Cellulose Membrane Research Articles

In situ generated CdS on mixed cellulose membrane matrix as an easily recyclable photocatalyst for mineral flotation wastewater treatment

In situ generated CdS on mixed cellulose membrane matrix as an easily recyclable photocatalyst for mineral flotation wastewater treatment

A functionalized Sup35NM nanofibril-assisted oriented antibody capture in lateral flow immunoassay for sensitive detection of dengue type II NS1.

Rapid and sensitive dengue non-structural protein 1 (NS1) detection assay is essential for the treatment of disease and currentlyreleases high medical cost burdens. To address the limitations of conventional LFIA strips, we have developed an improved Sup35NM-Z-based LFIA that immobilizes antibodies on cellulose membranes in an orientated manner to increase the sensitivity of LFIA strips. A dual-functional Sup35NM nanofibril was fabricated by fusion with the antibody binding domain; resultant nanofibril from the amyloid Sup35NM was sprayed on the T-line to orientate the capture antibody and produces fluorescence signals. Antibody binding analysis showed that self-assembly of the Sup35NM monomer does not affect the binding activity of the Z-domain with the antibody. The NS1 for DENV-2 infection was chosen as a model target antigen to assess the feasibility of the Sup35NM-Z-domain-based LFIA platform. Under optimal conditions, the Sup35NM-Z-domain-based LFIA detected NS1 within 15 min with a detection limit of 1.29 ng/ml, while the detection limit of traditional LFIA with the same concentration of anti-NS1-Ab1 on the T-line by conventional physical adsorption was 2.20 ng/ml, 1.7 times higher than that of Sup35NM-Z-domain-based LFIA. As compared to traditional LFIAs, the Sup35NM-Z-based LFIA had a wide detection range of 1.29-625 ng/mL. The LFIA's clinical performance in identifying NS1 was also assessed using 15 clinical samples. The LFIA accurately recognized positive and negative samples, equal to 86.7% accuracy. The developed Sup35NM-Z-domain-based LFIA in this study offers great potential for the identification of target markers because of its greatly improved sensitivity and wider detection range.

Bacterial Cellulose-Based Bandages with Integrated Antibacteria and Electrical Stimulation for Advanced Wound Management.

Bandages for daily wounds are the most common medical supplies, but there are still ingrained defects in their appearance, comfort, functions, as well as environmental pollution. Here, novel bandages based on bacterial cellulose (BC) membrane for wound monitoring and advanced wound management are developed. The BC membrane is combined with silver nanowires (AgNWs) by using vacuum filtration method to achieve transparent, ultrathin (≈7 µm), breathable (389.98-547.79gm-2 d-1 ), and sandwich-structured BC/AgNWs bandages with superior mechanical properties (108.45-202.35 MPa), antibacterial activities against Escherichia coli and Staphylococcus aureus, biocompatibility, and conductivity (9.8 × 103 -2.0 × 105 Sm-1 ). Significantly, the BC/AgNWs bandage is used in the electrical stimulation (direct current, 600 microamperes for 1 h every other day) treatment of full-thickness skin defect in rats, which obviously promotes wound healing by increasing the secretion of vascular endothelial growth factor (VEGF). The BC bandage is used for monitoring wounds and achieve a high accuracy of 94.7% in classifying wound healing stages of hemostasis, inflammation, proliferation, and remodeling, by using a convolutional neural network. The outcomes of this study not only provide two BC-based bandages as multifunctional wound management, but also demonstrate a new strategy for the development of the next generation of smart bandage.

Study on the structure characterization and swelling properties of the Fe3O4/CMS composite membrane

ABSTRACT In order to improve the functionality of cellulosic materials research and development of high performance soluble materials. Therefore, the Fe3O4/CMS composite membrane was prepared by using carboxymethyl salix powder (CMS) and Fe3O4 as raw materials, 1-propenyl-3-methylimidazolium chloride and dimethyl sulfoxide as dissolution system. The effects of swelling time, swelling temperature, pH and ionic strength on the swelling performance of Fe3O4/CMS composite membranes and the swelling kinetics of the composite membranes were studied. The structure of the composite membrane was characterized by SEM, FT-IR, XRD and TG. The results showed that the swelling degree reached 5.54 g·g−1, when the swelling time was 45 min, the swelling temperature was 65°C, the pH was 5 and the ionic strength was 0.08 mol·L−1. The initial phase of dissolution of the composite membrane fits well with the Fickian diffusion model, and the whole dissolution process belongs to the Schott model, indicating that the main role of the dissolution process is the diffusion of water molecules, while the composite membrane can be preserved for a long time at high temperature, which provides sustainability for the composite membrane. The characterization results showed that the surface of Fe3O4/CMS composite film was rough with small grooves. The O-H effect was enhanced and the Fe-O absorption peak appeared at 600 cm−1, indicating that Fe3O4 had been successfully loaded onto the cellulose membrane. The Fe3O4/CMS composite membrane belonged to cellulose type II structure, meanwhile, the composite membrane had good thermal stability.

