Case Of Optic Neuritis Research Articles

Electroencephalographic changes in childhood optic neuritis

The EEG changes in acute optic neuritis in children are described. The EEGs are essentially normal in unilateral cases of optic neuritis. In contrast, bilateral optic neuritis with significant visual deficit produced occipital slowing, at times appearing very rapidly. The slowing correlated with the degree of visual deficit and improved with the improvement of visual acuity. In two cases, permanent visual deficit remained and in these, occipital spikes were superimposed on pre-existing slow waves. These clinical observations are discussed in light of the deafferentation hypothesis proposed from other clinical and experimental data.

Optic neuritis and multiple sclerosis. An epidemiologic study.

Since optic neuritis occurs frequently in multiple sclerosis (MS), it has been thought to herald the onset of MS in the young adult where no specific cause can be identified. This study was designed to examine the incidence of optic neuritis in the resident population of Rochester, Minn, in order to clarify the relationship between optic neuritis and MS. Thirteen to fifteen percent of the patients with MS in the Rochester population presented with optic neuritis, and 27% to 37% of the MS patients showed evidence of optic neuritis during the course of their disease. Prospective analysis of idiopathic optic neuritis cases revealed that the chance of its progressing to MS was approximately 17%. The unfavorable prognosis previously associated with idiopathic optic neuritis may be the result of a bias of clinical series.

Peripheral neuropathy after disulfiram administration.

Peripheral neuropathy and optic neuritis occurring in alcoholics are sometimes due to the toxic effects of disulfiram rather than to alcohol. Unless this is considered in the management of such patients it is likely that administration of the drug will be continued. In the past there have been reports of 16 cases of peripheral neuropathy and six cases of optic neuritis, possibly caused in this way; these reports are reviewed and a further six cases are described. The effects of disulfiram on the nervous system are briefly discussed.

Optic Neuritis in Southeast Asia: a Different Pattern of Disease

This review evaluates a number of recent studies on optic neuritis carried out in Singapore. In Singapore, and probably throughout Asia, the disease is more likely to be of the anterior variety with optic disc swelling, and is sometimes associated with an underlying infective process such as syphilis or tuberculosis, or is of an autoimmune aetiology. Most cases of optic neuritis seen in Singapore are idiopathic; multiple sclerosis is rarely seen in the region, but is likely to be found only in patients with retrobulbar optic neuritis. The 4-year risk for patients in Singapore developing multiple sclerosis is only 9.1% compared with the higher figures reported from the seminal Optic Neuritis Treatment Trial. The usefulness of magnetic resonance imaging in the management of optic neuritis in Singapore is reported.

MEGALOBLASTIC ANÆMIA AND VISION

The ocular findings in 19 patients with megaloblastic anæmia are reported. Three reversible abnormalities were found, alone or in combination; haemorrhagic retinopathy, impairment of visual acuity, and disturbance of colour-vision. These changes occurred in folate and vitamin-B 12 deficiencies; their presence was not related to smoking habits and they were found in men and women. The series included a case of optic neuritis of pernicious anaemia in an elderly woman who was a lifelong non-smoker. The other patients did not have the features of optic neuritis; the neurological lesion responsible for the disturbances of vision in these patients does not seem to be identical with that found in tobacco amblyopia.

The treatment of acute optic neuritis. An analysis of eighty cases.

Optic neuritis is a disease for which a precise etiology or pathogenesis is frequently unknown. No specific treatment, accordingly, has received universal acceptance. Nonspecific remedies such as vasodilators, typhoid H antigen, and, more recently, steroids, have all been employed therapeutically. This paper represents an effort to assess the relative merits of the various therapeutic agents heretofore employed in the treatment of acute optic neuritis of unknown etiology and in optic neuritis associated with multiple sclerosis in the hope that such information may serve as a guide to better treatment, or possibly suggest fruitful avenues for future research. The recent literature includes case reports indicating success or failure of treatment with these various agents.1-3In 1952 Carroll4reported on 240 cases of optic neuritis, concluding that no therapeutic agent proved itself superior. Although clinical publications far outnumbered basic scientific contributions in the treatment of optic neuritis, two experimental reports

