Causes Of Different Types Research Articles

Does every public open space (POS) contribute to sustainable city development? An assessment of inefficient POS in Beijing

Public open space (POS) plays a crucial role in influencing the urban environment, ecology, public health, and economic vitality. However, not every POS is being efficiently utilized, while the inefficient POSs occupy large areas and can negatively affect socio-economic development, thus posing a threat to sustainable city development. Existing studies evaluate POSs solely based on benefit outcomes, but ignore POS functional types and contextual environments. To address this issue, a categorized, integrated, and relative evaluation method, i.e., utilization efficiency (UE), is proposed to identify inefficient POSs, where essentially measures the ratio from benefit outcome to resource occupation of each POS. We firstly classify POSs into five types by considering their core functions, then measure their UEs to extract efficient and inefficient POS, and finally visualize key causes of different types of POS. Our results reveal 3,138 inefficient out of 10,943 POSs in Beijing, and show the inefficient POSs that are concentrated in the southern Beijing and northern regions between the 5th and 6th ring roads, mainly affected by local population density and environmental resource. Drawing on the features of inefficient POSs, it is suggested to increase small green spaces and sky gardens in the downtown areas, improve service facilities and basic tourism infrastructure in the suburbs. Accordingly, this study firstly incorporates POS functional types and resource occupation into the utilization efficiency evaluation, providing spatial optimization recommendations of POSs to facilitate sustainable city development.

Improving our understanding of predictive bias in testing.

Predictive bias (i.e., differential prediction) means that regression equations predicting performance differ across groups based on protected status (e.g., ethnicity, sexual orientation, sexual identity, pregnancy, disability, and religion). Thus, making prescreening, admissions, and selection decisions when predictive bias exists violates principles of fairness based on equal treatment and opportunity. First, we conducted a two-part study showing that different types of predictive bias exist. Specifically, we conducted a Monte Carlo simulation showing that out-of-sample predictions provide a more precise understanding of the nature of predictive bias-whether it is based on intercept and/or slope differences across groups. Then, we conducted a college admissions study based on 29,734 Black and 304,372 White students, and 35,681 Latinx and 308,818 White students and provided evidence about the existence of both intercept- and slope-based predictive bias. Third, we discuss the nature and different types of predictive bias and offer analytical work to explain why each type exists, thereby providing insights into the causes of different types of predictive bias. We also map the statistical causes of predictive bias onto the existing literature on likely underlying psychological and contextual mechanisms. Overall, we hope our article will help reorient future predictive bias research from whether it exists to the why of different types of predictive bias. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Hysteresis and Its Correlation to Ionic Defects in Perovskite Solar Cells.

Ion migration has been reported to be one of the main reasons for hysteresis in the current-voltage (J-V) characteristics of perovskite solar cells. We investigate the interplay between ionic conduction and hysteresis types by studying Cs0.05(FA0.83MA0.17)0.95Pb(I0.9Br0.1)3 triple-cation perovskite solar cells through a combination of impedance spectroscopy (IS) and sweep-rate-dependent J-V curves. By comparing polycrystalline devices to single-crystal MAPbI3 devices, we separate two defects, β and γ, both originating from long-range ionic conduction in the bulk. Defect β is associated with a dielectric relaxation, while the migration of γ is influenced by the perovskite/hole transport layer interface. These conduction types are the causes of different types of hysteresis in J-V curves. The accumulation of ionic defects at the transport layer is the dominant cause for observing tunnel-diode-like characteristics in the J-V curves. By comparing devices with interface modifications at the electron and hole transport layers, we discuss the species and polarity of involved defects.

