Epidemiologic analysis of salivary gland tumors over a 10-years period diagnosed in a northeast Brazilian population

Jl Cunha,Cd Soares,Sf Sousa,Op Almeida,Me Andrade,Ac Coimbra,Cr Oliveira,Jv Silva,Is Nascimento,Rl Albuquerque-Júnior

doi:10.4317/medoral.23532

Abstract

Background Salivary gland tumors (SGT) correspond to a heterogeneous group of lesions with variable biological behavior. The present study aimed to determine the distribution and demographic findings of salivary gland neoplasms in a northeast Brazilian population. Material and Methods A retrospective descriptive cross-sectional study was performed. A total of 588 cases of SGT were diagnosed between 2006 and 2016 of 4 pathology services in the state of Sergipe, Brazil. All cases were reviewed, and data such as sex, age, anatomical location, and histopathological diagnosis were collected. Results A total of 470 (79.9%) tumors were benign and 118 (20.1%) were malignant. The majority of the patients were females (n=328, 55.8%) with an overall female:male ratio of 1.2:1. The major salivary glands were affected more than the minor glands (69.5% vs. 30.5%). Pleomorphic adenoma (n=419, 71.3%) and mucoepidermoid carcinoma (n=29, 4.9%) were the most frequent benign and malignant tumors, respectively. In addition, both benign and malignant tumors occurred more frequently in the parotid gland (n=300, 51%, p<0.05). Conclusions The epidemiologic profile and clinical characteristics of SGT were similar to those described in other countries and other regions of Brazil. Epidemiological studies of SGT help to understand their clinical and pathological features and are essential to establish the proper management and prognosis. Key words:Salivary gland, tumors, epidemiology, head and neck pathology.

Highlights

Introduction of experienceImmunohistochemical and histochemical analyses were performed when routine staining was not sufficient to establish the final diagnosis. - AnalysisDescriptive and quantitative data analysis was performed using the Statistical Package for the SocialSciences for Windows 20.0 (SPSS, Inc., Chicago, IL, USA)
The objective of the present study was to describe the demographic and clinical aspects of salivary gland neoplasms diagnosed in 4 reference pathology centers in the state of Sergipe (Aracaju, Brazil), and to compare the findings with epidemiological data from different geographic locations
In a 10-year period [2006-2016], there were 588 salivary gland neoplasms diagnosed at the 4 pathology reference centers in Aracaju, Sergipe State, Brazil

Summary

Introduction

Introduction of experienceImmunohistochemical and histochemical analyses were performed when routine staining (hematoxylin-eosin) was not sufficient to establish the final diagnosis. - AnalysisDescriptive and quantitative data analysis was performed using the Statistical Package for the SocialSciences for Windows 20.0 (SPSS, Inc., Chicago, IL, USA). Descriptive and quantitative data analysis was performed using the Statistical Package for the Social. Continuous variables were expressed as mean, median and standard deviation values. Categorical variables were expressed as absolute number of cases and percentage values. Salivary gland tumors (SGT) are uncommon lesions that present a wide variation in relation to the clinical, histological, and biological aspects [1,2]. These lesions often represent a diagnostic challenge for the pathologist due to the overlapping of morphological findings [2,3]. Salivary gland tumors (SGT) correspond to a heterogeneous group of lesions with variable biological behavior. The present study aimed to determine the distribution and demographic findings of salivary gland neoplasms in a northeast Brazilian population

Objectives

Results

Conclusion