Cavitation Activity Research Articles

Dynamic modeling of cavitation bubble clusters: Effects of evaporation, condensation, and bubble–bubble interaction

We present a dynamic model of cavitation bubbles in a cluster, in which the effects of evaporation, condensation, and bubble–bubble interactions are taken into consideration. Under different ultrasound conditions, we examine how the dynamics of cavitation bubbles are affected by several factors, such as the locations of the bubbles, the ambient radius, and the number of bubbles. Herein the variations of bubble radius, energy, temperature, pressure, and the quantity of vapor molecules are analyzed. Our findings reveal that bubble–bubble interactions can restrict the expansion of bubbles, reduce the exchange of energy among vapor molecules, and diminish the maximum internal temperature and pressure when bursting. The ambient radius of bubbles can influence the intensities of their oscillations, with clusters comprised of smaller bubbles creating optimal conditions for generating high-temperature and high-pressure regions. Moreover, an increase in the number of bubbles can further inhibit cavitation activities. The frequency, pressure and waveform of the driving wave can also exert a significant influence on cavitation activities, with rectangular waves enhancing and triangular waves weakening the cavitation of bubbles in the cluster. These results provide a theoretical basis for understanding the dynamics of cavitation bubbles in a bubble cluster, and the factors that affect their behaviors.

Cavitation cloud formation and surface damage of a model stone in a high-intensity focused ultrasound field

This work investigates the fundamental role of cavitation bubble clouds in stone comminution by focused ultrasound. The fragmentation of stones by ultrasound has applications in medical lithotripsy for the comminution of kidney stones or gall stones, where their fragmentation is believed to result from the high acoustic wave energy as well as the formation of cavitation. Cavitation is known to contribute to erosion and to cause damage away from the target, yet the exact contribution and mechanisms of cavitation remain currently unclear. Based on in situ experimental observations, post-exposure microtomography and acoustic simulations, the present work sheds light on the fundamental role of cavitation bubbles in the stone surface fragmentation by correlating the detected damage to the observed bubble activity. Our results show that not all clouds erode the stone, but only those located in preferential nucleation sites whose locations are herein examined. Furthermore, quantitative characterizations of the bubble clouds and their trajectories within the ultrasonic field are discussed. These include experiments with and without the presence of a model stone in the acoustic path length. Finally, the optimal stone-to-source distance maximizing the cavitation-induced surface damage area has been determined. Assuming the pressure magnitude within the focal region to exceed the cavitation pressure threshold, this location does not correspond to the acoustic focus, where the pressure is maximal, but rather to the region where the acoustic beam and thereby the acoustic cavitation activity near the stone surface is the widest.

The relationship between surface drug distribution of Dox-loaded microbubbles and drug release/cavitation behaviors with ultrasound

Ultrasound (US)-triggered microbubbles (MBs) drug delivery is a promising tool for noninvasive and localized therapy. Several studies have shown the potential of drug-loaded MBs to boost the delivery of therapeutic substances to target tissue effectively. Nevertheless, little is known about the surface payload distribution affecting the cavitation activity and drug release behavior of the drug-loaded MBs. In this study, we designed a common chemodrug (Doxorubicin, Dox)-loaded MB (Dox-MBs) and regulated the payload distribution as uniform or cluster onto the outer surface of MBs. The Dox distribution on the MB shells was assessed by confocal fluorescence microscopic imaging. The acoustic properties of the Dox-MBs with different Dox distributions were evaluated by their acoustic stability and cavitation activities. The payload release and the fragments from Dox-MBs in response to different US parameters were measured and visualized by column chromatography and cryo-electron microscopy, respectively. By amalgamating these methodologies, we found that stable cavitation was sufficient for triggering uniform-loaded MBs to release their payload, but stable cavitation and inertial cavitation were required for cluster-loaded MBs. The released substances included free Dox and Dox-containing micelle/liposome; their portions depended on the payload distribution, acoustic pressure, cycle number, and sonication duration. Furthermore, we also revealed that the Dox-containing micelle/liposome in cluster-loaded MBs had the potential for multiple drug releases upon US sonication. This study compared uniform-loaded MBs and cluster-loaded MBs to enhance our comprehension of drug-loaded MBs mediated drug delivery.