Polydopamine-modified cellulose-based composite separator for inhibiting dendritic growth of lithium metal batteries

The inhomogeneous pore structure and lack of polar groups in lithium metal battery separators lead to uneven transport of Li+ through the separator, the uneven flux of Li+, and eventually the formation of lithium dendrites. Therefore, to provide uniform Li+ transport and inhibit the growth of lithium dendrites, a polydopamine-modified cellulose membrane (PDA-CM) was created by oxidative self-polymerizing dopamine and binding it to the surface and interface of the cellulose membrane through hydrogen bonds. The successful preparation of the PDA-CM separator by PDA-modified cellulose membrane by hydrogen bonds was proved by the FT-IR test. TGA, thermal shrinkage test, tensile strength test, FESEM, and porosity test results indicated that neither the PDA-CM nor the CM separators shrank at 160 °C, the PDA-CM separator also had better tensile strength (Stress = 31.1 MPa), and uniform pores (Porosity = 54.95 %) with homogeneous Li+ flux. The polar functional groups (-NH- and -OH) in PDA improved the electrolyte uptake rate (Electrolyte uptake rate = 469.77 %), the electrolyte retention (Electrolyte retention = 409.04 %), and electrolyte wettability (Contact angle = 18.35°) of the separator and promoted the uniform distribution of Li+ through the PDA-CM separator. In addition, the PDA-CM separator had better ionic conductivity (1.54 × 10−3 S·cm−1) and lower impedance (849 Ω). The catechol on the PDA molecule created strong adhesion between the separator and the lithium metal, reduced the local tension on the surface of the lithium metal and inhibited dendrite growth. The lithium metal anode remained smooth after cycling. The lithium metal battery prepared by the PDA-CM separator showed decent cycle performance and remained a high capacity retention rate (90.48 %) after 100 cycles. This study provides a new solution for the modification of cellulose-based lithium metal battery separators, which can achieve uniform transmission of Li+, inhibit the growth of lithium dendrites, and improve battery performance.

Molecular self-assembled cellulose enabling durable, scalable, high-power osmotic energy harvesting

In recent years, renewable cellulose-based ion exchange membranes have emerged as promising candidates for capturing green, abundant osmotic energy. However, the low power density and structural/performance instability are challenging for such cellulose membranes. Herein, cellulose-molecule self-assembly engineering (CMA) is developed to construct environmentally friendly, durable, scalable cellulose membranes (CMA membranes). Such a strategy enables CMA membranes with ideal nanochannels (∼7 nm) and tailored channel lengths, which support excellent ion selectivity and ion fluxes toward high-performance osmotic energy harvesting. Finite element simulations also verified the function of tailored nanochannel length on osmotic energy conversion. Correspondingly, our CMA membrane shows a high-power density of 2.27 W/m2 at a 50-fold KCl gradient and super high voltage of 1.32 V with 30-pair CMA membranes (testing area of 22.2 cm2). In addition, the CMA membrane demonstrates long-term structural and dimensional integrity in saline solution, due to their high wet strength (4.2 MPa for N-CMA membrane and 0.5 MPa for P-CMA membrane), and correspondingly generates ultrastable yet high power density more than 100 days. The self-assembly engineering of cellulose molecules constructs high-performance ion-selective membranes with environmentally friendly, scalable, high wet strength and stability advantages, which guide sustainable nanofluidic applications beyond the blue energy.