Landslide Mapping and Causes of Landslides in the China–Nepal Transportation Corridor Based on Remote Sensing Technology

The China–Nepal Transportation Corridor is vital to the country’s efforts to build a land trade route in South Asia and promote the Ring-Himalayan Economic Cooperation Belt. Due to the complex geological structure and topographical environment of the Qinghai–Tibet Plateau, coupled with the impact of climate change, the frequent occurrence of geological disasters has increased the operational difficulty of the China–Nepal Highway and the construction difficulty of the China–Nepal Railway. However, to date, there has been no systematic study of the spatial distribution of landslides along the entire route within the area, the factors influencing landslides at different scales, or the causes of landslides under different topographic backgrounds. There is an even greater lack of research on areas threatened by potential landslides. This study comprehensively applies remote sensing, mathematical statistics, and machine learning methods to map landslides along the China–Nepal transportation corridor, explore the influencing factors and causes of different types of landslides, and investigate the distribution characteristics of potential landslides. A total of 609 historic landslides have been interpreted in the study area and were found to be distributed along faults and locally concentrated. The strata from which landslides develop are relatively weak and are mainly distributed within 2 km of a fault with a slope between 20° and 30°. The direction of slope for the majority of landslides is south to south-west, and their elevation is between 4000 and 5000 m. In addition, we discovered a power law relationship between landslide area and volume (VL = 2.722 × AL1.134) and determined that there were 47 super-large landslides, 213 large landslides, and 349 small and medium-sized landslides in the area, respectively. Slope is the most significant influencing factor for the development of landslides in the area. Apart from slope, faults and strata significantly influence the development of large and medium-small landslides, respectively. We have identified 223 potential landslides in the region, 15 of which directly threaten major transport routes, mainly in the Renbu Gorge section of the China–Nepal Highway and the proposed China–Nepal Railway section from Peikucuo to Gyirong County. In addition, we also discussed the causes of landslides within three geomorphic units in the region. First, the combined effects of faulting, elevation, and relatively weak strata contribute to the development of super-large and large landslides in the Gyirong basin and gorge. Second, the relatively weak strata and the cumulative damaging effects of earthquakes promote the development of small and medium-sized landslides in the Xainza-Dinggye rift basin. Third, under the combined effect of the hanging wall effect of thrust faults and the relatively weak material composition, landslides of various types have developed in the Nagarzê mountain. It is worth noting that potential landslides have developed in all three geomorphic units mentioned above. This study provides data and theory to assist in the accurate mitigation and control of landslide hazards in the corridor.

Assessment of the respiratory predicament of bus drivers in different environmental conditions

Abstract: BACKGROUND: Bus drivers work in different environmental conditions. Pollution is one of the main burdens of their day-to-day work. Traffic flow is the likely to significantly increase emissions of different types of pollutants such as carbon monoxide, particulate matter, oxides of nitrogen, and hydrocarbons. Drivers suffer from different types of respiratory problems due to exposure to these pollutants. Studies on bus drivers are rare, and reports are scanty. METHODS: Thus, it was necessary to study respiratory functions and environmental factors in bus drivers of West Bengal. According to the locations of work, i.e. rural and urban, 254 subjects or bus drivers were involved in this study. They were alienated into two groups: rural (n = 108) and urban (n = 146). The physical parameters of the subjects were measured. European Community Respiratory Health Survey-II questionnaire was administered to know their different respiratory responses. A lung function test was performed for all the subjects. Sputum cell was counted from the induced sputum of the subjects. RESULTS: It was found that symptoms such as cough, wheezing, and phlegm were three times higher in Group 2 compared to Group 1. Spirometric findings showed that slow vital capacity (SVC), forced vital capacity, and forced expiratory volume in the 1st s (FEV1) were significantly lower among the urban or Group 2 bus drivers. It was also detected that the mean value of SVC and FEV1 were significantly lower with the smoking habit. Sputum cells study showed that significant decrease in the mean value of the total count of the urban group. However, the mean value of neutrophil count was significantly increased in urban drivers’ sputum. CONCLUSION: From this overall study, it may be determined that the drivers of both rural and urban vicinity were prone to respiratory illness due to their regular dusty working environment. Regular exposure to this environment was the potent cause of different types of respiratory illness.

