We present the results of observations of the Galilean moons of Jupiter carried out at the Normal Astrograph of the Pulkovo Observatory in 2018. We obtained 452 positions of the Galilean moons of Jupiter in the Gaia DR1 catalog system (ICRF, J2000.0) and 671 differential coordinates of the satellites relative to each other. The obtained mean errors in the satellites’ normal positions on the right ascension and declination, which demonstrate the intrinsic convergence of the observational results, are eα = 0.003′′ and eδ = 0.003′′, respectively, for the entire observational period. The errors of one difference are σα = 0.070′′, and σδ = 0.067′′, respectively. The equatorial coordinates of the moons were compared to eight motion theories of planets and satellites. On average, the (O–C) residuals in the both coordinates relative to the motion theories are 0.014′′. The best agreement with observations is achieved by combination of all four motion theories of satellites with the planetary theory EPM2017, which yields average (O–C) residuals of approximately 0.01′′ for each of them. The new results were compared to those of the 2016−2017 observational season. As in the past, peculiarities in the behavior of the (O–C) residuals for Io and Ganymede have been noticed.