Cause Of Women Research Articles

Impact of Improvement in Walking Speed on Hospitalization and Mortality in Females with Cardiovascular Disease.

Cardiovascular disease (CVD) is the principal cause of death in women. Walking speed (WS) is strongly related with mortality and CVD. The rate of all-cause hospitalization or death was assessed in 290 female outpatients with CVD after participation in a cardiac rehabilitation/secondary prevention program (CR/SP) and associated with the WS maintained during a moderate 1 km treadmill-walk. Three-year mortality rates were 57%, 44%, and 29% for the slow (2.1 ± 0.4 km/h), moderate (3.1 ± 0.3 km/h), and fast (4.3 ± 0.6 km/h) walkers, respectively, with adjusted hazard ratios (HRs) of 0.78 (p = 0.24) and 0.55 (p = 0.03) for moderate and fast walkers compared to the slow walkers. In addition, hospitalization or death was examined four to six years after enrollment as a function of the change in the WS of 176 patients re-assessed during the third year after baseline. The rates of hospitalization or death were higher across tertiles of reduced WS, with 35%, 50%, and 53% for the high (1.5 ± 0.3 km/h), intermediate (0.7 ± 0.2 km/h), and low tertiles (0.2 ± 0.2 km/h). Adjusted HRs were 0.79 (p = 0.38) for the intermediate and 0.47 (p = 0.02) for the high tertile compared to the low improvement tertile. Improved walking speed was associated with a graded decrease in hospitalization or death from any cause in women undergoing CR/SP.

Nanoformulated Ajwa (Phoenix Dactylifera) Bioactive Compounds Improve the Safety of Doxorubicin without Compromising its Anticancer Efficacy in Breast Cancer.

One of the major causes of women’s death in the world is breast cancer. Consequently, numerous regimens for the control of this severe disease have been created. The chemotherapeutic agent doxorubicin (DOX) is frequently used to treat breast cancer, but DOX can also cause cardiotoxic effects that lead to heart failure. Therefore, many research studies have been done to find a natural product that effectively potentiates or does not interfere with DOX’s anticancer effect and protects against its cardiotoxicity. We studied the impact of combined nanoformulated Ajwa (Phoenix dactylifera) selected bioactive compounds (BAC) rutin (R) and quercetin (Q) in nude mice breast cancer xenografts on DOX-mediated anticancer efficacy. We also studied if this Ajwa BAC could safeguard against DOX-mediated cardiomyopathies by evaluating plasma cardiac troponin-I (cTn-I) levels and cardiac histopathology. Nanoformulated Ajwa BAC effectively alleviated weight loss induced by DOX in mice and significantly decreased the elevated cTn-I. Furthermore, 5 mg RQ-NPs/kg of nude mice that subcutaneously daily injected for 11 days, attenuated the histopathological alterations induced in cardiac muscles due to DOX without any interference with the anticancer effects of DOX against breast cancer.

COVID-19 will set back the cause of women’s rights in Indonesia

COVID-19 will set back the cause of women’s rights in Indonesia

Effect of Educational Guideline on Student Nurse Knowledge and Attitude Regarding Women Reproductive Rights

Abstract Background: Women reproductive rights is nursing concern which is considered vital importance and one that has wide spread implications on health, wellbeing and development of the entire population. Reproductive health problems are leading cause of women's ill health and death worldwide. Aim: Evaluate the effect of educational guideline on student nurse knowledge and attitude regarding women reproductive rights. Design: A quasi-experimental research design. Sample: 83 female nursing students in the third and fourth academic year, purposive sample. Tools of data collection: Structured Interviewing, and women reproductive rights attitude assessment scale Results: A statistically significant improvement was observed among studied sample knowledge pre intervention compared to post intervention, significant improvement was observed among studied sample attitude pre intervention compared to post intervention, and the majority was satisfied with application of educational sessions regarding women rights. The study conclusion that there were statistically significant changes immediately following the introduction of the program and throughout the follow-up process regarding the analyzed sample awareness and perceptions relating to reproductive rights of women. Recommendation: the present recommended an educational guideline was suggested to be replicated in another setting and on another sampling.

