Cases Of Adenoid Cystic Carcinoma Research Articles

Case of Adenoid Cystic Carcinoma of Lacrimal Gland Treated by Eye Sparing Radiation Therapy using 3DCRT Technique

Case of Adenoid Cystic Carcinoma of Lacrimal Gland Treated by Eye Sparing Radiation Therapy using 3DCRT Technique

PD-L1 and PD-L2 Expression Levels Are Low in Primary and Secondary Adenoid Cystic Carcinomas of the Orbit: Therapeutic Implications.

To determine if there is a biologic rationale for using checkpoint inhibitor drugs targeting programmed cell death ligand 1 (PD-L1) and PD-L2 in the treatment of adenoid cystic carcinoma of the orbit. Twenty-three cases of adenoid cystic carcinoma involving the orbit (13 primary lacrimal gland, 5 secondarily extending into the orbit, and 5 unspecified) were examined histopathologically. Immunohistochemistry for PD-L1, PD-L2, and CD8 was performed. Charts were reviewed for clinical correlations. Expression of PD-L1 and of PD-L2 was overall low in adenoid cystic carcinoma (mean expression 1.4 ± 0.9 of 5 for PD-L1, mean 0.83 ± 1.1 of 5 for PD-L2), and tumor-infiltrating CD8-positive T-lymphocytes were sparse (mean 1.1 ± 0.51 of 3). Only 13 of the 23 (57%) cases expressed PD-L1 as a combined positive score ≥1 of cells. No associations were found between expression levels of these markers and patient sex, tumor site of origin, Tumor, Node, Metastasis stage, or patient outcome. A significant association was observed between stromal PD-L1 expression and tumor histopathologic subtype (p = 0.05), and between tumor PD-L1 expression and prior exposure to radiation (p = 0.03). Checkpoint inhibitor drugs may have limited impact in the treatment and clinical course of orbital adenoid cystic carcinoma based on the low frequency of CD8 infiltrate and low expression of PD-L1 and PD-L2. Pretreatment with radiation, however, may improve tumor response to checkpoint inhibitor drugs.

A Case of Adenoid Cystic Carcinoma of the Mandible Which Responded to Radiation Therapy

A Case of Adenoid Cystic Carcinoma of the Mandible Which Responded to Radiation Therapy

A Case of Adenoid Cystic Carcinoma of the Trachea with a Solitary Lung Metastasis

A Case of Adenoid Cystic Carcinoma of the Trachea with a Solitary Lung Metastasis

An unusual case of adenoid cystic carcinoma of nasal septum mimicking as chronic sinusitis

An unusual case of adenoid cystic carcinoma of nasal septum mimicking as chronic sinusitis

Clinicopathological Features of Adenoid Cystic Carcinoma: An Institutional Perspective

Introduction: Adenoid cystic carcinoma is a rare salivary gland malignancy that can occur in any part of the body, its clinicopathologic features are scarcely reported in locoregional literature. Therefore, in this study we aimed to evaluate the clinicopathologic features of adenoid cystic carcinoma in our population and to determine the association of age and site of its occurrence with histologic pattern and perineural invasion. Methods: We retrospectively analyzed 30 cases of adenoid cystic carcinoma that underwent surgical resections or biopsies from March 2009 to February 2020 at Liaquat National Hospital and Medical College, Karachi. Clinical and histopathological parameters including age, site, histological pattern and perineural invasion were determined and association between different parameters was analyzed. Results: Mean age of the patients was 30 + 16.1 years. Cribriform pattern was most common histologic pattern (63.3%) while head and neck region was the most common site of occurrence (83.3%). Perineural invasion which is one of the most important prognostic factors in adenoid cystic carcinoma was present in approximately half of the patients (46.7%). No significant association of age and site was found with histologic pattern and perineural invasion. Conclusion: Adenoid cystic carcinoma is a rare malignancy most commonly occurring in head and neck region with a high frequency of perineural invasion. No significant difference of histologic pattern and histologic prognostic parameter like perineural invasion was noted at different ages and different sites in our study.