A review of Kesha as diagnostic and prognostic tool in Ayurveda

Hair is one of the essential characteristic features which not only adds beauty to the person but also helps maintain normal physiological functions, especially by excreting sweat through the Lomakupa, which is considered one of the roots of Swedavaha Strotas. It also helps in thermoregulation, protection etc. It is Pitruja Bhava and is the Mala of Asthidhatu. Depending upon the Hair conditions, one can assess some of the underlying pathological status of the body. Aims & Objectives: Review the literature concerned with Prakruta and Vikruta Lakshnas of hairs in Ayurvedic classical texts for diagnosis and prognosis of the disease. Material and Methods: Material related to Hair has been collected from Charaka Samhita, Sushruta Samhita, Astanga Samgraha, and Ashtanga Hridaya along with respective commentaries available and data associated with a topic general at different journals and books. Observations: As Kesha is one of the factors which build up a person's personality, Ayurvedic classics state the advantages of hair maintenance. In the present era, changes in lifestyle, food habits, excess use of shampoos, and hair dyes, lack of oil massage to Hair, pollution, stress and strain etc., may be the cause of different types of hair problems like Khalitya (Alopecia totalis), Palitya (premature greying of Hair) etc. Therefore a proper understanding of Prakruta Lakshanas of Kesha will help in understanding the Vaikrutha Avastha which will thus ease the line of treatment. Results: Thus, Kesha and Loma play an essential role in diagnosing the Prakruta and Vaikrutha Lakshana and help in the prognosis of the disease.

From “What Works” to “Why it Works” – From a Humean to an Aristotelian Understanding of Causality

Purpose: Authors of this theoretical article are questioning Hume's view on causality by arguing for Aristotle’s pluralistic view as an alternative strategy for social work research and practice. Methods: Aristotle's notion of causality is applied to discuss its relevance, and then tested on a real case, thereby illustrating how it can contribute to explain why something works. Results: Different types of causes can reveal characteristics that are preconditional for professional's and service user's mutual roles in enhancing outcomes. They can further reveal the architecture of the intervention; the underlying processes for actions to reach a desired goal. Discussion: To deliver knowledge of relevance in social work, one needs to explain the results of an intervention through causal analysis as well as understanding the content and processes of it. Aristotle's forms of causality make it possible to take the contextual historicism of social phenomenon into consideration and give knowledge beyond effects.

Data mining of the essential causes of different types of fatal construction accidents

Accident analysis is used to discover the causes of workplace injuries and devise methods for preventing them in the future. There has been little discussion in the previous studies of the specific elements contributing to deadly construction accidents. In contrast to previous studies, this study focuses on the causes of fatal construction accidents based on management factors, unsafe site conditions, and workers' unsafe actions. The association rule mining technique identifies the hidden patterns or knowledge between the root causes of fatal construction accidents, and one hundred meaningful association rules were extracted from the two hundred and fifty-three rules generated. It was discovered that many fatal construction accidents were caused by management factors, unsafe site circumstances, and risky worker behaviors. These analyses can be used to demonstrate plausible cause-and-effect correlations, assisting in building a safer working environment in the construction sector. The study findings can be used more efficiently to design effective inspection procedures and occupational safety initiatives. Finally, the proposed method should be tested in a broader range of construction situations and scenarios to ensure that it is as accurate as possible.

Aetiology and Pattern of Presentation of Upper Gastrointestinal Tract Ulcers among Patients Attending the Gastroenterology Department of BSMMU-A Tertiary Level Hospital