Hysterectomy and Oophorectomy in Reproductive Age: A Cross-Sectional Study from a Tertiary Care Hospital.

IntroductionHysterectomy is a common surgical procedure in women, and oophorectomy may also be performed with the hysterectomy. The objective of this study was to identify clinical indications and pathological findings in hysterectomies, performed for gynecological causes, in women of reproductive age (15-49 years) and to determine if oophorectomy or ovarian conservation was performed with the hysterectomy as well as the pathological findings in the ovaries.MethodsThis cross-sectional study was conducted in the department of Pathology at Dow Medical College in Karachi, Pakistan, from September 2017 to December 2018. Data were recorded from the pathology reports of hysterectomy specimens received in the department. Data of hysterectomies performed for gynecological causes in women of reproductive age group were selected and analyzed, using Microsoft Excel (Microsoft, Redmond, Washington) and SPSS version 20 (IBM Corp., Armonk, New York). Data of women more than 49 years and obstetric hysterectomies were excluded.ResultsThree hundred sixty-one hysterectomies were received; 157 of which were hysterectomies performed in women of reproductive age for gynecological reasons. The mean age of the women was 40.37 (± 5.47) years. Abnormal uterine bleeding was the most frequent clinical indication for hysterectomy in 81 (51.59%) women, followed by uterine prolapse in 29 (18.47%) and leiomyoma in 22 (14.01%). Common pathologies in the endometrium were endometritis in 14 (8.92%) and endometrial polyp in nine (5.73%). In the myometrium, leiomyoma was reported in 52 (33.12%) cases, adenomyosis in 37 (23.57%), and both leiomyoma and adenomyosis in 37 (23.57%) women. Uterine prolapse was histologically identified in 38 (24.20%) women. Oophorectomy was performed on 107 (68.15%) women, and out of these, 83 (77.59%) women's ovaries showed either normal histology or functional cysts. Ovarian pathologies reported were endometriosis, serous cystadenomas and oophoritis in five patients each (4.81%), ovarian serous carcinoma in three (2.88%), and mucinous carcinoma in one (0.96%) patient.ConclusionAbnormal uterine bleeding was the most common clinical indication for hysterectomy in women of reproductive age. The common pathologies in the hysterectomies were endometritis, endometrial polyp, leiomyoma, adenomyosis, and uterine prolapse. Most of the ovaries removed with the hysterectomy did not show any significant pathology, therefore, further studies in this direction are recommended for confirmation of this finding. Ovarian conservation may be considered in women undergoing hysterectomy for abnormal uterine bleeding or other uterine causes and with no radiological or surgical indication for oophorectomy.

Chlorpyrifos effects on integrin alpha v and beta 3 in implantation window phase.

Chlorpyrifos (CPF), as a worldwide pesticide, can effect on the integrins αv and β3 which play a main role in the implantation window. Therefore, the aim of this study was to consider CPF effects on integrin alpha v and beta 3 in implantation window phase. Thirty female NMRI mice were separated into groups of CPF, sham, and control. After 6weeks, each group was mated, and on the 5th day of gestation, all mice were euthanized. Estradiol and progesterone levels were detected by the enzyme-linked immunosorbent assay (ELISA) test; two subunits of integrins (αv and β3) genes and proteins of endometrium were analyzed by real-time polymerase chain reaction (RT-PCR) and immunohistochemistry method, respectively. Fibrosis of the liver which evaluated by Masson's trichrome stain was increased in the CPF group compared with the others. But estradiol and progesterone levels were significantly decreased in CPF groups. Based on the findings, the proportion of genes' expressions of integrin subunits declined by the effect of CPF, while there was not any notable consequence on mice in the sham group. Alpha v and beta 3 integrin proteins expressed in all groups, but the concentration of these proteins in CPF groups was lower than in other groups. This study has shown that the decline of estradiol and progesterone downregulates the expression of αv and β3 integrins which were influenced by CPF exposure. Changing these patterns of proteins could have numerous influences on unsuccessful implantation. Therefore, this experimental study recommends that inclusive consideration of the effects of insecticides may be crucial to women's unrecognized cause of infertility.