Comparative Study of Histotripsy Pulse Parameters Used to Inactivate Escherichia coli in Suspension.

Bacterial loads can be effectively reduced using cavitation-mediated focused ultrasound, or histotripsy. In this study, gram-negative bacteria (Escherichia coli) in suspension were used as model bacteria to evaluate the effectiveness of two regimens of histotripsy treatments: cavitation histotripsy (CH) and boiling histotripsy (BH). Ten-milliliter volumes of Escherichia coli were treated at different negative focal pressure amplitudes and over time periods up to 40 min. Cavitation activity was characterized with coaxial passive cavitation detection (PCD) and synchronized plane wave B-mode imaging. CH treatments exhibited a threshold behavior that was consistent with PCD metrics of cavitation. Above the threshold, bacterial inactivation followed a monotonically increasing log-linear relationship that indicated an exponential inactivation rate. BH exhibited no threshold, but instead followed a different monotonically increasing inactivation rate. Inactivation rates were larger for BH at or below the CH threshold, and larger for CH substantially above the threshold. CH studies performed at different pulse lengths at the same duty cycle had similar inactivation rates, suggesting that at any given pressure amplitude, the "on time" was the most important variable for inactivating E. coli. The maximum inactivation was produced by CH at the highest pressure amplitudes used, leading to a log reduction >4.2 for a 40 min treatment. The results of this study suggest that both CH and BH can be used to inactivate E. coli in suspension, with the optimal regimen depending on the attainable peak negative focal pressure at the target.

Sonosensitive Cavitation Nuclei—A Customisable Platform Technology for Enhanced Therapeutic Delivery

Ultrasound-mediated cavitation shows great promise for improving targeted drug delivery across a range of clinical applications. Cavitation nuclei—sound-sensitive constructs that enhance cavitation activity at lower pressures—have become a powerful adjuvant to ultrasound-based treatments, and more recently emerged as a drug delivery vehicle in their own right. The unique combination of physical, biological, and chemical effects that occur around these structures, as well as their varied compositions and morphologies, make cavitation nuclei an attractive platform for creating delivery systems tuned to particular therapeutics. In this review, we describe the structure and function of cavitation nuclei, approaches to their functionalization and customization, various clinical applications, progress toward real-world translation, and future directions for the field.

A mechanistic study identifying improved technology critical metal delamination from printed circuit boards at lower power sonications in a deep eutectic solvent

Deep eutectic solvents (DESs) are an emerging class of ionic liquids that offer a solution to reclaiming technology critical metals (TCMs) from electronic waste, with potential for improved life cycle analysis. The high viscosities typical of DESs, however, impose mass transport limitations such that passive TCM removal generally requires immersion over extended durations, in some cases in the order of hours. It is postulated that, through the targeted application of power ultrasound, delamination of key structures in electronic components immersed in DESs can be significantly accelerated, thereby enabling rapid recovery of TCMs. In this paper, we fully characterise cavitation in a Choline Chloride-Ethylene Glycol DES as a function of sonotrode input power, by the acoustic detection of the bubble collapse shockwave content generated during sonications at more than 20 input powers over the available range. This justifies the selection of two powers for a detailed study of ultrasonically enhanced TCM-delamination from printed circuit boards (PCBs). Dual-perspective high-speed imaging is employed, which facilitates simultaneous observation of TCM removal, and the cavitation evolution and interaction with the PCB surface. Bubble jetting is identified as a key contributor to initial pitting of the TCM layers, exposing the larger underlying copper layer, with the contributions of additional inertial cavitation-mediated phenomena such as bubble-collapse shockwaves also demonstrated as important for delamination. Optimal cavitation activity throughout the sonication then promotes etching of the copper base layer of the PCB structure targeted by the DES, liberating the overlaying TCMs in sections as large as 0.79 mm2. We report a thirtyfold improvement in processing time compared to passive delamination, with sonications at the lower power outperforming those at the higher power. The results demonstrate the potential for industrially scalable recovery of TCMs from the growing quantities of global e-waste, using combined power ultrasonics and DESs.