Background: Upper gastrointestinal endoscopy is the most common procedure performed in Gastroenterology department for numerous indications and ulceration of the upper GI tract is one of the major pathological findings during endoscopy. Early diagnosis of upper GI ulcers with definite cause is the mainstay of therapy for patient’s cure and prevention of complications. Different clinical features are observed in different types of ulcer. Objective: The objective of this study is to find out the causes of different types of ulceration in the upper gastrointestinal tract along with their clinical presentation. Methods: This cross-sectional study was conducted in the Department of Gastroenterology, BSMMU, Dhaka, Bangladesh during the period of July 2016 to April 2017. Patients referred for upper GI endoscopy for different indications were primarily selected. Consecutive 220 patients having ulcers anywhere in the upper GIT were finally included in the study. Ulcer diseases were diagnosed through analysis of morphology of the ulcers, histopathology of biopsy materials, relevant clinical history and further investigations if required. All the findings were documented in predesigned data collection sheet. Any association between various types of ulcers with age, gender, BMI, lifestyle, location of ulcer, different signs and symptoms was assessed. Results: Out of 220 patients duodenal ulcer was found in 45.9%, gastric ulcer in 30.0%, oesophageal ulcer in 7.7%, ulceration at multiple sites in 13.6%, and stomal ulcer in 2.7% cases. Among the aetiologies H. pylori infection (62.8%), NSAIDs (14.6%) and malignant ulcers (9.1%) were found in majority of cases. Less common causes were tubercular ulcer, lymphoma, GIST, Crohn’s disease and caustic injury. Aetiology could not be identified in 6.8% cases. Among various presenting complaints epigastric pain, early satiety, anorexia, vomiting and GI bleeding were the symptoms that differ significantly in patients with ulcers ...........

The Epigenetic Modification of SLC5A8 in Papillary Thyroid Carcinoma and its Effects on Clinic-Pathological Features.

Background:Epigenetic alterations such as DNA methylation are known as the main cause of different types of cancers through inactivation of tumor suppressor genes, especially thyroid cancer. Identification of novel and effective markers are important in diagnosis and prevention of thyroid cancer. In the present study, the expression and methylation of Solute carrier family 5 member 8 (SLC5A8) in Papillary Thyroid Carcinoma (PTC) in comparison to multinodular goiter (MNG) have been studied.Methods:Overall, 41 patients with PTC and 36 patients affected by MNG were recruited from four hospitals in Tehran and Qazvin, Iran in 2018. Thyroid tissues were obtained during thyroidectomy. RNA and DNA were extracted from thyroid tissues. Quantitative RT-PCR assay was performed for determining the mRNA level of SLC5A8 while Methylation-Sensitive High-Resolution Methylation was applied for assessing the methylation status.Results:Methylation status of three regions composed of 52 CpG islands in the promoter of SLC5A8 gene was studied by HRM assay. SLC5A8 level in PTC tissues was significantly downregulated in average 0.4 fold in comparison with MNG tissues (P=0.05). The aberrant methylation of SLC5A8 (b) region was remarkably different in PTC and MNG cases. The promoter methylation of SLC5A8 (c) was significantly related to BRAF mutations and vascular invasion in PTC patients.Conclusion:The aberrant promoter hyper methylation of SLC5A8 was related to aggressive PTC. Therefore, there is some evidence to support the hypothesis that SLC5A8 could be a paly important role in the development of PTC.

Eye movement analysis in simple visual tasks

The small eye movements in the process of fixation on an image element give us knowledge about the human visual information perception. An indepth analysis of these movements can reveal the influence of personality, mood and mental state of the examined subject on the process of perception. The modern eye tracking technology provides us with the necessary technical means to study these movements. Nevertheless, still a lot of problems remains open. In the present paper two approaches for noise cancellation in the eye-tracker signal and two approaches for microsaccade detection are proposed. The analysis of the obtained results can be a good starting point for interpretation by neurobiologists about the causes of different types of movement and their dependence on the individuality of the observed person and the specific mental and physical condition.