The study on the effect of depression on breast cancer incidence through IDO/kynurenine pathway.

e13569 Background: Psychosocial factors have been considered as the most common causes for women with breast cancer. However, it remains unclear whether mental stress can influence cancer incidence and progression. This study aims to investigate the relationship between them and the potential molecular mechanism. Methods: Depression model was established by restricting MMTV-PyMT mice in a 50ml-fixator for 4 h per day for 21 consecutive days. Behavioral tests including light-dark box test, open-field test and force swimming test were performed. Then blood, brain and mammary samples were collected at the indicated time points. ELISA was used to detect the concentration of neurotransmitters serotonin, epinephrine and norepinephrine and inflammatory factors IL-6, TNF-a and IL-1β in brain tissue and serum. Real-time quantitative qPCR and western blot were used to detect indoleamine 2, 3-dioxygenase (IDO) expression. The level of tryptophan was measured by high performance liquid chromatography(HPLC). Flow cytometry was used to evaluate the exhaustion of CD8+ T cells. Besides, the correlation between IDO expression detected by immunohistochemistry and the severity of mammary tumors was analyzed in the tumor specimens. Results: We observed that chronic stress caused depression-like behaviors, abnormal secretion of neurotransmitters serotonin, epinephrine and norepinephrine and promoted the development of breast cancer in MMTV-PyMT mice. Depression elevated the secretion of inflammatory factors IL-6, TNF-a and IL-1β in brain tissue and serum, which upregulated the expression of IDO and decreased the level of tryptophan in mice. Furthermore, T cells are sensitive to low tryptophan concentration, so elevated IDO expression suppressed and exhausted CD8+ T cells, ultimately promoting cancer incidence. Administration of xiaoyao pill (a well-known Chinese herbal formula for treating depression) or IDO inhibitor reversed the depression-like behaviors in mice and slowed the development of breast cancer. At the same time, the analysis of clinical samples showed that depression identified by Hamilton Depression Scale(HAMD) and IDO expression in mammary tumor tissues were positively correlated with the severity of mammary tumors. Conclusions: Altogether, our results suggest that depression can promote tumor immune privilege and cancer occurrence through inducing upregulated IDO expression.

Comparing the quality of life of women suffering from breast cancer receiving palliative care and ordinary care

Introduction: Breast cancer is the most prevalent cancer and leading cause of women’s mortality due to malignancy. Treatment increases the survival however it is associated with poor quality of life and bringing the patients toward palliative care. Objectives: This study was conducted to compare the quality of life in patients with breast cancer receiving palliative care and ordinary care. Patients and Methods: This descriptive-analytical study was carried out in Tehran hospitals (February to August 2017). The sample consisted of 220 breast cancer women who had completed the therapy four weeks prior to the study. The European Organization for Research and Treatment of Cancer quality of life Questionnaire (EORTC QLQ-C30), its supplementary breast cancer questionnaire (QLQ-BR23) and International Physical Activity Questionnaire (IPAQ) were applied to assess the quality of life of patients who received palliative care (n=110) and ordinary care (n=110). Descriptive and inferential statistics (t test and Mann-Whitney U test) were applied to analyze the data through SPSS 21. Results: The palliative care group demonstrated higher quality of life compared to the ordinary care group. Scores in functioning and global health were higher in the palliative care group than the ordinary care group. The palliative care group also had higher scores in sexual functioning, body image, future perspective, physical activity and lower scores in symptom scales, arm symptoms and hair loss than the ordinary care group (P<0.001). Conclusion: Palliative care provides more desired quality of life than ordinary care in breast cancer women and can be effective to improve the quality of life in these patients.

Menjanda sebagai Model Resiliensi Perempuan

Women in rural Madura prefer to live alone as a widow after being left by husbands (divorced/deceased). This phenomenon is better known as a single mother. The single mother women perform dual roles in the family, namely public roles and domestic roles. This research focuses on the causes of women who prefer to be single mothers as well as their strategies in maintaining resilience in the family. The case study approach and qualitative methods are used to understand the phenomenon. The data show that several factors influence women in Ponteh village to live longer as single mothers than men after getting divorced. Firstly, wanting to raise their children, secondly, for women, divorce is a traumatic event, third, understanding of Islamic thought, fourth, social prestige. The resilience of single mothers is indicated by their multiple roles as women. Women are more active in productive activities as well as reproductive or domestic activities. The contribution of this article is to explain more about the single mother phenomenon in rural Madura.

