Cases Of Salivary Gland Tumors Research Articles

Malignant Salivary Gland Neoplasm of the Tongue Base with EWSR1::BEND2 Fusion: An Unusual Case with Literature Review.

Salivary gland malignancies may have overlapping architectural patterns, tumor morphology, and immunohistochemical phenotypes, presenting challenges in precise classification. Molecular phenotyping has become quite useful for providing an additional diagnostic modality, and potential drug targets. Here we reported a young female patient with salivary gland tumor of the tongue base harboring genetic alterations by next generation sequencing (NGS). The morphological, immunohistochemical and molecular features of this case were described, and related literature was reviewed. The tumor showed an epithelial myoepithelial architecture arranged in cords and tubules interwoven with a chondromyxoid stroma, along with perineural invasion and adjacent striated muscle infiltration. Myoepithelial cells were positive for CK5/6, partially positive for P63 and CK7, and sporadically positive for S100. Immunoprofiling revealed a low density of infiltrating lymphocytes and macrophages and the absence of programmed death ligand 1 (PD-L1). Notably, RNA-based NGS showed EWSR1::BEND2 gene fusion in this tumor, and EWSR1 break-apart was confirmed by fluorescence in situ hybridization. This led to a final diagnosis of a minor salivary gland malignancy with EWSR1::BEND2 fusion. Only two other cases of salivary gland tumors with EWSR1::BEND2 fusion had been previously reported, which were also detected via RNA-based NGS. This study emphasized that EWSR1::BEND2 fusion may drive the carcinogenesis in salivary glands neoplasia. In clinic RNA-based NGS could be essential for precise genotyping of EWSR1 fusion in this rare disease.

Akurasi Biopsi Aspirasi Jarum Halus untuk Diagnostik Tumor Kelenjar Liur di RSUD DR Saiful Anwar Malang 2018-2022

Fine needle aspiration biopsy is accepted as a safe, reliable, minimally invasive, and cost-effective method. Fine needle aspiration biopsy aims to assist clinicians in handling patients. The purpose of this study is to evaluate the validity of fine needle aspiration biopsy as a diagnostic tool in salivary gland tumors compared to histopathological examination at Dr. Saiful Anwar Malang Hospital for the period of 2018-2022. Methods: Fine needle aspiration biopsy examination was performed before surgery, then compared with the results of histopathological examination after surgery as gold standard and retrospectively reviewed. Fine needle aspiration biopsy results and histopathological results are classified as neoplasm or non-neoplasm and benign or malignant. Validity is determined from sensitivity, specificity, positive conjecture value, negative conjecture value and accuracy. As a result, there were 33 cases of salivary gland tumors that met the inclusion criteria in the period 2018-2022 were reviewed, then classified into neoplasms or non-neoplasms and benign or malignant neoplasms. The sensitivity, specificity, accuracy, positive presumptive value, and negative presumptive value of cytological diagnosis of fine needle aspiration biopsy of salivary gland tumors for the neoplasm or non-neoplasm category were 93.1%, 100%, 93.9%, 100%, 66.7% and for the benign or malignant category 94.4%, 88.9%, 92.6%, 94.4%, 88.9%. This study shows that salivary gland fine needle aspiration biopsy cytology is a reliable and accurate diagnostic method for the diagnosis of salivary gland lesions. Conclusions: Fine needle aspiration biopsy is a useful method for diagnostics in salivary gland tumors but cannot replace histopathological examination as the gold standard for diagnostics.

Insulin Like Growth Factor II mRNA-Binding Protein 3 (IMP3) Immunohistochemical Expression in Salivary Glands Tumors- Local Study