Glycine/glycine N-methyltransferase/sarcosine axis mediates benzene-induced hematotoxicity

Benzene, an important and widely used industrial chemical, is the cause of different types of blood disorders. However, the mechanisms of benzene-induced hematotoxicity are still unclear. This study aimed to explore the effects of benzene on metabolism, especially in amino acid metabolism, in human peripheral blood B lymphocyte cells (AHH-1 cells) treated with 1,4-benzoquinone (1,4-BQ) and in benzene-exposed population based on the un-targeted and targeted metabolomics platforms. The results showed that 1,4-BQ disturbed the metabolic activity, such as arginine biosynthesis, citrate cycle, glycine, serine, and threonine metabolism pathways, and significantly upregulated the ratio of sarcosine/glycine in vitro. Meanwhile, the targeted metabolomics further showed that the ratio of sarcosine/glycine was also increased in the benzene exposure population. Notably, the expression of glycine N-methyltransferase (GNMT), an enzyme catalyzing the transformation of glycine to sarcosine, was upregulated both in 1,4-BQ treated AHH-1 cells and benzene-exposed workers. These results imply that the glycine/GNMT/sarcosine axis was involved in benzene-induced hematotoxicity. Such evidence will help to develop a better understanding of the underlying mechanism of benzene-induced hematotoxicity at the level of amino acid metabolism.

Genetic basis of hereditary hypophosphataemic rickets and phenotype presentation in children and adults.

Hypophosphataemic rickets (HR) is a genetic disorder causing defects in the renal handling of phosphorus, resulting in rickets. HR can be classified into two groups. First- those with excess fibroblast growth factor 23(FGF23) levels, which are due to gene mutations in extrarenal factors and include X-linked dominant hypophosphataemic rickets (XLHR), autosomal dominant hypophosphataemic rickets (ADHR), autosomal recessive hypophosphataemic rickets (ARHR), and hypophosphataemic rickets with hyperparathyroidism. Second- those with normal or low FGF23, which are caused by gene mutations in renal tubular phosphate transporters and include hereditary hypophosphataemic rickets with hypercalciuria (HHRH) and X-linked recessive hypophosphataemic rickets. The radiographical changes and clinical features of rickets in various types of HR are similar but not identical. Short stature, bone deformities mainly in the lower limbs, and dental problems are typical characteristics of HR. Although the initial diagnosis of HR is usually based on physical, radiological, and biochemical features, molecular genetic analysis is important to confirm the diagnosis and differentiate the type of HR. In this review, we describe clinical and biochemical features as well as genetic causes of different types of HR. The clinical and biochemical characteristics presented in this review can help in the diagnosis of different types of HR and, therefore, direct genetic analysis to look for the specific gene mutation.

A Week of Mayhem: The July 30 Insurgency in the Gambia

The paper explains the emergence of political parties in The Gambia before and after independence and how they fared during presidential and parliamentary elections till an insurgency nearly toppled the regime. It also examines the causes of different types of coups, and relates it to the Gambian situation, thereafter a detailed eyewitness account of the insurgency followed. The role played by invading Senegalese forces in quelling the uprising and restoring law and order received attention. The findings show that economic problems, corruption, and carefree attitude of the ruling oligarchy were among the causes of the attempted overthrow.

Deformations of the Image of the World of Youth in the Process of Socialization

The article analyzes psychological peculiarities of the image of the world and personal manifestations of the character of students with different forms of behaviour disorders. The types of image of the world and the personal traits of the character are analyzed. The peculiarities of the worldview of schoolchildren with aggression, autoaggression, overpriced hobbies, and emotional disorders are revealed. The influence of the image of the world on defects of the self-image and behaviour disturbance is established. The influence of a negative emotional background of the image of the world on the formation of dependent forms of behaviour is determined. It has been proven that the psychological correction of students with adaptation problems should include programs to stimulate a positive experience of the world and to restore an internal equilibrium. The directions of further exploration of the problems of psychology of addictive behaviours are outlined.During puberty, significant behavioral abnormalities may occur in children. With timely psychological and pedagogical intervention, destructive manifestations are situational or episodic. If parents and pedagogues do not resort to psychological correction, negative models of interaction between the teenager and the world become unlikely to overturn, and the troublesome behaviour becomes irreversible.The results of the study of the image of the world and the personal traits of students with different behavioral abnormalities are presented in this article.For example, it has been found that the adolescents’ use of profanity in communication with peers is caused solely by mechanisms of imitation and identification of the image of the world inherent in their family or social environment. In other words, there is a negative stimulation of the development of the image of the world of the child, the outward manifestation of aggressive behaviour. This, in turn, testifies to emotional-volitional instability and accentuation of character. Thus, the teenager demonstrates his/her “adulthood”.The article analyzes the causes of different types of addictive behaviour of young people: tobacco, gaming, computer, and more.Psychological correction in such cases should be aimed at establishing a dynamic equilibrium of the system “Image of the world – image of I”. That is, the child’s consciousness tries to adapt to the external conditions of being in a certain space, and this affects his/her behaviour. Under these conditions, responses may differ from generally accepted social norms.Stimulating self-development of the person and helping the teenager to form a realistic, content-rich worldview will positively affect the development of personal reflection and rethinking of one’s self-image.

