Cemento-ossifying Fibroma Research Articles

Ossifying Fibroma of Non-odontogenic Origin: A Fibro-osseous Lesion in the Craniofacial Skeleton to be (Re-)considered

In the cranio-facial skeleton, a heterogeneous group of well characterized fibro-osseous lesions can be distinguished. Whereas fibrous dysplasia can affect any skeletal bone, ossifying fibroma and cemento-osseous dysplasia exclusively develop in the cranio-facial region, with most subtypes restricted to the tooth bearing areas of the jaws. Herein we present a series of 20 fibro-osseous lesions that developed mostly in the frontal bone and in the mandible, presenting as expansile intramedullary tumors with a unique histologic appearance and an indolent clinical course. We provide evidence that these tumors are distinct from the categories included in the WHO classification and are therefore currently unclassifiable. The definition of cemento-ossifying fibroma as an odontogenic neoplasm developing only in close proximity to teeth should be re-considered and incorporate also extragnathic lesions as shown here.

RECURRENT JUVENILE PSAMMOMATOID OSSIFYING FIBROMA: A CASE REPORT

<h3>Background</h3> Juvenile psammomatoid ossifying fibroma (JPOF) is a rare, benign fibro-osseous lesion with a mean patient age of 16-33 years. JPOFs present as bony expansion, invasion, and destruction of surrounding tissue. <h3>Objective</h3> To report a case of recurrent JPOF. <h3>Case Report</h3> We present a case of recurrent JPOF. An 8-year-old girl reported to our department with the chief complaint of gradual painless swelling in the chin. The oral examination revealed a hard and nontender swelling in the anterior region of the mandible. The orthopantomogram revealed a radiolucent mass with ill-defined borders. The computed tomographic scan showed a nearly round expansile lesion, which showed multilocular radiolucency, 4.3 cm × 3.0 cm in size, and with an indefinite border. Postoperative histopathological diagnosis was reported as cemento-ossifying fibroma. Before reporting to us, the patient had been admitted to another hospital 2 years earlier with painless swelling in a similar position of the mandible. The clinical manifestations were similar to those this time. Compared with this episode, the lesion scope was small, 2.0 cm × 3.0 cm in size. The postoperative histopathologic diagnosis was reported as odontogenic myxoma at that time. <h3>Discussion</h3> Two years ago, histopathology showed a fibrocellular stroma with myxoid areas, and no calcifications were observed. In this episode, microscopic examination revealed numerous spherical ossicles resembling psammoma bodies in the cellular fibrous tissue, which are a pathognomonic histopathologic feature of JPOF. JPOFs present with aggressive local growth and high risk of recurrence. Therefore, accurate pathological diagnosis and complete surgical resection are required.

Cemento-Ossifying Fibroma of the Mandible: A Case Report Including Its Imaging and Histopathological Features

Cemento-ossifying fibroma is the uncommon benign fibro-osseous lesion of the craniofacial skeleton. The origin of this lesion has been traced to the periodontal ligament since the cells can form cement, lamellar bone, or fibrous tissue. The lesion most often occurs in the jaws, especially the mandible. Most lesions are small and incidentally found. Larger lesions cause facial asymmetry or functional impairment. The lesion is more common in females. Of the craniofacial bones, the mandible is the most commonly affected site, with the lesion typically inferior to the premolars and molars. From a radiological perspective, some lesions can be exceptionally radiopaque, or some well-defined with mixed or unilocular radiolucency. A 23-year-old female presented with a swelling in the right mandibular region, radiographs revealed a mixed radiopaque – radiolucent lesion showing a centrifugal expansion. Computed tomography revealed a mixed predominantly opaque expansile lesion with massive buccolingual expansion. Complete excision of the lesion was performed and histopathology findings confirmed it as Cemento-Ossifying Fibroma. Through this case report we want to signify the importance of diagnosis, consecutive therapy after clinical and radiographic findings, as such lesions continue expanding and may lead to a severe medical complication. The knowledge of the different types of radiological findings is important. The unique radiographic appearance of the lesion, in this case, can be beneficial to help clinicians understand. Due to the good delimitation of the lesion surgical removal and curettage is the treatment of choice. Complete surgical resection of the lesion is essential to achieve good results in terms of health and recurrence.