Mapping of 20 L capacity ultrasonic reactor using cavitation activity meter and dye degradation

Mapping of a novel 20 L capacity ultrasonic (US) reactor having a total of 44 transducers was done by measuring the local cavitation intensity using a cavitation activity meter at different horizontal planes and subsequent validation based on dye degradation. A fixed frequency of 33 kHz and temperature of 30 °C was used during the mapping performed at two different power levels of 250 W and 400 W. In addition, the mapping of specific plane 2 was also performed with transducers operating on walls 1 and 3, while switching the transducers on walls 2 and 4 off and vice versa so as to establish the role of using multiple transducers. Degradation of RO4 dye was also measured at the plane 2 at various powers as 250 W, 400 W, and 1000 W. The degradation of the RO4 dye directly correlated to the cavitation intensity measured at the various location inside the US reactor. The average cavitation intensity was 265.38, 317.25, 185, and 300.5 Cavins for power dissipations of 250 W, 400 W, 250 W (wall 1 and 3 transducers in operation), and 400 W (wall 2 and 4 transducers in operation), respectively. Correspondingly, the average degradation was 10.35 %, 13.03 %, 5.52 %, and 8.9 % for same sequence of operational power and transducers. The investigation amply illustrated dependency of the cavitational activity on the location, power dissipation, and operating mode elucidating important design related information useful for scale up of sonochemical reactors.

Quantifying the Effect of Acoustic Parameters on Temporal and Spatial Cavitation Activity: Gauging Cavitation Dose.

Cavitation-enhanced delivery of therapeutic agents is under development for the treatment of cancer and neurodegenerative and cardiovascular diseases, including sonothrombolysis for deep vein thrombosis. The objective of this study was to quantify the spatial and temporal distribution of cavitation activity nucleated by Definity infused through the EKOS catheter over a range of acoustic parameters controlled by the EKOS endovascular system. Three insonation protocols were compared in an in vitro phantom mimicking venous flow to measure the effect of peak rarefactional pressure, pulse duration and pulse repetition frequency on cavitation activity energy, location and duration. Inertial and stable cavitation activity was quantified using passive cavitation imaging, and a metric of cavitation dose based on energy density was defined. For all three insonation protocols, cavitation was sustained for the entire 30min Definity infusion. The evolution of cavitation energy during each pulse duration was similar for all three protocols. For insonation protocols with higher peak rarefactional acoustic pressures, inertial and stable cavitation doses also increased. A complex relationship between the temporal behavior of cavitation energy within each pulse and the pulse repetition frequency affected the cavitation dose for the three insonation protocols. The relative predominance of stable or inertial cavitation dose varied according to insonation schemes. Passive cavitation images revealed the spatial distribution of cavitation activity. Our cavitation dose metric based on energy density enabled the impact of different acoustic parameters on cavitation activity to be measured. Depending on the type of cavitation to be promoted or suppressed, particular pulsing schemes could be employed in future studies, for example, to correlate cavitation dose with sonothrombolytic efficacy.

Numerical study of static pressure on the sonochemistry characteristics of the gas bubble under acoustic excitation

Abstract The extreme environment formed during bubble collapse can cause a series of chemical reactions inside the bubble, and multiple products (i.e., ˙OH, H˙, O, H2, and HO2˙, etc.) are produced, which is called sonochemistry. In this study, a new model is used to predict the sonochemistry characteristics inside an oxygen bubble oscillating in water. The influences of static pressure, ultrasonic frequency, and the equilibrium radius on the temperature inside the bubble and the yields of chemical products are analyzed. The numerical calculation results are obtained during bubble oscillations under a steady state, which is different from the previous studies that focus on the sonochemical characteristics at the bubble collapse. Numerical studies show that with the change in the equilibrium radius, the maximum bubble temperature fluctuates drastically, and the maximum yields of H2 and ˙OH show a Gaussian curve trend. The cavitation activity corresponding to the equilibrium radius depends on the combination of static pressure and ultrasonic frequency.