Objective: To identify the relationship between the expression of IMP3 in benign and malignant tumors of salivary glands and other clinic-pathological variables. Materials and Methods: Twenty-six cases of salivary gland tumors were collected from the histopathology department, Gazi-Hariri hospital/ Baghdad Medical City from January 2021 to June 2021. Patients’ reports were included for diagnosis and clinicopathological data. Three histological sections were taken from the paraffin blocks for each case. The first section was stained with H&E stain, and the other two sections were stained with IMP3 (Dako-code M3626) monoclonal antibody by the immunohistochemical method. Results: Twenty-six cases of salivary gland tumor, with equal male/female distribution; the mean age for the patients was 45 years (19-60 years). There was no significant relationship between gender (P=.0.115), tumor size (P=0.359), tumor location (P=0.335), and tumor type (P=0.673) with positive expression of IMP3. Regarding malignant cases, no significant relation between IMP3 expression and tumor stage (P=1.000), and lymphovascular invasion (P=1.000). On the other hand, there was a highly significant relationship (P=0.000) between IMP3 expression and cell type (epithelial/mesenchymal). Conclusion: Imp3 might not be conclusive in differentiation between benign and malignant salivary gland tumors. Further studies with follow-up are needed to assess the prognostic value of this marker in salivary gland pathologies.

Epidemiology of Mucoepidermoid Carcinoma of Minor Salivary Glands: A Single-Institution Experience in Mumbai, Maharashtra over 20 Years

Introduction: Encountering a soft tissue swelling in the oral cavity during routine dental practice is infrequent yet practical. Salivary gland tumours of the oral mucosa are associated with minor salivary glands, although they are uncommon and can be considered as a differential diagnosis. Mucoepidermoid Carcinoma (MEC) constitutes a significant percentage of salivary gland tumours of minor salivary glands and exhibits varied biological behaviour. Aim: The aim of the present study was to investigate the clinical and histological characteristics of MEC of the minor salivary glands to comprehend the epidemiological pattern of these tumours and compare the findings with those of other studies. Materials and Methods: For this cross-sectional study, data on salivary gland tumours were accessed from the Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Mumbai, archives spanning from 2003 to 2022 (a 20-year period). Out of the 22 reported cases of salivary gland tumours, 12 cases were identified as MEC. Clinical details and slides of these MEC cases were obtained from the departmental archives and graded according to Brandwein MS grading. The patients’ clinical features were described through descriptive analysis using SPSS software. Results: Based on gender distribution, there were 8 (66.66%) females and 4 (33.33%) males. The age distribution of the patients revealed that the maximum number of patients (n=4, 33.33%) belonged to the 4th decade of life. The site involvement, in ascending order, included the palate (n=10; 83.83%), alveolus (n=1), and upper anterior gingiva (n=1). Regarding laterality, 7 (58.33%) cases were on the right-side, and 5 (41.66%) were on the left-side of the palate. Conclusion: The study found that females in their 4th decade were commonly affected, with the palate being the most commonly affected site. MEC is one of the common differential diagnosis to consider, and its aggressiveness and treatment planning are related to histological grading. Therefore, epidemiological studies from different parts of the globe are needed to provide a better understanding of the lesion’s biological behaviour, common sites, gender, and age predilection.

EXPRESSION OF SOX2 AND CLINICOPATHOLOGICAL SIGNIFICANCE IN SALIVARY GLAND TUMORS

<h3>Objectives</h3> To analyze the expression of the sex-determining region of Y chromosome-related high-mobility-group box 2 (SOX2), a putative marker of cancer stem cells in salivary gland tumors (SGTs). <h3>Study Design</h3> One hundred fifty-four cases of SGT were selected (103 malignant and 51 benign neoplasms). SOX2 expression was detected by immunohistochemistry and confirmed by Western blotting, following a semiquantitative evaluation. <h3>Results</h3> SOX2 was identified in the parenchyma of malignant (<i>n</i> = 54; 52.4%) and benign (<i>n</i> = 12; 23.5%) neoplasms, especially in tumors without myoepithelial differentiation (canalicular adenoma, Warthin's tumor, mucoepidermoid carcinoma, clear cell carcinoma; <i>P</i> < .05). Tumors with myoepithelial differentiation showed negative or low expression of SOX2 (pleomorphic adenoma, basal cell adenoma, myoepithelioma, adenoid cystic carcinoma, basal cell adenocarcinoma, epithelial-myoepithelial carcinoma). No association was found between SOX2 expression and clinicopathologic parameters (<i>P</i> > .05). A positive correlation between SOX2 expression by immunohistochemistry and Western blotting techniques was observed (<i>r</i> = 0.967; <i>P</i> < .001). <h3>Conclusions</h3> These results indicate that SOX2 was differentially expressed among the SGTs studied, predominantly in malignant tumors, suggesting that cells with cancer stem cell–like phenotype may be involved in the carcinogenesis and progression of SGT.