Distribution Characteristics of Geological Disasters and Main Control Measures in Shandong Province

The landforms and geological structures in Shandong Province are relatively complex, and the complex topographical conditions and geological structures have caused a series of geological problems. This article outlines the main types of geological disasters in Shandong Province through literature research and geological survey, summarizes the distribution characteristics and causes of different types of geological disasters in Shandong Province, describes the prevention and control status of various geological disasters, and proposes future research recommendations on geological disaster management. Through the analysis and data compilation of a large number of geological disaster cases in Shandong Province, the research results show that the hidden dangers of geological disasters in Shandong Province are mainly subsidence, landslides, debris flows and ground subsidence, which are mainly distributed in the eastern, southern and central parts of Shandong Province. Its development law is closely related to the topography, stratum lithology, and geological structure, engineering geological characteristics, hydrogeological characteristics and human-made engineering activities of the study area. Existing geological disaster control measures focus on eliminating hidden dangers, but the results of environmental management are few. Therefore, in the future, efforts should be made to research on geological disaster prevention and control engineering based on ecological protection and form ecological management that combines management engineering with natural and human engineering technology. This article aims to systematically introduce the major geological disasters and their distribution characteristics in Shandong Province, make up for the lack of existing research results, and provide a scientific basis for future research on geological disasters.

Congenital Malformations in Sea Turtles: Puzzling Interplay between Genes and Environment.

Simple SummaryCongenital malformations can lead to embryonic mortality in many species, and sea turtles are no exception. Genetic and/or environmental alterations occur during early development in the embryo, and may produce aberrant phenotypes, many of which are incompatible with life. Causes of malformations are multifactorial; genetic factors may include mutations, chromosomal aberrations, and inbreeding effects, whereas non-genetic factors may include nutrition, hyperthermia, low moisture, radiation, and contamination. It is possible to monitor and control some of these factors (such as temperature and humidity) in nesting beaches, and toxic compounds in feeding areas, which can be transferred to the embryo through their lipophilic properties. In this review, we describe possible causes of different types of malformations observed in sea turtle embryos, as well as some actions that may help reduce embryonic mortality.The completion of embryonic development depends, in part, on the interplay between genetic factors and environmental conditions, and any alteration during development may affect embryonic genetic and epigenetic regulatory pathways leading to congenital malformations, which are mostly incompatible with life. Oviparous reptiles, such as sea turtles, that produce numerous eggs in a clutch that is buried on the beach provide an opportunity to study embryonic mortality associated with malformations that occur at different times during development, or that prevent the hatchling from emerging from the nest. In sea turtles, the presence of congenital malformations frequently leads to mortality. A few years ago, a detailed study was performed on external congenital malformations in three species of sea turtles from the Mexican Pacific and Caribbean coasts, the hawksbill turtle, Eretmochelys imbricata (n = 23,559 eggs), the green turtle, Chelonia mydas (n = 17,690 eggs), and the olive ridley, Lepidochelys olivacea (n = 20,257 eggs), finding 63 types of congenital malformations, of which 38 were new reports. Of the three species, the olive ridley showed a higher incidence of severe anomalies in the craniofacial region (49%), indicating alterations of early developmental pathways; however, several malformations were also observed in the body, including defects in the carapace (45%) and limbs (33%), as well as pigmentation disorders (20%), indicating that deviations occurred during the middle and later stages of development. Although intrinsic factors (i.e., genetic mutations or epigenetic modifications) are difficult to monitor in the field, some environmental factors (such as the incubation temperature, humidity, and probably the status of feeding areas) are, to some extent, less difficult to monitor and/or control. In this review, we describe the aetiology of different malformations observed in sea turtle embryos, and provide some actions that can reduce embryonic mortality.