Investigation of spatio-temporal inertial cavitation activity for optimization of needle-free ultrasound-enhanced vaccine delivery

Ultrasound-induced cavitation is a promising mechanism for pain-free delivery of vaccines without needles. However, the relationships between cavitation energy and the various bioeffects involved in transdermal vaccination, including skin permeabilization, convective drug transport, reversible and irreversible sonoporation, and immune-stimulation, are not well understood. Previous transdermal ultrasound experiments have demonstrated inhomogeneous delivery across the exposed surface, which remains poorly understood. In this work, we first seek to fully characterize and quantify spatio-temporal cavitation activity across the skin surface, to identify a local cavitation dose that is optimal for all four key bioeffects. We have designed a new in vitro experimental setup that exposes several potential skin models to 265 kHz focused ultrasound, a new generation of protein-based cavitation nuclei (pCaNs), and a fluorescently labelled vaccine analogue, while simultaneously imaging cavitation activity parallel to the skin surface by Passive Acoustic Mapping (PAM). Subsequent staining and multi-photon microscopy of the skin models allows a direct comparison between the PAM-derived spatiotemporal inertial cavitation dose and locations where particular bioeffects were maximized. We will discuss the results of this investigation, how they relate to our recent in vivo study, and whether these findings enable enhancements of the spatial homogeneity and reproducibility of needle-free ultrasound vaccination.

Towards in vivo immunotherapy using high intensity focused ultraosund

High-intensity focused ultrasound (HIFU) has been regarded as an appealing anti-cancer treatment for over a decade. HIFU indeed offers a combination of unique advantages: it is non-invasive and capable of delivering a precise and local thermal or mechanical dose without affecting the surrounding healthy tissue. HIFU is therefore already being applied as a cancer treatment in the clinics, although mostly as a thermal modality. On the other hand, immunotherapy has demonstrated remarkable promise for durable cancer treatment. However, its cost and complexity are prohibitive. Here, we evaluate (moderate) mechanical HIFU treatment and its capacity to induce immunogenic cell death with the aim to achieve immunotherapy treatment, directly in vivo. To that end, we treat a full lummox dish using an automatic scanning setup. Immunogenic cell death is monitored via distinct biomolecular markers (ATP secretion, HMGB1 secretion, calreticulin exposure). Cavitation activity is monitored via passive cavitation detection. Beyond the correspondence between acoustic cavitation and immunogenic cell death, our results also show a major influence of the cell type, namely, standard CT26 or B16F1O cells.

Active Doppler monitoring of de novo cavitation induced by a dual-mode pulsed high-intensity focused ultrasound array

Pulsed high-intensity focused ultrasound (pHIFU) is capable of inducing inertial cavitation in tissues without the need for microbubbles or other ultrasound contrast agents, thereby permeabilizing the tissue to enhance passive diffusion of systemically administered therapeutic agents. Here, we report on the use of ultrafast, synchronous power Doppler imaging to spatially map cavitation activity and resulting tissue disruption in ex vivo and invivo porcine tissues using a dual-mode imaging-therapy linear pHIFU array. The array (64 elements, aperture 51.2 mm × 14 mm, frequency 1.0MHz, 40% bandwidth) was driven by a power-enhanced Verasonics V1 system to deliver a series of 1 ms pulses at a 1% duty cycle while electronically scanning the pHIFU focus over an azimuthal range of ±1 cm. Plane wave Doppler ensembles were captured immediately after each pHIFU pulse to map the distribution and characteristics of the remnants of cavitation bubbles. The degree of resulting tissue disruption was assessed by histology and was correlated with cumulative Doppler power contours computed over the exposure region. The results show that ultrafast synchronous power Doppler is a promising approach for real-time quantitative monitoring of cavitational therapies. [Work supported by NIH R01EB023910 and T32DK007742.]