Molecular Self‐Assembly of Au Nanoparticles on a Porous Cellulose Membrane Template for Highly Sensitive Colorimetric Detection of Glucose

AbstractA sensitive glucose colorimetric detection system (Au@QCM) based on quaternized cellulose membrane (QCM) and enzyme‐mimicking Au nanoparticles (AuNPs) was successfully developed via a simple molecular self‐assembly strategy. The positively charged QCM functioned as a template to guide the negatively charged citric acid‐reduced AuNPs uniformly distributed on the surfaces along the pore walls of its porous structure, and thus gave AuNPs an ordered interconnected three‐dimensional network. This electrostatic interaction could effectively prevent the aggregation of the AuNPs and greatly increase their exposed surface area, thus endow the Au@QCM with highly active catalytic properties towards glucose oxidation with glucose oxidase (GOx). The experimental studies showed that the color change of redox indicator 3,3′,5,5′‐tetramethylbenzidine (TMB) can be clearly observed with naked eyes and the absorbance of the oxidized TMB (at 653 nm) was directly proportional to the concentration of glucose. Au@QCM could achieve a sensitive glucose detection with a limit of detection of 0.55 μM and linear response in the range of 0.01–0.5 mM. Besides, it also had good applicability in real samples detection and excellent selectivity to glucose. This novel detection system significantly improved detection performance compared to previous work based on cellulose‐based strips loaded with GOx and horseradish peroxides.

MOFs and surface modification synergistically modulated cellulose membranes for enhanced water permeability and efficient tellurium separation in wastewater

With the widespread use of tellurium-containing products such as cadmium telluride solar cells in daily life, tellurium-containing wastewater inevitably enters the environmental water system. Removal of the ionic contaminant tellurite is essential in wastewater reclamation due to its potential threat to human health and difficulty of elimination. Herein, a rational design of separation membranes with synergistic physical and chemical effects to enhance separation efficiency with almost complete compensation for the loss of water flux was proposed. Membranes for tellurium separation with high efficiency and enhanced water flux were prepared by surface modification on the MOF-based support layer forming a dense separation layer (TSNTCM). The membrane separation efficiency was enhanced by the introduction of NH2-MIL-125 in the support layer, while the water flux was improved by its nano water channels. The abundant hydroxyl and anionic groups in the structure of the polymer monomer sodium lignosulfonate not only endowed the separation layer with chemical interaction (hydroxyl substitution), but also made the membrane surface highly negatively charged and improved the physical interaction. TSNTCM showed excellent tellurium separation efficiency (>95%) over a wide concentration range and achieved the highest rejection (99.16%) at pH = 6. Besides, the rejection of tellurium by TSNTCM was above 90% in the presence of common coexisting ions, but decreased in the presence of selenite, which may be due to the similar structure and properties of selenite and tellurite. Moreover, TSNTCM demonstrated satisfactory reusability and anti-fouling properties. Overall, MOFs and surface modification enhanced the comprehensive performance of TSNTCM, providing great potential for its application in wastewater reclamation.

A colorimetric sensor array based on transparent photographic film (triacetyl cellulose polymer) as a smart label for naked eye detection of chicken meat spoilage

A new transparent colorimetric sensor array is presented for naked eye monitoring of the chicken meat freshness. This sensor array consists of four sensors fabricated by using pH indicators, immobilized on triacetyl cellulose (TAC) membrane. The sensor array represented obvious color change when it was exposed to the volatile organic compounds emitted from the chicken meat after 20 h keeping at room temperature or after four days of storage in the refrigerator. Therefore, it could easily identify spoiled meat from the fresh one assisted by chemometrics data analysis. Also, the color change of sensors due to the spoilage was sharp enough that could be read even by untrained people, providing naked eye monitoring the chicken meat freshness. The TAC polymer represented high physical stability for industrial scale-up. In addition, the immobilized indicators represented good stability against color change in humid condition. This offered the potential for continuous monitoring of the meat spoilage as smart labeling in the markets.

Simultaneous generation and immobilization of silver nanoparticles on cellulose membranes by hydrogen bond-assisted in-situ reaction for colorimetric detection of mercury ions and hydrogen peroxide

The present study has verified that silver nanoparticles (AgNPs) can be simultaneously generated and immobilized in the micro-nanopores of regenerated cellulose membranes (CMs) via a simple in-situ synthesis, which can be used for colorimetric detection of mercury ions (Hg2+) and hydrogen peroxide (H2O2). The findings showed that the high-loose interpenetrating porous structure and abundant hydroxyl groups of CMs can serve as both micro-reaction spaces and immobilized sites for the in-situ synthesis of AgNPs. The Ag@CMs, composed of well-dispersed, firmly-fixed, and quantity controlled AgNPs functionalized CMs, have excellent Hg2+ colorimetric detection capabilities with a visual limit of detection (VLOD) as low as 5 nM. It can efficiently complete early-warning and semi-quantitative Hg2+ recognition, and exhibits high storage stability for more than 180 days. Moreover, the Ag@CMs exhibited peroxidase mimic behavior and catalyzed the oxidation reaction of 3,3,5,5-tetramethylbenzidine (TMB) by H2O2 to produce a blue solution. This work proposes a simple “green” approach for the heterogeneous synthesis of controllable and stable AgNPs immobilized on CMs and explores their application in chemosensing.

