African catfish farmers used animal waste as feed to reduce production costs, a practice that raised concerns among consumers, causing them to avoid it. Consequently, this study aimed to explore factors that influenced the acceptance of farmed African catfish. The data survey involving 2294 participants from Egypt was analyzed using descriptive statistics and the chi-square test. The results indicated that 67% of participants abstained from consuming it, while 2.30% consumed it regularly. The chi-square test revealed significant consumption pattern variations (p < 0.05) based on most demographic factors. Entirely, 43% were uninformed about the nutritional value, market availability, and the potential impact of using aquafeeds on pricing. About 55–57% lacked information on feeding practices, had quality concerns, viewed catfish consumption as a health risk, and were unaware of its prices. Additionally, 68% were worried about pollution, and 76% found the available information insufficient. The main reasons for this challenge lie in consumers’ health, religious, and psychological concerns. To address this, we propose a targeted marketing strategy focusing on improving safety and quality through safe and cost-effective aquafeeds. This involves requiring farmers to obtain quality certifications and adhere to best management practices, adding value to the product, and transparent communication with consumers to provide them with reliable information about cultivation practices and the nutritional value of African catfish. Effective collaboration among key stakeholders in implementation, efficient sector management, establishing an activity licensing system, and prohibiting current feeding practices will enhance sustainable demand and reverse the declining production trend of this promising species.