Delivery of ultrasound cavitation therapy with a modified clinical scanner

Ultrasound-induced bioeffects from stable and inertial cavitation of microbubbles in tumors have been shown to enhance systemic drug delivery. However, the high pressures and long cycle lengths needed for cavitation treatment are not available on current clinical ultrasound scanners. Here, we implement acoustic conditions (1.6 MHz, 12-500 cycles, <3 MPa, 10-200 Hz PRF) suitable for cavitation treatments (USCTx) on the S5-1 probe of a Philips EPIQ scanner. Hydrophone measurements confirmed the acoustic conditions. Passive cavitation detection (PCD) in solutions and tissue mimicking phantoms containing microbubbles demonstrated the spatial and temporal extent of the produced cavitation with 20 consecutive pulses. Inertial cavitation was observed at peak negative pressures of ∼0.5 MPa and ∼0.9 MPa in the solutions and phantoms, respectively. At low PRFs (<100 Hz), inertial cavitation was only observed within the first 5-10 pulses for both media, suggesting USCTx may generate most bioeffects in the first few pulses. The higher PRFs sustained cavitation activity for a greater duration, consistent with gas diffusion of micron size bubbles after shell disruption with the first pulse. Having implemented USCTx with a clinical scanner and confirmed the produced cavitation in vitro, we plan to evaluate this technique in an upcoming mouse study.

Real-time cavitation monitoring based on the entropic analysis of ultrasound RF signals

The violent inertial cavitation activity generated in high intensity focused ultrasound (HIFU) treatment has a risk of damaging healthy tissues around the target area, so that it is necessary to monitor the degree of cavitation during the treatment. Entropy, as a non-model-based statistical parameter, can effectively characterize the effect of cavitation on the structure of scatters within tissues. Thus, a real-time cavitation monitoring system was established based on the entropy analysis of ultrasound radio frequency (RF) signals, and the degree of cavitation was evaluated through entropy images. Based on the two-dimensional average filtering method, we achieved real-time monitoring of cavitation through the reconstruction of entropy image and the binarization of cavitation regions, breaking the inherent limitation of current systems that can only perform cavitation monitoring between HIFU pulses. The results showed that the entropy image retained more frequency components, which could determine the time and location of cavitation earlier and display cavitation areas. Moreover, as the acoustic pressure increased, the advance of cavitation indication in the entropy images became earlier. This method might provide a feasible evaluation scheme for improving real-time cavitation monitoring during HIFU treatment and was expected to become an effective reference index for imaging in HIFU surgery.

Real-Time Passive Acoustic Mapping With Enhanced Spatial Resolution in Neuronavigation-Guided Focused Ultrasound for Blood-Brain Barrier Opening.

Passive acoustic mapping (PAM) provides the spatial information of acoustic energy emitted from microbubbles during focused ultrasound (FUS), which can be used for safety and efficacy monitoring of blood-brain barrier (BBB) opening. In our previous work with a neuronavigation-guided FUS system, only part of the cavitation signal could be monitored in real time due to the computational burden although full-burst analysis is required to detect transient and stochastic cavitation activity. In addition, the spatial resolution of PAM can be limited for a small-aperture receiving array transducer. For full-burst real-time PAM with enhanced resolution, we developed a parallel processing scheme for coherence-factor-based PAM (CF-PAM) and implemented it onto the neuronavigation-guided FUS system using a co-axial phased-array imaging transducer. Simulation and in-vitro human skull studies were conducted for the performance evaluation of the proposed method in terms of spatial resolution and processing speed. We also carried out real-time cavitation mapping during BBB opening in non-human primates (NHPs). CF-PAM with the proposed processing scheme provided better resolution than that of traditional time-exposure-acoustics PAM with a higher processing speed than that of eigenspace-based robust Capon beamformer, which facilitated the full-burst PAM with the integration time of 10 ms at a rate of 2 Hz. In vivo feasibility of PAM with the co-axial imaging transducer was also demonstrated in two NHPs, showing the advantages of using real-time B-mode and full-burst PAM for accurate targeting and safe treatment monitoring. This full-burst PAM with enhanced resolution will facilitate the clinical translation of online cavitation monitoring for safe and efficient BBB opening.

