erbil General Directorate of Education

The prevailing administrative patterns among the managers of the central administration and their relationship with the level of delegation of authority to them from the point of view of employees of the Erbil General Directorate of Education

In-School Suspension Through the Lens of Whiteness as Property: Exploring a School District’s Role in Maintaining Educational Inequality

Despite impacting almost three million students annually, and disproportionately impacting Black students, little is known about district policy and central office staff in the use of in-school suspension. The purpose of this study was to understand how districts use in-school suspension over time, with attention to racial disparities, programmatic changes, and central office perspectives. Case study methods were used to examine in-school suspension in one large school district in the Western United States. Data included two district board school discipline policies, quantitative in-school suspension data, and interviews with central office staff. We found a history of on-going racial disparities for Black and Latinx students and that decisions made by central office about in-school suspension had likely sustained these disparities over time. District policy goals of reducing racial disparities were found to be largely rhetorical in the face of an ethos of non-enforcement. Central office administrators believed they lacked the power to hold school principals accountable for implementing school discipline policy with fidelity to redressing racial disparities. Through the concept of Whiteness as Property, we argue these patterns demonstrated central office administrators’ protection of White educational and political propertied interests above those of educational opportunities for Black and Latinx students. This study contributes to the literature on in-school suspension by finding discrepancies between policy and practice and contributes to the field’s understanding of how school autonomy can undermine equity-oriented school discipline policies through racial negligence.

Central and Peripheral Medication Administration Practices in Pediatric Patients.

Central and Peripheral Medication Administration Practices in Pediatric Patients.