Case report of adenoid cystic carcinoma of the breast – a rare lesion with favorable prognosis

Introduction: Adenoid cystic carcinoma (ACC) is a rare type of breast tumor – less than 0.1% of breast malignancies. Usually, ACC is triple-negative, with lymph node involvement not exceeding 2%, and metastases are uncommon. When localized, the disease is indolent with an excellent prognosis. Objective: To report a case of ACC of the breast and provide data for the medical literature. Method/Case report: J.S.M.S., 44 years old, had a 1 cm nodule in the right breast (RB) and free axillae. Mammography (MMG) showed focal asymmetry in the upper outer quadrant (UOQ) and BI-RADS 0. Ultrasound (US) revealed a solid, circumscribed, periareolar lesion with areas of cystic degeneration, 1.2 cm, BI-RADS 3. Fine-needle aspiration biopsy (FNAB) suggested fibroadenoma. Lesion resection led to the diagnosis of ACC, histological grade 1 (HG1), nuclear grade 1 (NG1), with associated ductal carcinoma in situ (DCIS), and sentinel lymph node with no neoplasia. Immunohistochemistry (IHC) revealed estrogen receptor-negative (ER-), progesterone receptor-negative (PR-), HER2 negative (HER2-), and Ki67 10%. Staging had no evidence of distant disease. The patient did not receive chemotherapy (CT) but underwent 18 sessions of radiotherapy (RT) in the breast with a boost to the tumor bed. She remains disease-free at 8 months of follow-up. Results/Discussion: ACC has low malignant potential with histology similar to that of primary ACC of the salivary gland (which is aggressive); in the breast, it represents 0.058% of all ACC cases. It is more common in Caucasian women aged 60 to 70 years and usually subareolar (approximately 50% of cases). Imaging tests are nonspecific. ACC has lymph node involvement in about 2% of cases. Histology shows epithelial and myoepithelial cells distributed in the classic tubular or cribriform architecture. IHC reveals epithelial cells positive for CD117 and myoepithelial cells positive for smooth muscle actin, calponin, and p63. ACC of the breast expresses proto-oncogene c-KIT and a chromosomal translocation similar to its salivary counterpart: t (6; 9) (q22-23; p23-24). Treatment consists of surgery with free margins. Axillary dissection, CT, and RT have a questionable role due to the indolent course of the disease. Until now, small studies have not suggested a benefit in overall survival when adding adjuvant CT. Although triple-negative, its prognosis is favorable. Local recurrence is approximately 3–18%, and 10-year survival is above 90%. Conclusion: The rarity of these tumors and their favorable course raise questions about the best treatment for ACC. The benefit of axillary dissection, CT, or RT remains unknown because the prognosis seems very favorable with only surgery, despite its triple-negative status. Further studies are necessary to adopt the optimal strategy for these tumors.

Primary Cutaneous Adenoid Cystic Carcinoma

Adenoid cystic carcinoma is a malignant tumor usually localized in the salivary glands. It can also develop in serous glands such as the breast, main bronchi, uterine cervix, Bartholin's gland of the vulva, prostate gland, and external auditory canal. It is more common in the white race. Most of the primary cutaneous adenoid cystic carcinoma cases occur on the scalp. Despite the high rate of metastasis, longterm survival can be observed because the progression of the disease is slow. Distant organ metastases such as lungs, bone, liver and brain have also been reported in the literature at 40%. Its treatment is wide excision of the lesion and demonstration of tumor negative margin in pathological sampling. In this case report, we wanted to present surgical and oncological treatment to a 65-year-old female patient with lung metastasis diagnosed with adenoid cystic carcinoma on the scalp.

Artificial neural network model to distinguish pleomorphic adenoma from adenoid cystic carcinoma on fine needle aspiration cytology.