Utilization of Flavonoid Compounds as HER2 Tyrosine Kinase Inhibitor in Breast Cancer Using Fragment-Based Drug Design

Breast cancer has become one of the leading cause of women’s death around the world. Breast cancer can be caused by genetic or environmental factors. Human epidermal growth factor receptor 2 (HER2) is one of the main causes of breast cancer. The HER2 tyrosine kinase plays a significant role in the dimerization reaction which causes auto-phosphorylation of tyrosine residues in the cytoplasmic domain that triggers growth of the cancer cells. Inhibition of HER2 protein activity can be a potential alternative for breast cancer treatment. Flavonoids have become an important scaffold in medicinal chemistry due to its bioactivity and availability. Therefore, flavonoids were used as the database on this in silico research. Fragment-based drug design was applied to determine novel drug candidates. Three potential candidates were obtained in this research. VC-962 was selected as the best inhibitor candidates for HER2 tyrosine kinase.

Negotiated Agency amidst Overlapping Vulnerabilities of Women Migrant Workers in South Asia

Marriage, family reunification, forced labour and trafficking are some of the most widely attributed causes of women’s migration within South Asia. This paper contributes to a small but growing literature about women’s migration within South Asia for employment amidst social, cultural and policy level barriers that hinder women’s mobility choices. It examines the experiences of 45 migrant women from economically poorer backgrounds comprising both cross-border, undocumented migrants from Nepal and Bangladesh and internal migrants from India working in informal jobs within India. This paper also explores similarities and differences between migration and labour market experiences of women migrants in South Asia showing how migration for employment can contribute towards agency formation but at the same time increase vulnerability by bringing about a reduction in well-being, security and dignity in the absence of secure policies that address challenges of women migrants in the region.

Data preprocessing in knowledge discovery in breast cancer: systematic mapping study

ABSTRACT Data Mining (DM) is a set of techniques that allow to analyse data from different perspectives and summarising it into useful information. Data mining has been increasingly used in medicine, especially in oncology. Data preprocessing is the most important step of knowledge extraction process and allows to improve the performance of the DM models. Breast cancer (BC) becomes the most common cancer among females worldwide and the leading cause of women's death. This paper aims to perform a systematic mapping study to analyse and synthesise studies on the application of preprocessing techniques for a DM task in breast cancer.Therefore, 66 relevant articles published between 2000 and October 2018 were selected and analysed according to five criteria: year/channel of publication, research type, medical task, empirical type and preprocessing task. The results show that Conferences and journals are the most targeted publication sources, researchers were more interested in applying preprocessing techniques for the diagnosis of BC, historical-based evaluation was the most used empirical type in the evaluation of preprocessing techniques in BC, and data reduction was the most investigated task of preprocessing in BC. However, A low number of papers discussed treatment which encourages researchers to devote more efforts to this task.

Social Support and Breast Cancer Recurrence: Is there any Association?

Background: Breast cancer is the most prominent cause of women's mortality due to cancer and is one of the most serious and commonly diagnosed cancers among Iranian women. Also, social support plays a vital role in breast cancer patients' lives and their diagnosis and treatment processes. This study aimed to determine the associations between social support status and the recurrence of breast cancer in women breast cancer referred to the Breast Diseases Research Center in Motahari Clinic in Shiraz, Iran in 2018. Methods: This was an applied and descriptive-analytic study on women with breast cancer referred to the Breast Diseases Research Center in Motahari Clinic in Shiraz, Iran in 2018. A sample of 221 patients in two groups of 117 non-recurrence patients and 44 patients with recurrence and metastasis were selected randomly. A localized standard questionnaire was used to collect the required data. The collected data were analyzed using SPSS 24.0. Results: Based on the results, there were significant differences between the two studied groups of patients with and without recurrence in terms of the means of social support and all of its dimensions (P-value<0.05); the means of social support and all of its dimensions in the group of patients without recurrence were higher than those in those with recurrence. Also, 88.6% of patients in the group without recurrence received high social support, while in the group of patients with recurrence, only 11.4% of them received high social support. Conclusion: The results showed that the breast cancer patients studied without recurrence had higher social support. Therefore, to improve the studied patients' health, we recommend providing the patients with a safe and secure environment, giving accurate and complete responses to the patients' questions, providing continuous psychological counseling, etc.