Carboxymethyl cellulose/Zn-based metal organic frameworks membranes for pervaporation-assisted esterification reactor

Pervaporation membrane reactors attract much attention as a promising system, in which separation and reaction are carried out simultaneously to overcome the thermodynamic equilibrium limitation and to increase the conversion by removing one or several synthesized products. For this, in this study supported carboxymethyl cellulose (CMC) membranes modified with Zn-based metal organic frameworks (Zn(SEB), Zn(BIM), Zn(BDC)Si) were developed. Transport properties of obtained membranes were evaluated in pervaporation separation of quaternary mixtures (acetic acid (AcOH), ethanol (EtOH), ethyl acetate (EtAc), water) with various compositions. CMC/Zn(BIM) membranes, possessed optimal transport characteristics, were tested in hybrid process “reaction + pervaporation” using batch pervaporation membrane reactor and compared with data obtained in batch reactor without membrane. The changes of structure and physicochemical properties of developed membranes were studied by spectroscopic, microscopic methods, thermogravimetric analysis and measurements of contact angles. To confirm findings obtained, theoretical consideration by computational methods for the CMC/Zn(BIM) membrane was carried out. It was shown that the application of optimal CMC/Zn(BIM)(10 wt%) membrane in pervaporation-assisted esterification reactor led to the formation of more than 5 times larger amount of EtAc in the reactor with decreased AcOH conversion compared to batch reactor without membrane in the separation of esterification reaction AcOH and EtOH (1/1 M) with 5 wt% Amberlyst 15 catalyst at 60 °C.

An intelligent solvent-responsive surface molecularly imprinted membrane with switchable adsorption/desorption performance for selective separation of psoralen and recognition mechanism

Psoralen (PSO), a natural product in Ficus carica L., exhibits remarkable pharmacological activity and clinical efficacy. However, achieving selective recognition and effective recovery in PSO separation process remains a challenge. In this study, an intelligent solvent-responsive surface molecularly imprinted membranes (SR-SMIMs) with switchable adsorption/desorption behavior was developed and applied to separate PSO. Cellulose membranes were modified with chitosan and polydopamine in sequence, followed by the construction of a surface molecularly imprinting layer using bi-functional monomers (AM and 4-VPBA) and solvent-responsive cross-linking agent (TEGDMA). The TEGDMA drives the swelling or shrinking of polymer chains, resulting in a switch in the adsorption/desorption behavior of SR-SMIMs. Hence, SR-SMIMs exhibited remarkable adsorption capacity of 40.69 mg·g-1 towards PSO in 25% methanol and can be efficiently desorbed with satisfactory efficiency in methanol. The molecular simulation and NMR analysis demonstrated that the recognition mechanism of SR-SMIMs was a synergistic effect of hydrogen bonding, π-π stacking and Van der Waals forces. Furthermore, the SR-SMIMs were effectively employed for the separation of PSO from Ficus carica L. leaves, exhibiting an impressive adsorption capacity of 20.51 mg·g-1 and a high elution recovery rate of 92.54%. This efficient and sustainable SR-SMIMs possessed promising potential for specific separation of target compound from complex natural plants extracts.

ZnO@C Coated Cellulose-Based Separators Control Lithium Deposition Direction to Stable Lithium Metal Batteries.