PRELIMINARY RESULTS: EPIDEMIOLOGICAL MULTICENTRIC SURVEY OF SALIVARY GLAND TUMORS IN CHILDREN AND ADOLESCENTS

<h3>Objectives</h3> Salivary gland tumors (SGTs) are a diverse group of uncommon neoplasms that are rare in pediatric patients. The aim of this study was to characterize the clinicopathologic profile of pediatric patients affected by SGTs. <h3>Study Design</h3> We retrospectively analyzed the cases of SGTs in children and adolescents (0-19 years old) diagnosed between 2000 and 2020, for a total of 114 cases. Patients' clinical data were obtained from medical records. The lesions were classified according to the 2017 World Health Organization criteria. Quantitative analysis of the data was performed using SPSS. <h3>Results</h3> The lesions were more prevalent in females (54.4%), the average age was 13.6 years, and 60.5% were over 14 years old. The palate was the most affected site (62.3%), followed by 11.4% in the lip and 8.8% in the parotid. In addition, 26% had painful symptoms. Most cases were benign tumors, 70.2% were pleomorphic adenoma, and 19.3% were mucoepidermoid carcinoma. <h3>Conclusions</h3> In parallel with previous studies, we found that pediatric STGs have a higher frequency of benign and nonmalignant tumors.

A Clinicopathological Analysis of 75 Salivary Gland Tumors at Mayo Hospital, Lahore

Aim: To describe the clinic-o-pathological pattern of patients presented with salivary gland tumors at Department of Maxillofacial surgery Mayo hospital Lahore during time period of one year from 1st January 2019 to 31st December 2019. Methods: This was a retrospective cross-sectional study conducted at Department of Oral and Maxillofacial Surgery, Mayo Hospital Lahore. 75 cases of Salivary gland tumors in the head and neck region were identified. Patient’s medical record and pathology reports were retrieved and carefully reviewed by a senior doctor to collect basic demographic data as well as tumor related information. Data entry and analysis was done with the help of SPSS version-26. Chi Square Test/Fisher exact test was applied to see the association between qualitative variables. Results: In this study Mean age of patients in this study was 40.45±13.18. Male patients were predominant as compared to female patients; Male 53.3% &amp; Female 46.7%.The most frequent tumor among patients was Pleomorphic Adenoma (61.3%) followed by Adenoid Cystic Carcinoma (17.3%), Mucoepidermoid Carcinoma (13.3%), Warthin’s Tumor (4%), Squamous cell Carcinoma of Parotid (2.7%) and adenocarcinoma (1.3%) respectively. However no significant association was seen between salivary gland tumors with age and gender of patients (p-value=0.521). Conclusion: Among the benign salivary gland tumors pleomorphic adenoma is the most common tumor whereas among malignant salivary gland tumors adenoid cystic carcinoma is the most frequent occurring tumor. Keywords: Salivary gland Tumors, Maxillofacial Surgery, Pathological Pattern,

A Histopathology-based Assessment of Biological Behavior in Oral Hyalinizing Extraosseous Lesions by Differential Stains