RETROBULBAR NEURITIS<subtitle>A Complication of Infectious Mononucleosis</subtitle>

IN A REVIEW of the literature, there is a paucity of reports of optic nerve complications associated with infectious mononucleosis reported in children. Since 1931, when Johansen¹and Epstein and Damashek²first reported central nervous system involvement in infectious mononucleosis, there have been few reports of this complication in children. Geliebter,³in 1946, was the first to describe central nervous system involvement in a child. This complication was encephalomyelitis. Recently, Karpinski⁴reported four cases of central nervous system complications of infectious mononucleosis occurring in children. Although cases of optic neuritis,* encephalomyelitis,† and serous meningitis9 as complications of infectious mononucleosis have been reported, we have been unable to find any case of retrobulbar neuritis associated with infectious mononucleosis. Therefore, we feel it is of interest to report the first case of this complication. <h3>REPORT OF A CASE</h3> S. J., a white boy 6 years of age, developed

Retrobulbar neuritis due to cyst of sphenoid sinus.

It seems beyond doubt that retrobulbar neuritis may arise as a result of local, I space-filling or inflammatory lesions. In this connection the aetiological role of ethmoid and sphenoid sinusitis has been a disputed subject. According to Benedict (1933), Lemoine (1938), and Duke-Elder (1940) the reason is the exaggerated enthusiasm with which, despite negative X-ray findings, many cases of retrobulbar neuritis were previously submitted to operations on the nasal sinuses as this was found to improve the condition. It was not remembered that, as Duke-Elder writes, “most of these cases recover spontaneously whether operated on or not, so that if every case were operated upon the cures would be about 90%. Moreover many of the cases thus considered ‘cured’ have developed disseminated sclerosis at a later date… It is rare for cases of optic neuritis to be associated with serious sinus disease.” All authors appear to be agreed on the latter point. Among 225 cases of retrobulbar neuritis Benedict found only one o...

Twelve Cases Of Rhinogenous Optic Neuritis

12 cases of optic neuritis, retinitis, retrobulbar nerve atrophy or punctate superficial keratitis those of which have diagnosed the affection due to nasal disease, amelioration followed on visual aguity with operative treatment of the nasal affection.

OPTIC NEURITIS IN HYPERTHYROIDISM

Edematous and inflammatory diseases of the optic nerves are not always manifestations of a local lesion. In fact, it is known that these nerves, although well protected from direct injury, are often involved by disease processes that are far removed from the eyeball itself. Disease of the optic nerves may be the first indication of extracranial disease. From a review of the literature on the etiology of optic neuritis table 1 has been prepared (Fuchs 1 ). It may not be entirely complete, but it serves to illustrate the many diverse conditions that have been reported as affecting the optic nerves. It is obvious from the multiplicity of the reported causes of optic neuritis that in a given case it is difficult to settle on any one etiologic factor to the satisfactory exclusion of all others. In spite of this, we feel justified in reporting a case of optic neuritis as

A Case of Optic Neuritis Caused by Sphenoidal Sinusitis

A Case of Optic Neuritis Caused by Sphenoidal Sinusitis

A Study of Thirty-six Successive Cases of Optic Neuritis. Nasal Accessory Sinus Disease present Twenty-six Times

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A Study of Thirty-six Successive Cases of Optic Neuritis. Nasal Accessory Sinus Disease present Twenty-six Times

A Study of Thirty-six Successive Cases of Optic Neuritis. Nasal Accessory Sinus Disease present Twenty-six Times

A Study of Thirty-six Successive Cases of Optic Neuritis. Nasal Accessory Sinus Disease Present Twenty-six Times

A Study of Thirty-six Successive Cases of Optic Neuritis. Nasal Accessory Sinus Disease Present Twenty-six Times