Owing to the expensive applications of nanoparticles in engineering sciences, an admirable attention has been intended by researchers on this topic in recent years. The utilization of nanoparticles as asource of energy is intended much attention of investigators in recent decade. This novel attempt investigates the thermal properties of Casson nanofluid containing microorganisms induced by an oscillatory moving surface. The fundamental features of heat and mass phenomenon are inspected by utilizing the temperature-dependent viscosity. Buongiorno’s mathematical model is used to report the famous Brownian motion and thermophoretic diffusion consequences. The flow problem characterizes the partial differential equations for which analytical solution has been computed with a convincible accuracy. The insight physical features are inspected with help of various curves. The physical significances of flow parameters is studied via various graphs.