“I have to think about why anyone would want to remember particular pieces of information. What does this fact help you understand? What problems does it help you address?” —As quoted in Ken Bain's What the Best College Teachers Do, 20041 How old were you when you heard the word epidemiology for the first time? At what stage in your career did you take your first epidemiology course? What events and decisions had to align for these events to occur? Did that alignment occur because of a well-conceived plan or was it more or less by serendipity? Many, if not most, answers to these questions from members of the public health community will include “graduate school” and/or “serendipity.” As the size of the public health workforce dwindles and its responsibilities increase, it is time to ensure that the answers future cohorts give to these questions will include “middle and high school” and “a well-conceived plan.” Younger students can learn epidemiology and understand its role in public health. The inductive and deductive reasoning of epidemiologic sleuthing captures students' curiosity. The limitations of epidemiologic study designs and the making of causal judgments when evidence is missing and/or flawed can challenge the critical-thinking skills of the best of students. Designing public health strategies based on such evidence can stir even the most laid-back student's sense of right and wrong. And all of this engagement is heightened when the issues being explored are of immediate relevance, whether it be backpacks and back pain, watching television and being overweight, or sleep deprivation and academic performance. If students have these experiences when the career-path playing field is still level, it seems likely that more of them will consider careers in public health. More importantly, perhaps, is the benefit to the majority of these students, whether or not they opt for public health careers. Knowledge of epidemiology arguably will prepare students to become more scientifically literate personal and public health decision makers, who will be able to appreciate epidemiologic evidence and provide support for public health initiatives. While epidemiology can be viewed as a required core course for public health professionals, it has more than simply vocational value. Even if public health workforce issues were no longer a problem, there would still be a legitimate scientific literacy argument for infusing epidemiology education into the curricula of grades 6–12. Are biology, chemistry, and physics taught for merely vocational purposes? This article begins to address what will be a necessary, but not sufficient, component of a well-conceived plan—deciding what sort of professional development experiences need to be created to prepare middle school and high school teachers to teach epidemiology, a science about which few have had previous knowledge. What epidemiologic knowledge is needed to teach epidemiology effectively? How can teachers be prepared to teach this science? To begin to plan the professional development experiences that prospective grade 6–12 epidemiology teachers would need, we might take a few epidemiology textbooks off our shelves and, paying particular attention to the tables of contents, begin to create a list of topics. We might recall some favorite epidemiology lessons we experienced as students. We might start to create a collection of assigned readings such as a textbook, a combination of historical epidemiology-related documents, some dramatic case studies, and some current newspaper columns. For a change of pace, we might think of a video and a guest speaker or two. In short, we might begin to plan this professional development by thinking about what we, as providers of professional development, will do. We might plan this professional development as a series of activities during which we cover an assortment of epidemiologic topics that are sure to engage budding teachers of epidemiology. All of this may be of value, but the National Research Council (NRC) warns that learners “… presented with vast amounts of content knowledge that is not organized into meaningful patterns are likely to forget what they have learned and to be unable to apply the knowledge to new problems or unfamiliar contexts.”2 Needless to say, a new teacher of epidemiology does not want to be in this situation when a student asks a question. The NRC concludes, “Learning with understanding is facilitated when new and existing knowledge is structured around the major concepts and principles of a discipline.”2