Conservative surgical management of Juvenile Central Cemento- Ossifying Fibroma of anterior mandible. - Case report and literature review

Cemento-ossifying fibroma (COF) is a benign neoplasm that arises from the periodontal membrane which contains multipotential cells that are capable of forming cementum, lamellar bone and fibrous tissue. Juvenile cemento-ossifying fibroma is a type of fibro osseous lesion which contains cementoid tissue and developed in first two decades of life. Majority of the juvenile COF are aggressive in nature that necessitates extensive radical surgery to prevent the recurrence. This case report describes the conservative surgical management of juvenile cemento- ossifying fibroma in an 8 year old child with the preservation of permanent teeth and long term follow up. Key words: Anterior mandible, Cemento-ossifying fibroma , Fibro osseous lesion, Juvenile osseous neoplasm, Periodontoma

The importance of clinical and radiological findings for the definitive histopathologic diagnosis of benign fibro-osseous lesions of the jaws: Study of 276 cases

PurposeBenign fibro-osseous lesions (BFOLs) are heterogeneous intraosseous disease processes sharing overlapping histopathologic features and demonstrate a wide range of biological behavior. The aim of this study is to highlight the importance of clinical and radiological findings for the definitive histopathologic diagnosis of benign fibro-osseous lesions of the jaws. Materials and MethodsThis is a cross-sectional retrospective study evaluating the three main groups of BFOLs: Cemento-osseous dysplasia, ossifying fibromas, and fibrous dysplasia. Previously diagnosed BFOL cases were searched for thoroughly from the archives of Istanbul University, Institute of Oncology, Department of Tumor Pathology in between 2005 and 2015. Clinical and radiological data of these cases were identified and recorded. The histopathologic features were reevaluated from the H&E-stained slides. ResultsA total of 276 BFOL cases were identified and reevaluated for the study. The most common BFOL type was cemento-osseous dysplasia (n = 135), followed by cemento-ossifying fibroma (n = 77), fibrous dysplasia (n = 53) and juvenile ossifying fibroma (n = 11). The female/male ratio was 3.4:1 with a strong predilection for the 4th decade (n = 102). The mandible (n = 209) was the predominantly affected jaw. Prominent osteoblastic rimming around the bony lesion was commonly observed for cemento-ossifying fibroma (n = 60/77), followed by cemento-osseous dysplasia (n = 23/135). Predominant ossification patterns showed some differences among the groups. The most common radiological feature was the mixed radiolucent/radiopaque internal structure. ConclusionOur results document various clinical, radiological and histopathologic findings of BFOLs. Even some histopathologic differences are observed, clinical and radiographic correlation is mandatory prior to the definitive histopathologic diagnosis of BFOLs for the prevention of possible misdiagnoses or inappropriate treatments.

Mandibular Reconstruction with Autogenous Graft After Surgical Treatment of Cemento-Ossifying Fibroma: a Case Report and Literature Review

Fibro-bone lesions (LFO) are defined as a group of lesions characterized by the replacement of normal bone tissue with fibrous connective tissue, of variable cellularity, permeated by a variable amount of mineralized material, whose microscopic appearance may resemble bone, cement or a mixture of both. Among the injuries that make up this group, we can mention: fibrous dysplasia, ossifying fibroma, bone dysplasia and cemento-bone dysplasia. In this case report, we presented a mandibular reconstruction with free autogenous graft from the iliac crest, with the use of stereolithography prototyping, after the surgical treatment of a cemento-ossifying fibroma, as well as to describe the clinical, epidemiological, radiographic characteristics, and histological, the differential diagnosis and the form of treatment of the referred pathology.

Cemento Ossifying Fibroma: A Pathological Entity

Cemento-ossifying fibroma is a controversial term because of its terminology and its diagnosis. Cemento-ossifying fibroma is odontogenic in origin although it is a central neoplasm of bone and involving the periodontium. Most Cemento-ossifying fibromas exhibit slow and expansile growth in the jaws and are benign in origin. The lesion is encapsulated with mixed radiodensties. The Cemento-ossifying fibroma is characterized by replaced of normal bone by fibrous tissue and varying amounts of osteoid and cementum like material. The definitive diagnosis of such lesions require clinical, radiological and histopathological observations. The treatment of choice is surgical resection and recurrence in uncommon. We report a case of Cemento ossifying fibroma in left mandibular premolar region and discuss how to confirm the diagnosis.

Spheno-orbital juvenile psammomatoid ossifying fibroma: a case report and literature review

Ossifying fibroma (OF) is an uncommon benign fibro-osseous lesion. Based on its clinical, morphological, and radiological features, OF is further divided into cemento-ossifying fibroma (COF), juvenile psammomatoid ossifying fibroma (JPOF), and juvenile trabecular ossifying fibroma (JTOF). JPOF rarely involves the cranial base, with limited reports published on spheno-orbital JPOF. In this paper, we report a case of JPOF of the greater wing of the sphenoid bone and lateral orbital wall in an 11-year-old child and show a surgical video. Although rare, JPOF should be considered in the differential diagnosis of fibro-osseous lesions of the spheno-orbital region.