The assessment of hyalinization to determine aggressive behavior in oral pathological lesions is a scarcely researched field that requires further exploration. The current study aims to predict the biological behavior of oral hyalinizing extraosseous lesions (OHEOL) by employing four differential stains with clinicopathologic correlation. The study was performed on retrospectively diagnosed formalin-fixed paraffin-embedded cases of salivary gland tumors (SGTs) (n = 13), benign soft tissue (BST) lesions (n = 24), and oral submucous fibrosis (OSMF) (n = 53). The hematoxylin and eosin-stained sections were analyzed for the severity of hyalinization (SOH). Differential stains periodic acid Schiff (PAS), Alcian blue, safranin O, and picrosirius red with polarizing microscopy were used to assess the components of hyalinized tissue. The SOH was correlated with differential staining characteristics and clinicopathologic features to analyze possible correlation with aggressive potential in BST, advancement of disease in OSMF, and recurrence in SGT. Intensity of picrosirius red stain significantly correlated with SOH of SGTs (p = 0.044). The intensity of PAS stain (p = 0.040), picrosirius red polarizing greenish-yellow color (p = 0.002), and pattern of distribution of picrosirius red (p = 0.023) significantly correlated with recurrence of SGTs. The intensity of differential stains increased with the SOH in BST lesions indicating their correlation with SOH. The intensity (p = 0.008) and pattern (p = 0.010) of Alcian blue staining and intensity of safranin O stain (p = 0.003) significantly correlated with SOH in OSMF. Picrosirius red polarizing color reddish and yellowish red (p = 0.002) significantly correlated with SOH distinguishing early and advanced OSMF. Picrosirius red and PAS stains are reliable indicators of SOH and recurrence potential in SGT. Alcian blue, safranin O, and picrosirius red polarizing colors enable detection of SOH and accurately distinguish early from advanced OSMF. SOH can be considered as a histological predictor of aggressive biologic behavior in OHEOL. These findings will result in appropriate management protocols.

Salivary Gland Tumors: a Ten-Year Retrospective Analysis in a Brazilian Teaching Hospital

Introduction: The tumors affecting salivary glands have a wide morphological diversity. Objective: This study aimed to examine the prevalence of salivary gland tumors in patients treated at São Lucas Teaching Hospital at the Pontifical Catholic University of Rio Grande do Sul (HSL-PUCRS), in Porto Alegre (RS), Brazil, from 2007 to 2016. Method: A retrospective study analyzing 201 files from the Department of Pathology at the HSL-PUCRS was carried out, by revising the medical records. Results: Seventy-three cases of salivary gland tumors were found, and their electronic and physical medical records were analyzed. Of the 73 cases, 56 (76.7%) were benign tumors and 17 (23.3%) were malignant tumors. The age group with the highest number of cases was between 41 and 60 years of age and the highest prevalence was found in females, with 54.8% of the cases. The parotid gland presented the highest prevalence, accounting for 72.6% of the cases. The predominant neoplasia was the pleomorphic adenoma, accounting for 53.4% of the tumors. The standard of distribution of neoplasms of salivary glands was similar to the encountered in other Brazilian regions. Conclusion: The largest salivary glands were the most affected by neoplastic processes. Pleomorphic adenoma and adenoid cystic carcinoma were the most frequent benign and malignant tumors, respectively, and parotid gland was the most affected site. In the light of previous literature data, the results allow to infer that some demographic characteristics (for example, sex and age) vary among the different geographic regions.

Adenocarcinoma of the minor salivary gland with concurrent &lt;i&gt;MAML2&lt;/i&gt; and &lt;i&gt;EWSR1&lt;/i&gt; alterations

Salivary gland tumors are histologically diverse, and each entity has distinctive histopathological and molecular features. We report two cases of salivary gland tumors with unique histological and molecular findings, which have not been documented previously. The tumors were located in the base of the tongue in both patients. Most tumor cells were arranged in cords and nests, giving a trabecular-like appearance. Focally, glandular structures with intraluminal mucin and perivascular pseudorosette-like configurations were identified. Tumor cells had eosinophilic to clear cytoplasm, and showed mild nuclear atypia. They were positive for pancytokeratin and negative for S-100, p63, c-KIT, androgen receptor, and neuroendocrine markers. Multiple foci of capsular or lymphovascular invasion were identified, but the Ki-67 labeling index was low (< 5%). Fluorescence in situ hybridization revealed concurrent alterations of MAML2 and EWSR1 gene. Further investigations with a larger number of cases with similar histological and molecular features will accurately classify this tumor.

Salivary Gland Tumors: A Retrospective Study of 164 Cases from a Single Private Practice Service in Mexico and Literature Review.