Intertextuality, Multiple Voices, and Ambiguity in P.Sivakami’s Author’s Notes and Nawal El Saadawi’s The Fall of the Imam

P. Sivakami and Nawal El Saadawiare bureaucrats-turned writers who espouse the cause of women who are victims of patriarchy and display remarkable agency and purpose in subverting the systems of oppression prevalent in their respective local settings. The protagonists of the novels selected for the study ultimately succumb to the system, but they do not give up without a fight. The novels chosen for analysis in this paper are P. Sivakami’s Author’s Notes and Nawal El Saadawi’s The Fall of the Imam. This paper analyses the novels from a postmodern perspective and attempts to bring out the elements of intertextuality, multiple voices and ambiguity in these two novels.

ANÁLISIS CRÍTICO COMPARATIVO DE LA APLICACIÓN DE LAS LEYES DE BANGKOK EN EL RECURSO HUMANO DEL CENTRO FEMENINO DE REHABILITACION DOÑA CECILIA ORILLAC DE CHIARI, DESDE UNA PERSPECTIVA INTERNA. Un Enfoque Histórico, Geográfico Y Social

A principios de los años noventa, se examinó la mayoría de los encierros femeninos, de las distintas penitenciarías y centros de readaptación social de América Latina. Como resultados destacados, se subraya la falta de centros exclusivos para mujeres, a excepción de unos pocos llamados de “readaptación social”, lo que crea muchas desventajas para ellas, porque siempre se priorizan las demandas, los espacios, los servicios y la atención de los hombres, y las de las mujeres, están postergadas indefinidamente. Otros estudios en esta región, demuestran que el número de mujeres ha crecido tres veces más que el de los hombres, en el período 1994-2004. Asimismo, se repiten las historias de mujeres pobres, con hijos e hijas y mayormente presas contra la salud y por delitos de drogas, que cada vez aumenta.
 Un estudio realizado en México da cuenta de una realidad particular, afirmando que la mayoría de las mujeres que purgan condenas en las cárceles no deberían estar allí, pues se trata de personas no peligrosas que generalmente fueron arrastradas por sus parejas a cometer los ilícitos. En Latinoamérica los delitos relacionados con las drogas han ido incrementando hasta constituirse en la primera causa por la que se encuentran en prisión las mujeres, a diferencia de lo que ocurre entre los varones. Esta investigación, al igual que diversos autores, coincide en que la conducta delictiva femenina es diferente de la masculina: las mujeres que infringen principalmente la ley de drogas, son menos violentas, menos reincidentes e inician su carrera delictiva de forma tardía. Sin embargo, los autores consultados aseguran que la mujer ingresa al sistema penitenciario frecuente por el tráfico de estupefacientes, cifras que van en aumento, lo cual se observa en diferentes países: México, Argentina, Panamá y Estados Unidos, entre otros.

Beyond Safety: Refusing Colonial Violence Through Indigenous Feminist Planning

Settler colonial violence targets Indigenous women in specific ways. While urban planning has attended to issues of women’s safety, the physical dimensions of safety tend to be emphasized over the social and political causes of women’s vulnerability to violence. In this paper, we trace the relationship between settler colonialism and violence against Indigenous women. Drawing on examples from community activism and organizing, we consider how Indigenous feminism might be applied to planning and point toward approaches to planning that do not replicate settler colonial violence.