Cemento-ossifiying fibroma of the maxilla: A rare case report

ABSTRACT Introduction: Benign fibro-osseous lesions of the jaw are often a problem in diagnosis and classification. Cemento ossifying fibroma is one of the odontogenic tumor fibro-osseous lesions originating from the periodontal ligament's remaining cells, which occurs in the jaw and is rarely found. These lesions are often clinically and radiographically similar to other fibro-osseous lesions of the jaw. This case report aims to discuss its clinical, radiological, and histopathological features of cemento-ossifying fibromas that are often confused with other fibro-osseous lesions. Case Report: A 53 years old man reported to the Department of Oral Maxillofacial Surgery, Hasan Sadikin General Hospital, with a chief complaint that had lumped in his right upper jaw. About four years ago, a 2x2x2 cm lump appeared around the right maxillary gum after trauma from brushing, the lump did not hurt, and the patient did not seek any treatment. Approximately three months ago, the lump was getting bigger without pain, uncomfortable because it filled the oral cavity with a clinical picture of a lump on the palate that does not bleed easily without pain, the color of the lump is the same as the surrounding tissue, and there is no ulcer. At first, the patient was diagnosed with peripheral ossifying fibroma. Histopathological examination results showed cemento ossifying fibroma. The therapy is excision. Conclusion: Cemento ossifying fibroma is fibro-osseous lesions that develop from the periodontal ligament and are composed of cementum, bone, and fibrous tissue. In this case, the result of the histopathological examination is a definitive diagnosis.

Cemento-ossifying fibroma: A diagnostic dilemma

Cemento-ossifying fibroma (COF) is a controversial term because of its terminology and its diagnosis. The COF is odontogenic in origin, although it is a central neoplasm of the bone and involves the periodontium. Most COFs exhibit slow and expansile growth in the jaws and are benign in origin. The lesion is encapsulated with mixed radiodensities. The COF is characterized by the replacement of normal bone by fibrous tissue and varying amounts of osteoid and cementum-like material. The definitive diagnosis of such lesions requires clinical, radiological, and histopathological observations. The treatment of choice is surgical resection, and recurrence is uncommon. We report a case of COF in the left mandibular premolar region and discuss how to confirm the diagnosis.

Retka prezentacija cemento-osificirajućeg fibroma u maksili - prikaz slučaja

The basis of the problem: Cemento-ossifying fibroma is a benign fibro-osseous lesion of the jaw. It presents as a slow growing swelling which progressively enlarges if not surgically intervened. Cemento-ossifying fibroma revolves around the use of different terminologies and diagnostic criteria in proposing a strategic treatment plan. Method: The current article describes a rare occurrence of cement-ossifying fibroma affecting maxilla in a 44 year old female patient. Clinically, the lesion was painless and slow growing in nature. Computed tomography revealed a hypodense area in the right posterior maxilla measuring 19.07mm X 27.11mm. The lesion was surgically resected under general anesthesia and it was histopathologically confirmed to be cemento-ossifying fibroma. Results: Total enucleation/ resection of the osseous lesion must be timely ensured to prevent recurrence and also to achieve good prognosis which was done in the described case report. No recurrence was reported in the present case which had a follow up for 24 months. Conclusion: Although numerous controversies exist in the use of terminologies, a multi centric approach mandates to correlate clinically, radiographically and histologically to determine the treatment perspective.

Cemento-Ossifying Fibroma: Clinical, Radiological and Histopathological Findings

Cemento-ossifying fibroma, which is considered a benign mesenchymal odontogenic tumour of the jaws, is a type of fibro-osseous lesion characterized by slow growth and proliferation of fibrous cellular stroma containing osteoid, bone or cementum-like tissue. The aim of this study was to report a case of cemento-ossifying fibroma in the mandible with clinical, radiological, and histopathological findings and surgical treatment. A 37-year-old woman was admitted to our clinic with the complaint of gradually growing painless swelling in the right mandibular premolar area. Intra-oral examination revealed a bony hard and non-tender mass with intact overlying mucosa on the buccal and lingual aspects of the mandibular right premolar teeth. Periapical, panoramic, and cone beam computed tomography images revealed the presence of a multilocular hypodense lesion with bicortical destruction and expansion in the relevant area. Excisional biopsy of the lesion was performed and histopathological examination exhibited the definite diagnosis of cemento-ossifying fibroma. Clinical, radiological, and histopathological examination should be considered in the diagnosis and treatment planning of cemento-ossifying fibroma.

Analogous feature of cemento-ossifying fibroma and bone pathology: a clinico-pathological correlation

Intra-osseous pathology of the craniofacial region is microscopically characterized by hypercellular fibroblastic stroma with a variable amount of bone or cementum like calcified structures. The overlapping histopathological features are not limited to lesions under one classification of similar origin rather it imbricates the lesions of entirely different origin as well. The only possible way out then becomes the clinicopathological correlation. Hence, in an out of entire clinical, a radiographic, surgical, and histopathological feature reframes the building block for confirmatory diagnosis of a bone lesion.