Salivary gland tumors (SGT) represent an uncommon heterogeneous group of tumors with complex clinical and pathological characteristics. The prevalence of these lesions varies between studies but has been estimated between 3 and 6% of all tumors in the head and neck region. The present study aimed to evaluate the distribution and demographic findings of salivary gland tumors diagnosed in an oral pathology service in Mexico. A retrospective descriptive cross-sectional study was performed. A total of 164 cases of SGT from a private oral pathology service were diagnosed between 2000 and 2019 in Mexico City. All cases were reviewed histologically, and demographic data and histopathological diagnoses were collected. A total of 110 (67.1%) tumors were benign, and 54 (32.9%) were malignant. The majority of patients were female (n = 100, 61.0%) with an overall female:male ratio of 1.6:1. The minor salivary glands were affected more than the major salivary glands (68.9% vs. 25.6%). The palate (n = 67, 40.9%) was the most commonly affected site, followed by the parotid gland (n = 37, 22.6%), lips (n = 16, 9.8%), and buccal mucosa (n = 14, 8.5%). Pleomorphic adenoma (n = 88; 80.0%) and mucoepidermoid carcinoma (n = 16, 29.6%) were the most frequent benign and malignant tumors, respectively. The general features of SGT from the studied Mexican population shared some similarities and differences compared to previously reported series from various parts of the world.

Correlation between magnetic resonance imaging and extemporaneous and definitive histological examination of parotid gland tumors: a case series

La pathologie tumorale de la glande parotide est complexe et pose des problèmes aussi bien diagnostiques que thérapeutiques. Notre objectif était d´évaluer la place de l'examen extemporané dans la prise en charge des tumeurs parotidiennes. Nous rapportons une étude analytique pro et rétrospective sur une série de cas présentant une tumeur parotidienne, colligés au service d'ORL et de chirurgie cervico-faciale du CHU de Casablanca, entre janvier 2012 et décembre 2015. Nous avons noté 72 cas de tumeurs parotidiennes. Le sexe-ratio (H/F) est de 0,94, il était de 0,76 pour les tumeurs bénignes et de 1,62 pour les tumeurs malignes. La moyenne d'âge de nos patients est de 47 ans (15-75 ans). Le délai moyen de consultation est de 40 mois. La symptomatologie clinique était dominée par la tuméfaction parotidienne (100%), la douleur chez 25% des patients, la paralysie faciale chez 6%, et les adénopathies cervicales chez 10%. L'échographie était demandée dans 80%. L'IRM était réalisée dans 26% des cas. Tous nos patients ont bénéficié d'un traitement chirurgical, 76% de parotidectomies exo-faciales et 24% de parotidectomies totales conservatrices. Ce traitement a été associé à un évidemment ganglionnaire dans 24% des cas et d´une radiothérapie dans 24%. L´examen extemporané a été réalisé chez 71% des patients, sa sensibilité était de 89% et sa spécificité était de 88%. Le diagnostic définitif de la nature histologique a été confirmé par l'examen anatomopathologique dans tous les cas. Nous avons confirmé la nature bénigne et maligne de la tumeur respectivement dans 71% et 29%. L'adénome pléomorphe a dominé les tumeurs bénignes (59%), alors que les lésions malignes étaient dominées par le carcinome muco-épidermoïde (38%). Les suites opératoires étaient marquées par: un discret hématome dans 4%, une paralysie faciale transitoire dans 15%, une surinfection de la plaie dans 3% et un syndrome de Frey post parotidectomie chez 3% des patients. Un cas de récidive labiale d´un carcinome à cellule acineuse. Aucun cas de décès n´a été noté. Les tumeurs de la glande parotide se caractérisent par une grande diversité histologique. La différenciation entre une tumeur maligne et une tumeur bénigne est souvent délicate. Actuellement l´IRM permet d´apporter plus de renseignements. L´extemporané est d´une aide précieuse en peropératoire qui nécessite une communication avec l´anatomopathologiste. Sa prise en charge est pluridisciplinaire, ORL, onco-radiothérapeute, anatomopathologiste et radiologue. Le pronostic dépend du type histologique, du stade évolutif et du traitement.