Glycans to improve efficacy and solubility of protein aggregation inhibitors.

Glycans to improve efficacy and solubility of protein aggregation inhibitors.

NOL4 is Downregulated and Hyper-Methylated in Papillary Thyroid Carcinoma Suggesting Its Role as a Tumor Suppressor Gene.

BackgroundThyroid cancer is the fourth most common cancer in the world. Papillary thyroid carcinoma (PTC) accounts for 80% of all types of thyroid neoplasm. Epigenetic alterations such as DNA methylation are known as the main cause of different types of cancers through inactivation of tumor suppressor genes.ObjectivesIn the present study, the expression and methylation of suggested gene namely nucleolar protein 4 (NOL4) in PTC in comparison to multi nodular goiter (MNG) have been studied.MethodsForty-one patients with PTC and 38 patients affected by MNG were recruited. Thyroid tissues were obtained during thyroidectomy. RNA and DNA were extracted from thyroid tissues. Quantitative RT-PCR assay was performed for determining the mRNA level of NOL4 while methylation-sensitive high resolution methylation was applied for assessing the methylation status with designing six pairs primers for six regions on gene promoter which were named from NOL4 (a) to NOL4 (f).ResultsMethylation assessment of 81 CpG islands in the promoter region of NOL4 gene revealed that NOL4 (f), the nearest region to the start codon, was significantly hypermethylated in PTC cases compared to MNG cases. NOL4 level in PTC cases in comparison with MNG cases were downregulated. The methylation status and mRNA level of NOL4 (f) were associated with age of diagnosis (Age of the patient at the time of diagnosis), lymph node metastasis, and advanced stages of disease.ConclusionsThese data suggested an aberrant promoter hyper-methylation of NOL4 in PTC cases may be linked with its downregulation. Therefore, NOL4 gene can be proposed as a potential tumor suppressor gene in PTC tissues.

Cerebral small vessel disease’s impact on the development of chronic cerebral ischemia: paradigms of treatment

The article is dedicated to the issues of treatment of cerebral small vessel disease (CSVD), one of the most common pathological processes that is a leading cause of different types of cerebrovascular disorders and cognitive impairment. It also discusses the reasons for the development of small vessel pathology, which is usually referred to as the “chronic cerebral ischemia” in the Russian neurology. Emphasis is made on the etiopathogenetic factors affecting small calibre vessels, in which the metabolic-angiogenic mechanisms, in particular endothelial dysfunction and oxidative stress, are dominant.Difficulties in studying CSVD are explained by the disease course features and the insufficient introduction of unified approaches to the terminology and diagnosis. The article presents new data on the pathogenesis of small vessel disease based on the clinical and pathological findings and achievements of neuroimaging. A modern classification is provided, the clinical manifestations of vascular cognitive disorders associated with chronic cerebrovascular insufficiency are described in detail.The authors consider the issue of choosing and using drugs for the treatment of cerebrovascular diseases through the lens of understanding their own clinical experience and scientific research findings. They provide data of their own research on the antioxidant status and changes in the phospholipid composition of blood plasma in patients with chronic cerebral ischemia during separate and combined administration of 2-ethyl-6-methyl-3-hydroxypyridine-succinate (Neurox) and citicoline (Neupilept), which are natural metabolites and are involved in biochemical processes throughout the body. Based on the literature review and their own data, the authors conclude that complex pharmacological therapy can be effectively used in patients with CSVD, which is due to various points of “application” of pharmacological activity in the pathogenetic processes chain.