Cemento-Ossifying Fibroma of Maxilla: An Unusual Case Report

Cemento-ossifying fibroma (COF) is a benign fibro-osseous lesion which belongs to the same category of fibrous dysplasia and cement-ossifying dysplasia. It arises from the periodontal membrane which contains multipotent cells that are capable of forming cementum, lamellar bone, and fibrous tissue. It is more common in the mandible than in the maxilla. We present a case of COF in the maxilla, a rare occurrence in a 66-year-old female with the chief complaint of a swelling in the left upper back tooth region for the past 3 years. A panoramic radiograph was taken, which showed an oval radiopaque lesion in the second quadrant from 24 to maxillary tuberosity. In the maxilla, the clinical and radiological differential diagnosis includes fibrous dysplasia, giant cell lesions, cementoblastoma, calcifying epithelial odontogenic tumor, and peripheral giant cell granuloma. It is sharply circumscribed and demarcated from the surrounding bone, so surgical excision is the treatment of choice.

Cemento-ossifying fibroma: Case report

Ossifying fibroma (OF) is a benign, non-odontogenic tumor of the jaw, and it is classified as fibro-osseous lesion of jaw. Earlier, the lesion was sub classified histologically into ossifying fibroma and cementifying fibroma according to the hard tissues formed either bone or cementum. Menzel in 1872 called it as cemento-ossifying fibroma (COF). This lesion is included in the group of mesodermal odontogenic tumors and usually present as a gradually growing lesion that might achieve enormous size with resultant deformity, if not treated. The tumor may grow quite extensively; thus, the term “aggressive” is occasionally applied. In this article, A case of cemento-ossifying fibroma involving the left side of mandible is described in a 25 year-old female patient. The clinical, radiographic, histologic features are described and several differential diagnoses are discussed.

A firm mass of the maxillary gingiva

A firm mass of the maxillary gingiva

Peripheral cemento-ossifying fibroma associated with TUBEROUS SCLEROSIS

Peripheral cemento-ossifying fibroma associated with TUBEROUS SCLEROSIS

ABC IN AN INNOCUOUS OSSIFYING FIBROMA – A CASE REPORT

Ossifying fibroma is a rare, slow-growing, benign, non-odontogenic tumour of the jaw seen in the head and neck region. This article presents the case of residual cyst in the right-side mandibular region of a 38-year old female patient. The patient gave a history of swelling in the right lower back tooth region (46- FDI system) which was diagnosed as missing tooth of a previous extraction done 4 years back. Clinically and radiographically, the lesion resembled residual cyst of odontogenic origin whereas histopathologically the examination revealed, a diagnosis of Ossifying Fibroma with aneurysmal bone cystic degeneration which mimic and masqueraded each other. KEYWORDS Cemento-ossifying fibroma, Residual cyst, Fibro-osseous lesion.

Cemento-ossifying fibroma of the mandible: a case report

Background: Cemento-ossifying fibroma (COF) is a relatively rare benign nonodontogenic fibro-osseous lesion, which arises from the mesenchymal blast cells of the periodontal ligament and involves immature bone trabeculae and cementoid formations. Case Presentation: A 45-year-old female patient presented with a unilocular lesion placed in the posterior region of the mandible. Uniform, rounded swelling was present in the buccal vestibule of the mandible. Clinical, radiologic, and histologic features of COF are discussed in this article. Conclusion: Although the COF etiology is not exact as yet, clinicians may keep in mind that tooth extraction history may accompany COF, as seen in this case.

Odontogenic tumours in a Chilean population: a retrospective study of 544 cases based on 2022 WHO classification.

Odontogenic tumours are infrequent lesions. Studies on the frequency of odontogenic tumours from Latin America are scarce. This work aimed to determine the relative frequency of odontogenic tumours in a Chilean population using the 2022 World Health Organization classification. This is a case series retrospective study. We reviewed 35,530 samples from 1975 to 2022 from the Oral Pathology Referral Institute and the Pathological Anatomy Service, Faculty of Dentistry, University of Chile. We utilized the 2022 World Health Organization classification for histological typification. According to 2022 World Health Organization classification, 544 odontogenic tumours were confirmed. The most frequent odontogenic tumours were: odontoma (n=241; 44.3%), ameloblastoma (n=109; 20.0%) and cemento-ossifying fibroma (n=71; 13.1%). Benign odontogenic tumours corresponded to 538 cases (98.9%) and malignant tumours were only six cases (1.1%). In our population, odontoma was the most frequent odontogenic tumour followed by ameloblastoma and cemento-ossifying fibroma. Malignant odontogenic tumours were very rare. The results of this study are similar to reports from America, but there are some differences concerning the data from Africa and Asia.