MYOEPITHELIOMA IN THE MINOR SALIVARY GLAND

Myoepithelioma is a rare salivary gland neoplasm composed almost entirely of myoepithelial cells, with few ductal elements. The myoepithelial cells can be spindle, plasmacytoid, hyaline, or epithelioid and may also present a clear cytoplasm. This neoplasm occurs most often in the parotid gland and accounts for less than 7% of all cases of salivary gland tumors. A 75-year-old woman presented a painless tumor on the hard palate. The lesion was normochromic and had a smooth surface. The patient had been submitted to a previous incisional biopsy with a histopathologic diagnosis of myoepithelioma. After total excision of the lesion, the histopathologic examination showed a neoplasm composed of many spindle cells as well as some plasmacytoid and epithelioid cells on a myxomatous stroma. Rare ductal formations were noted. An immunohistochemical study was performed and showed positivity for S100, CK7, CK14, pan cytokeratin, smooth muscle actin , calponin, P63, and glial fibrillary acidic protein, confirming the diagnosis of myoepithelioma. Myoepithelioma is a rare salivary gland neoplasm composed almost entirely of myoepithelial cells, with few ductal elements. The myoepithelial cells can be spindle, plasmacytoid, hyaline, or epithelioid and may also present a clear cytoplasm. This neoplasm occurs most often in the parotid gland and accounts for less than 7% of all cases of salivary gland tumors. A 75-year-old woman presented a painless tumor on the hard palate. The lesion was normochromic and had a smooth surface. The patient had been submitted to a previous incisional biopsy with a histopathologic diagnosis of myoepithelioma. After total excision of the lesion, the histopathologic examination showed a neoplasm composed of many spindle cells as well as some plasmacytoid and epithelioid cells on a myxomatous stroma. Rare ductal formations were noted. An immunohistochemical study was performed and showed positivity for S100, CK7, CK14, pan cytokeratin, smooth muscle actin , calponin, P63, and glial fibrillary acidic protein, confirming the diagnosis of myoepithelioma.

Histopathological study of salivary gland tumours in a tertiary care hospital

Background: Salivary gland tumours constitute 3-10% of head and neck neoplasms. Their varied morphology poses challenge to pathologists as well as clinicians. Methods: The present observational study included 99 cases of salivary gland tumours. Clinical details and findings of histopathological examination were noted. Results: Mean age of the study subjects was 34.7 years. Female preponderance was seen. Most common site involved was parotid (64.7%). Most common tumour encountered was pleomorphic adenoma (76.5%). Malignant changes were seen in 17.6% cases. Most common malignant change seen was mucoepidermoid carcinoma (8.8%).Conclusion: Malignant changes were seen in 17.6% cases. Pleomorphic adenoma was the most common benign neoplasm and mucoepidermoid carcinoma was the most common malignant tumour seen.

A study of cytology and histopathology correlation of salivary gland neoplasms in a tertiary care hospital

Introduction: FNAC is a minimally invasive technique which is additionally also safe and reliable. It plays a significant role in salivary gland cytology in view of the nonuniformity of salivary gland neoplasms and therefore the limitations of incisional or core needle biopsy in salivary gland. 1 This study aims at the important role of FNAC in the preoperative diagnosis of salivary gland neoplasm. Materials and Methods: This study was done in Saveetha Medical College, Thandalam in 40 patients. The period of study was from January 201 6 to December 2017. A total of forty cases of salivary gland tumors for which both FNAC and Biopsy were accessible were solely included during this study. Results: Out of forty patients slight male predominance was noted with male: female ratio of 1.5:1. Most of the tumour were found to be in the parotid gland (31 cases) followed by submandibular gland (6 cases). Out of forty cases, twenty eight were benign and twelve were malignant. Out of twelve malignant cases, nine cases (75%) reported in cytology correlated well with histopathology. Conclusion: FNAC are often a great tool in reducing the rate of salivary gland surgery by one third of cases and in patients undergoing radical surgery. FNAC helps in coming up with an ideal surgical approach. Keywords: FNAC, Nonuniformity, Parotid, Submandibular gland, Salivary gland neoplasms.