The relevance of bubble dynamics in ultrasonic/sonochemical processes

Acoustic cavitation bubble dynamics has been extensively studied by physicists and mathematicians. Process intensification is primarily studied by chemical engineers. Chemists tend to focus on bubble dynamics in a multibubble field to optimize the physical and chemical forces generated during acoustic cavitation with an intention to maximise/intensify chemical processes. To achieve process intensification successfully a multidisciplinary approach is required. Our early work on multibubble cavitation unveiled various factors that contribute to process optimization. For example, while single bubble dynamics can estimate the maximum bubble temperatures, they may not be relevant to achieving higher chemical yield, which in turn depends on varus other factors such as average bubble temperatures, number of active cavitation bubbles, etc. Other factors critical for process intensification include the generation of a homogeneous cavitation field, control over mass transfer effects caused by bubble oscillations, reactor design, etc. The presentation will provide an overview on the relevance of single and multibubble bubble dynamics in ultrasonic/sonochemical processes.

Study on DeNOx of NaClO2 in simulated seawater solution enhanced by hydrodynamic cavitation

Ship exhaust causes significant air pollution, and NOx is one of the most challenging pollutants to remove. In this study, we propose a novel method for denitrification (DeNOx) using NaClO2-simulated seawater solution enhanced by hydrodynamic cavitation. We investigate the impact of initial solution pH, temperature, NaClO2 concentration, and the inlet pressure of the hydrodynamic cavitation reactor on DeNOx efficiency. The results indicate that under optimal conditions, a 100 % DeNOx efficiency can be achieved with a NaClO2 concentration of 0.1 mmol/L. Cavitation enhances mass transfer by generating microjets and increasing the gas–liquid contact area. The oxidation of NO and NO2 by hydroxyl radicals and chlorine oxygen radicals produced through cavitation could potentially enhance NOx removal efficiency. The presence of dissolved salts in simulated seawater might boost cavitation activity by reducing vapour pressure and increasing interfacial tension, leading to the more robust collapse of cavitation bubbles and thereby reinforcing cavitation effects. In addition, the multiple reactive inorganic chlorinated radicals (Cl, HClO / ClOH·-, Cl2·-) formed in simulated seawater due to the presence of Cl- might also play an essential role in DeNOx. This study demonstrated that the DeNOx by NaClO2 in simulated seawater enhanced by hydrodynamic cavitation was a promising option for NOx removal, especially for ocean-going vessels.

Prototype of a Coupling Device to Investigate Focused Ultrasound-Induced Inertial Cavitation for Drug Delivery Applications

Abstract Focused ultrasound (FUS) can be used as a drug delivery application for localized chemotherapy to treat cancer. The effect of ultrasound-induced inertial cavitation is promising to trigger drug release from nanocarriers. To investigate this effect, usually, a passive cavitation detection setup is employed. However, applying such a setup is challenging for in vivo experiments, as the test object may need to be fixed inside the water tank. Thus, we present a prototype of a coupling device that could significantly simplify experiments. Since this setup favors undesired sound wave interference and their resulting exceedance of the Mechanical Index, we additionally investigated different signal lengths. The occurrence of standing waves at a signal length of 44 cycles can both be derived from a changing cavitation activity and our calculations. The appearing interference also results in a mean increase of the cavitation activity by ≈ 5.1 %, verified by our experiments as well.