Li metal anodes have attracted attention due to their high specific capacity and low electrochemical potential. Nevertheless, the uncontrolled growth of Li dendrites hinders the practical application of Li metal batteries. Although the various approaches have made performance improvements, safety hazards still exist since Li dendrites are still growing along the anode to the separator during the continuous plating/stripping process. Herein, a straightforward method is proposed to achieve stable Li metal batteries with directional growth control by using a functional ZnO@C/cellulose membrane as a separator. The abundant pore structure and functional groups of biomass cellulose enhance the Li-ion transport and interface compatibility. The ZnO transforms in situ to form a Li-Zn alloy layer which is uniformly coated to the separator to direct uniform ion concentration polarization and charge distribution polarization, control the growth direction of Li, significantly improve the cycling stability, and promote the reversibility of the Li plating/exfoliation process. As a result, the symmetric cell exhibits an extreme lifetime of more than 4500h and low polarization at 3mAcm-2 . The cycling performance of the Li||LiFePO4 full cell reaches a capacity retention of 98% after 270 cycles at a mass loading of 10mgcm-2 .

In situ green synthesis of AgNPs in bacterial cellulose membranes and antibacterial properties of the composites against pathogenic bacteria

In situ green synthesis of AgNPs in bacterial cellulose membranes and antibacterial properties of the composites against pathogenic bacteria

Review: chitosan-based biopolymers for anion-exchange membrane fuel cell application.

Chitosan (CS)-based anion exchange membranes (AEMs) have gained significant attention in fuel cell applications owing to their numerous benefits, such as environmental friendliness, flexibility for structural alteration, and improved mechanical, thermal and chemical durability. This study aims to enhance the cell performance of CS-based AEMs by addressing key factors including mechanical stability, ionic conductivity, water absorption and expansion rate. While previous reviews have predominantly focused on CS as a proton-conducting membrane, the present mini-review highlights the advancements of CS-based AEMs. Furthermore, the study investigates the stability of cationic head groups grafted to CS through simulations. Understanding the chemical properties of CS, including the behaviour of grafted head groups, provides valuable insights into the membrane's overall stability and performance. Additionally, the study mentions the potential of modern cellulose membranes for alkaline environments as promising biopolymers. While the primary focus is on CS-based AEMs, the inclusion of cellulose membranes underscores the broader exploration of biopolymer materials for fuel cell applications.

Bacterial cellulose loaded with silver nanoparticles as a flexible, stable and sensitive SERS-active substrate for detection of the shellfish toxin DTX-1.

Diarrheal shellfish toxins are considered one of the most lethal red tide algae toxins in the worldwide. In this work, we propose an Ag NPs-loaded bacterial cellulose membrane (BCM) surface-enhanced Raman scattering (SERS) sensor based on an aptamer (Apt) for the ultrasensitive detection of dinophysistoxin (DTX-1), a type of diarrheal shellfish toxin. During drying, Ag NPs can be further densified on "gel-like" BCM to form high-density SERS "hot spots". We developed the "Apt-SH@Ag NPs@BCM" SERS sensor and used the competition of DTX-1 and complementary base (Cob) in the process of base complementary pairing to achieve SERS detection of DTX-1, with a minimum detection limit of 9.5×10-10mol/L. Sample assays showed DTX-1 recovery rates ranging from 95.8% and 108.2% and the detection results were comparable to those obtained by LC-MS. Therefore, this work holds great potential for detecting of toxic substances in shellfish products, especially for the oyster (portuguese oyster) and mussel (blue mussel).

Fabrication and floating test of an asymmetric supercapacitor based on polyaniline and MXene

Polyaniline (PANI) exhibits considerable capacitance at positive potentials in acidic aqueous electrolytes, making it a highly promising pseudocapacitive material. Nevertheless, the absence of appropriate anode materials capable of effectively functioning at negative potentials in its asymmetric supercapacitors hinders the ability to increase the cell voltage, thereby impacting the specific energy. To address this issue, MXene (Ti3C2Tx) was utilized due to its proven efficacy in mitigating hydrogen evolution at highly negative potentials in acidic aqueous electrolytes. In this study, we fabricated an asymmetric supercapacitor consisting of a PANI nanorod array deposited on bacterial cellulose (BC) membrane and a MXene/carbon nanotube (MXene/CNT) film. The device can operate at a cell voltage of 1.3 V and exhibits exceptional specific energy and specific power (12.1 Wh kg−1/0.4 kW kg1 and 7.9 Wh kg−1/1.7 kW kg−1). It demonstrates excellent cycling performance, with a capacitance retention rate of 96% after 2000 galvanostatic charge/discharge (GCD) cycles. In addition, one practical and reliable approach, the floating test, was applied to assess the stability of this asymmetric supercapacitor. It also maintains 82% of its initial capacitance after 60 h of floating time. Our findings indicate that the combination of PANI and MXene in an asymmetric configuration represents a promising approach for the development of next-generation PANI-based supercapacitors.