Epidemiologic analysis of salivary gland tumors over a 10-years period diagnosed in a northeast Brazilian population

Background Salivary gland tumors (SGT) correspond to a heterogeneous group of lesions with variable biological behavior. The present study aimed to determine the distribution and demographic findings of salivary gland neoplasms in a northeast Brazilian population. Material and Methods A retrospective descriptive cross-sectional study was performed. A total of 588 cases of SGT were diagnosed between 2006 and 2016 of 4 pathology services in the state of Sergipe, Brazil. All cases were reviewed, and data such as sex, age, anatomical location, and histopathological diagnosis were collected. Results A total of 470 (79.9%) tumors were benign and 118 (20.1%) were malignant. The majority of the patients were females (n=328, 55.8%) with an overall female:male ratio of 1.2:1. The major salivary glands were affected more than the minor glands (69.5% vs. 30.5%). Pleomorphic adenoma (n=419, 71.3%) and mucoepidermoid carcinoma (n=29, 4.9%) were the most frequent benign and malignant tumors, respectively. In addition, both benign and malignant tumors occurred more frequently in the parotid gland (n=300, 51%, p<0.05). Conclusions The epidemiologic profile and clinical characteristics of SGT were similar to those described in other countries and other regions of Brazil. Epidemiological studies of SGT help to understand their clinical and pathological features and are essential to establish the proper management and prognosis. Key words:Salivary gland, tumors, epidemiology, head and neck pathology.

Salivary gland tumors: A 13-year clinicopathologic retrospective study in a Brazilian northeast population.

The present study aimed to evaluate the clinicopathologic features of salivary gland tumors (SGTs) in a Brazillian northeast population. A retrospective descriptive cross-sectional study was performed (1995-2009). All cases of SGTs diagnosed in a private surgical pathology service in Brazil were reviewed, and clinicopathological data were collected. A total of 23.258 histopathological records of biopsies were analyzed, and 174 cases were diagnosed as SGTs (0.7%). Of these, 117 (67.2%) were classified as benign, and 57 (32.8%) were malignant. The series comprised 89 females (51.1%) and 85 males (48.9%), with a mean age of 50.2 years (range: 3-96 years) and a roughly equal female-to-male ratio (1:1). Most tumors occurred in the parotid gland (n = 82, 47.1%), followed by the palate (n = 45, 25.9%), submandibular gland (n = 15, 8.6%). Pleomorphic adenoma (n = 83; 70.9%) and mucoepidermoid carcinoma (n = 19, 33.3%) were the most frequent benign and malignant tumors, respectively. After reevaluation of morphology and immunohistochemical analysis, seven tumors (4.0%) were reclassified following the current WHO Classification of the Head and Neck Tumors. The general features of SGT from the studied Brazilian population were similar to previously published reports in other countries. However, SGTs do not show any sex predilection. Although careful morphological analysis is the key to the correct diagnosis of these tumors, immunohistochemical analysis is essential to establish an accurate diagnosis in the face of challenging cases. Key words:Salivary gland tumors, epidemiology, head and neck pathology.