Factors related to infertility in Brazil and their relationship with success rates after assisted reproduction treatment: an integrative review

This integrative review evaluated the most commonly diagnosed causes of infertility in men and women in Brazil, as well as the medically assisted reproduction technologies regularly employed in these cases. We searched in four electronic databases (PubMed, including Medline; Scopus; Web of Science and LILACS), and two grey literature (Google Scholar and OpenGrey), guided by the focused question: "What are the main factors responsible for male and female infertility in Brazil, and what are its relationships with success rates after assisted reproduction treatment?". We included interventional or observational studies, without limitation by language or year of publication. Our searches in the electronic indexers recovered 1,119 articles, and after analyzing the inclusion and exclusion criteria, 27 articles composed the body of analysis for this review. We grouped the studies into four themes: factors responsible for male and female infertility, assisted reproductive technologies (ART) used in the infertility treatment, assisted reproduction procedures, and clinical predictors of success rates in ART. Despite the scarcity of studies analyzing the association between infertility and assisted reproductive technologies in Brazil, it was possible to infer that the most prevalent infertility cause in women was endometriosis, while in men it was azoospermia. The most widely assisted reproductive technology applied in the country is the intracytoplasmic injection of spermatozoa (ICSI), ensuring better success rates in the treatment of infertility for men and women.

Acute ischemic stroke profile in women attending Tanta University Hospital

Background Stroke has a higher negative effect on women than men. In developed countries, stroke has regressed to be the fifth cause of death in men but still the third cause in women. It is suggested that there will be an increase of stroke burden in women in the future. Aim The aim was to study clinical presentation, risk factors, and short-term outcome of acute ischemic stroke in women admitted to Tanta University hospitals. Patients and methods A cross-sectional study was conducted that included 386 patients admitted to the Department of Neuropsychiatry and Centre of Psychiatry, Neurology, and Neurosurgery at Tanta University Hospitals with first-ever ischemic stroke. We assessed stroke severity by National Institutes of Health Stroke Scale. Stroke type and etiology were assessed by Oxford Shire Community Stroke Project classification and Trial of org 10172 in acute stroke treatment classification. The authors assessed outcome on discharge by modified Rankin scale. Results Regarding type of stroke, cerebral venous thrombosis was more in females, with significant difference; arterial ischemic stroke in females was less than in males, with significant difference; and total anterior in females was more than in males, with significant difference. Predictors of unfavorable outcome in females were age above 60 years old, being unmarried, hypertension, diabetes, and cardiac disease. Conclusion Hypertension, mean duration of diabetes, and BMI increase the risk of ischemic stroke in women. Age above 60 years old, currently unmarried, hypertension, cardiac diseases, and diabetes mellitus increase unfavorable outcome in women.

Liberal Feminism Impact on Moroccan Educated Women: Faculty of Letters and Human Sciences, FLDM, as a Field Study

AbstractThe present study is an attempt to investigate students’ attitudes towards the social status of Moroccan women and the variables that may influence the cause of women’s liberation. These variables may include feminism, female activism and international human rights on the one hand. On the other hand, factors such as religion, patriarchy and marriage legislation could stand against the cause of female emancipation. The paper uses a theoretical and practical part. The review of literature is broad and inclusive that it trespasses the national intellectual framework on the issue of women’s liberation to referring to western major feministic movements for women’s emancipation worldwide such as liberal feminism. The field work is conducted through distributing a representative number of questionnaires, 350 questionnaires. Briefly, the findings proved that the majority of respondents, 55% hold the view that religion stands as a primary factor behind conservative gender perception, whereas 49% of the respondents believe that education is the factor behind such perceptions. Furthermore, 40% believed that the patriarchal system is the element behind traditional treatment of gender. Concerning marriage legislation, 55% agree with the reforms in Al Mudawana in 2004. For female activism, 72% believe that women largely contributed in bringing about the changes in the Al Mudawana reforms of 2004. This helped to generate an increasing female participation in politics as proved by 58% of the respondents. Finally, 65% hold the view that women’s social status nowadays is semi-liberal and improving.

Chrystal Macmillan, Scottish campaigner for women’s equality through law reform

ABSTRACT This article will explore the work of Chrystal Macmillan, who used her knowledge of the law to further the cause of women’s equality through her committee work with several voluntary organisations, and her presentations to the British Government, the League of Nations, and the International Labour Office. Using archival material, both from committee minutes and family anecdotes, we will show the substantial amount of voluntary work undertaken by Chrystal Macmillan both before and after she became a practising lawyer in 1924. The article will also try to capture something of the woman’s character through the comments of her friends and colleagues.