Proton-exchange polymer composite membrane of Nafion and microcrystalline cellulose for performance improvement of direct glycerol fuel cell

In this research, glycerol was used as fuel for a direct glycerol fuel cell (DGFC). Nafion (NF) was used to fabricate a proton exchange membrane and microcrystalline cellulose (MCC) was used as a filler for fabricating the NF composite membranes with different MCC loadings (0, 5, 10, or 15 wt%). The composite membranes were characterized using X-ray diffraction XRD for study of the crystallinity index (CI), SEM-EDS was applied to observe the atom dispersion of membranes, and FTIR-ATR was used to identify the chemical bonds of samples. The results showed that the 15 % MCC/NF membrane had a greater CI than the 5 % MCC/NF composite membrane, while the atom dispersion of the 5 % MCC/NF membrane was better than the others. The composite membrane properties were tested based on water uptake, solubility, ion exchange capacity, chemical degradation, 1 M and 2 M glycerol permeability, proton conductivity, selectivity, and fuel cell performance. The 5 wt% MCC loading increased the water uptake and proton conductivity and decreased the glycerol crossover compared to the other membranes. However, 15 wt% MCC had more durable chemical membrane degradation than the 5 wt% MCC membrane and the solubility test identified that the 5 %, 10 %, and 15 % MCC/NF composite membranes had 2.97, 3.08, and 4.92 times, respectively, that of the recast NF membrane. The highest selectivity (1.54 × 105 Sscm−1) of the membranes was recorded for the 5 % MCC/NF composite membrane at 50 °C. The DGFC performance with 1 M glycerol at 70 °C of the 5 % MCC/NF composite membrane had a maximum power density 18.07 mW/cm2 and a current density 0.139 mA/cm2.

Preparation of SERS base membrane with cellulose compound dopamine and determination of hypochlorite.

Flexible silver substrates were made by in situ reduction of silver nanoparticles in bacterial cellulose membranes using the unique advantage of dopamine. Subsequently, we modified the substrate with 4-mercaptophenol (4-MP), a molecule capable of specifically recognizing ClO-, and its corresponding SERS signal changes with the concentration of hypochlorite, thus allowing the quantitative detection of ClO- content. The method showed a negative linear correlation (R2 = 0.9567) with the SERS intensity at 1077cm-1 over the concentration range 0.5-100µM, and the detection limit was 0.15µM. The RSD of the SERS intensity at 1077cm-1 under five batches was 4.2%, which proved the good reproducibility of P-BCM-Ag NP-MP. Finally, the P-BCM-Ag NPs were used for the detection of hypochlorite in cell contents, artificial urine, and clinical serum samples, utilizing spikeexperiments in all three environments. The recoveries were in the range 90-110% indicating the accuracy of the method for the detection of hypochlorite and validating the promising application of this assay for practical detection in intricate biological samples.

Determination of H2O2 and its antioxidant activity by BCM@Au NPs ratiometric SERS sensor

As a reactive oxygen species (ROS), excessive production of H2O2 contributes to the development of several diseases such as, inflammation, cancer, and respiratory diseases. Supplementation with endogenous or exogenous antioxidants can scavenge ROS and reduce the oxidation of cellular molecules, thus alleviating the generation of diseases. Therefore, the determination of H2O2 content and its antioxidant activity is of great importance in disease diagnosis and treatment. In this paper, a ratiometric SERS sensor with a flexible cellulose membrane was designed for quantitative detection of H2O2 and assessment of antioxidant activity. First, gold seeds were reduced on bacterial cellulose membrane (BCM) and Au NPs were smoothly deposited on the bacterial cellulose membrane (BCM) using halides to reduce the reduction potential in the growth solution to form a flexible BCM@Au NPs SERS substrate. Afterwards, the oxidation of H2O2 was used to convert 3-mercaptophenylboronic acid (3-MPBA) to the corresponding phenol form 3-hydroxyphenylethanol (3-HTP). The change of substance resulted in a good linear relationship between the intensity ratio corresponding to the two Raman shifts of 881 cm−1 and 995 cm−1 and the H2O2 concentration with a detection limit of 0.0186 μM. This opens up a new method for the detection of H2O2 with high sensitivity and accuracy. In addition, this SERS platform was successfully used for the determination of antioxidant activity. It is promising to be applied to disease diagnosis and efficacy evaluation.