Objective Our aim is to report a series of 17 new cases of glandular odontogenic cyst (GOC) diagnosed in a Brazilian laboratory of oral pathology in the last 7 years. Study Design All clinical and radiographic features were retrieved from patients’ charts and the diagnosis of GOC was confirmed after microscopic evaluation following the current World Health Organization (WHO) criteria. Results There were 13 women and 4 men, with a mean age of 46 years. Eleven cases involved the mandible and 6 cases involved the maxilla, particularly the anterior region (10 cases), as extensive well-defined unilocular radiolucencies with limited expansion of bone cortices. The most common histologic criteria observed were eosinophilic cuboidal cells, epithelial detachment, variable thickness, and mucous cells. Most cases were treated by surgical enucleation, with 1 case showing recurrence. Conclusions GOC is an uncommon developmental cyst with features resembling glandular differentiation that may show large size with limited bone expansion.