PROFILE AND SURVIVAL OF YOUNG ADULTS DIAGNOSED WITH SALIVARY GLAND TUMORS

Objective To describe the profile and survival of young adults diagnosed with salivary gland tumors in a reference unit from 2010 to 2015. Study Design This is a retrospective cohort study that included all individuals aged 45 years old or less, with histopathologic diagnosis of salivary gland tumors. Variables were obtained from clinical records. Descriptive analysis and the Kaplan-Meier method were used for survival analysis. Results During the study period, 13 cases of salivary gland tumors were diagnosed. The majority of the individuals were female (53.8%), with a mean age of 36 years. Lesions were predominantly located in the parotid gland (23.1%) and buccal mucosa (23.1%). The most frequent histologic types were adenoid cystic carcinoma (23.1%) and adenocarcinoma (23.1%). Most tumors were diagnosed in advanced stages of the disease (57.1%) and treated by surgery (54.5%). From the cases, 30.8% died, with a median survival time of 12 months. Conclusions Late diagnosis of salivary gland tumors has a negative influence on survival, highlighting the importance of training health care professionals for their early diagnosis. To describe the profile and survival of young adults diagnosed with salivary gland tumors in a reference unit from 2010 to 2015. This is a retrospective cohort study that included all individuals aged 45 years old or less, with histopathologic diagnosis of salivary gland tumors. Variables were obtained from clinical records. Descriptive analysis and the Kaplan-Meier method were used for survival analysis. During the study period, 13 cases of salivary gland tumors were diagnosed. The majority of the individuals were female (53.8%), with a mean age of 36 years. Lesions were predominantly located in the parotid gland (23.1%) and buccal mucosa (23.1%). The most frequent histologic types were adenoid cystic carcinoma (23.1%) and adenocarcinoma (23.1%). Most tumors were diagnosed in advanced stages of the disease (57.1%) and treated by surgery (54.5%). From the cases, 30.8% died, with a median survival time of 12 months. Late diagnosis of salivary gland tumors has a negative influence on survival, highlighting the importance of training health care professionals for their early diagnosis.

Salivary Gland Neoplasms in Indian Paediatric Population Visiting a Dental Institution

INTRODUCTION: With a probability of 50% malignancy, salivary gland tumors are not too commonly noticed in children and adolescents. Most of these have idiopathic etiology but a few pre-disposing factors have been reported in literature. We hereby report eighteen cases of paediatric salivary gland tumors in a study conducted from September 2013 to August 2018 at department of Oral and maxillofacial surgery at Tatyasaheb Kore Dental college and Research Centre, Kohlapur, Maharashtra, India..AIM &amp; OBJECTIVES: This study aimed to inspect the distribution, clinical and histopathological features of salivary gland tumours in children and adolescents.MATERIAL AND METHODS: A total of 18 cases of salivary gland tumors encountered in paediatric age group were studied and explored for age, gender, site proneness and for histopathological nature.RESULTS: Female gender had a predominance over males. Parotid tumors were more common (77.78%) as compared to tumors of submandibular glands. Six cases were diagnosed with benign tumors (pleomorphic adenoma) and rest had malignant tumors (mucoepidermoid in nature). Majority of the cases did not report undergoing any prior treatment.CONCLUSION Present study revealed that salivary gland tumors in paediatric age group are quite rare with female gender being more prone. With majority of cases being mucoepidermoid in nature, parotid gland is most commonly affected.

Retrospective study of 124 cases of salivary gland tumors and literature review.

BackgroundSalivary gland tumors are a rare and morphologically diverse group of lesions and their frequency is still unknown in several parts of the world. The knowledge of its population characteristics contributes to a better understanding of its etiopathogenesis. Objectives: This study investigated the frequency of salivary gland tumors in a region of southern Brazil and compared these data in a literature review.Material and MethodsA retrospective study was conducted of salivary gland tumors diagnosed at two pathology centers from 1995 to 2016. Patient age and gender, tumor site and frequency, histopathological diagnosis, and symptomatology were evaluated. Chi-squared tests were used to assess the associations between variables. To compare our data, we also conducted a literature review of publications in the PubMed and LILACS databases of retrospective studies of salivary gland tumors.ResultsA total of 124 salivary gland tumor cases was identified, 81 (65.3%) of which were classified as benign and 43 (34.6%) as malignant. Most tumors occurred in the parotid gland (57.2%). Pleomorphic adenoma was the most common tumor (59.6%), followed by adenocarcinoma not otherwise specified (8.8%). The tumors occurred more often in women (54.8%) than in men (45.2%). Malignant tumors were associated with pain in 31.4% of cases (p<0.05). The literature review included 35 articles from different countries. Women were most affected, with a mean age of 41.7 years. The most common benign tumor was pleomorphic adenoma (48.2%) and the most common malignant tumor was mucoepidermoid carcinoma (8.7%).ConclusionsThe results of the present study showed that salivary gland tumors are rare. The parotid gland is the most common location and pleomorphic adenoma are the most frequent lesions. The malignant tumors presented as several histological types and the incidence was variable globally. Key words:Salivary gland neoplasms, salivary gland diseases, oral surgery, epidemiology.