ОПРЕДЕЛЕНИЕ РЕЖИМОВ УЛЬТРАЗВУКОВОЙ КАВИТАЦИОННОЙ ОБРАБОТКИ МОТОРНОГО ТОПЛИВА

The article considers an example of ultrasonic cavitation created by a piezoelectric emitter. To identify the modes of ultrasonic cavitation treatment, the Qsonica sonicators Q-700 laboratory unit was used. The aim of the work is to determine the modes of ultrasonic treatment of motor fuel to create a cavitation region. Cavitation areas were determined by the area of destruction of aluminum foil samples, 0.008-0.009 mm thick. A sheet of aluminum foil was placed in the test medium parallel and perpendicular to the tip at different distances h, l. In order to identify the intensity of the resulting cavitation, cavitation noise was isolated from the signal of a hydrophone immersed in motor fuel at different distances from the radiator and connected to a multimeter model UT61E. The intensity of cavitation was estimated by the change in the resistance of the medium, R. The following types of motor fuel were used for processing: commercial diesel fuel, biodiesel based on ginger oil, mixed diesel fuel (containing 20% biodiesel). After the study, the foil was dried and the area of destruction was determined. It has been established that the following parameters influence the creation of cavitation – the distance from the radiating surface, intensity, amplitude and time of ultrasonic treatment of the sample.f= f (l, h, I, A, t). Four cavitation areas are defined: the area of active or optimal cavitation, the area of the beginning of cavitation, the area of incipient cavitation, the area of absence of cavitation. Depending on the amplitude and intensity, 6 operating modes are highlighted. It is established that the processing of the used motor fuel should be carried out on the 3 cavitation mode of operation (A =21-40%, I= 12.5-24.8 W / cm2) of the laboratory installation in the used technological volume or in larger volumes with reflective surfaces. It has been found that the cavitation noise in biodiesel is lower than in diesel fuel, since it is more viscous. In viscous liquids, cavitation is less developed and, consequently, the ultrasound absorption coefficient is lower for them. In this regard, it is necessary to design devices for media with a higher viscosity based on the optimal distance from the radiator to the bottom.

Sonochemical reactor characterization in the presence of cylindrical and conical reflectors

Ultrasonic systems must be able to produce an acoustic field with the highest possible energy concentration in sonochemical reactors to accomplish maximum efficacy in the sonolytic degradation of water contaminants. In the present study, the impact of cylindrical and conical stainless-steel reflectors placed on the liquid surface on the sonochemical oxidation activity of ultrasonication reactors was investigated. The amount of effective acoustic power transferred to the ultrasonicated medium without and with reflectors was measured by calorimetric characterization of the sono-reactors at diverse ultrasonication frequencies in the interval of 300–800 kHz and different electrical powers in the range of 40–120 W. Iodide dosimetry without and with reflectors at diverse ultrasonication conditions (300–800 kHz and 40–120 W) and various aqueous solution volumes in the range of 300–500 mL was used to assess the sonochemical oxidation activity, i.e., the generation of oxidative species (mainly hydroxyl radicals). Sonochemiluminescence (SCL) imaging was used to study the active acoustic cavitation bubbles distribution in the sono-reactors without and with reflectors. Significant impacts of the position and shape of the reflectors on the active acoustic cavitation bubble distribution and the sonochemical oxidation activity were observed due to remarkable modifications of the ultrasonic field by directing and focusing of the ultrasonic waves. A significant augmentation in the triiodide formation rate was obtained in the presence of the conical reflector, especially at 630 kHz and 120 W (60.5% improvement), while iodide oxidation was quenched in the presence of the cylindrical reflector at all ultrasonication frequencies and powers. The SCL images show a noteworthy modification in the ultrasonic field and the acoustic cavitation bubble population when reflectors were used. The sonochemical oxidation activity was improved by the conical reflector when placed in the Fresnel zone (near field region).