This research proposes a fast and accurate method for modeling transient heat transfer in ventilated double-skin façades (VDFs) with forced ventilation to predict their energy-saving potential. Using the thermal quadrupole formalism, the method solves the VDF problem in the Laplace domain while considering the full transient nature of the heat transfer; the only approximation is in space. The solution involves obtaining a general transfer function that predicts heat transfer rates or air temperatures at ventilated cavity's exit. The quadrupole method is validated against computational fluid dynamic numerical simulations conducted under similar meteorological, design and boundary conditions. A very good agreement was found (less than 3 % average deviation) with a significant reduction in computation time (less than 3s against 6h for CFD calculations). The model is computationally efficient and can consider important factors such as the opacity of the walls, construction materials, and air cavity design parameters. Finally, the model allows the assessment of the energy-saving potential of VDFs under various scenarios compared to conventional systems, which helps contributing to more sustainable building design practices. The energy efficiency of a VDF configuration was compared against a conventional wall system. Energy savings of 8.4 and 5.2 % were obtained, in cold and hot climates respectively.