To differentiate pleomorphic adenoma (PA) and adenoid cystic carcinoma (ACC) on fine needle aspiration cytology (FNAC) is often challenging to cytologists. In the present study, we tried to make an artificial neural network (ANN) model from the FNAC smears to differentiate PA from ACC. The detailed cytomorphological features were analysed on the FNAC of histopathology proven cases of PA (n = 35) and ACC (n = 33) and enumerated semi-quantitatively by two independent observers. These data were used to make an ANN model to distinguish PA from ACC on FNAC material. We used neuro-intelligence software to build the ANN model. The network architecture was 10-2-1. The heuristic search engine was applied to have this model. We used backpropagation neural network to teach ANN. At least 500 iterations were done to train the model. The efficacy of this ANN model was assessed with the help of the confusion matrix and receiver operating characteristic curve. The data were separated automatically by the software as a training set (n = 48), validation set (n = 10) and test set (n = 10). The ANN model was able to differentiate every case (10/10) of PA and ACC in the final test set. The area under the receiver operating characteristic curve was 1. The currently built ANN model is competent to identify PA and ACC cases on FNAC. Additional parameters and new cases can be incorporated into this open-ended ANN model to make it more robust.

ADENOID CYSTIC CARCINOMA: A CASE REPORT

Adenoid cystic carcinoma is the most common malignant salivary gland tumor in most of the studies. It can affect any salivary gland, but it more commonly involves the minor salivary glands of the palate and the parotid glands, presenting as an asymptomatic slow-growing swelling in middle-aged adults. The aim of this report is to present a case of adenoid cystic carcinoma affecting a 45-year-old female patient that demonstrated a painful swelling on the floor of the mouth. The microscopic analysis revealed a salivary gland neoplasm involving the submandibular gland presenting a cribriform architectural growth pattern with the presence of basaloid and hyperchromatic neoplastic cells. Perineural infiltration was also found. Immunohistochemical positivity for AE1/AE3, CK14, and smooth muscle actin was observed, and a low proliferative index measured by Ki67 expression was seen. The patient was then referred for oncologic treatment and is under follow-up in our department. Support: FAPEMIG Adenoid cystic carcinoma is the most common malignant salivary gland tumor in most of the studies. It can affect any salivary gland, but it more commonly involves the minor salivary glands of the palate and the parotid glands, presenting as an asymptomatic slow-growing swelling in middle-aged adults. The aim of this report is to present a case of adenoid cystic carcinoma affecting a 45-year-old female patient that demonstrated a painful swelling on the floor of the mouth. The microscopic analysis revealed a salivary gland neoplasm involving the submandibular gland presenting a cribriform architectural growth pattern with the presence of basaloid and hyperchromatic neoplastic cells. Perineural infiltration was also found. Immunohistochemical positivity for AE1/AE3, CK14, and smooth muscle actin was observed, and a low proliferative index measured by Ki67 expression was seen. The patient was then referred for oncologic treatment and is under follow-up in our department. Support: FAPEMIG

ASSOCIATION OF THE TUMOR-INFILTRATING LYMPHOCYTES WITH RECURRENCE IN ADENOID CYSTIC CARCINOMA OF SALIVARY GLANDS

Objective Tumor-infiltrating lymphocytes (TIL) participate in antitumor immunity. This study evaluated the relation of CD8+ TIL with clinicopathologic parameters in adenoid cystic carcinoma (ACC) of salivary glands. Study Design Cross-sectional and observational research. The sample consisted of 44 cases of ACC diagnosed between 2008 and 2016 at a reference hospital in oncology. Clinicopathologic parameters were obtained from medical records. Immunohistochemistry was used to identify CD8+ cells in peri- and intratumoral areas. CD8+ TILs were measured semiquantitatively according to Ward et al. (2013): 1 = 20%, 2 = 20%-80%, and 3 = > 80% of stroma and also using cut-off obtained by receiver operating curve considering recurrence as variable outcome (P = .03). Fisher exact test and Mann-Whitney test (P < .05) were used. Results Most of ACCs were classified as score 1 or CD8+ TIL low (n = 31; 70%). The peritumoral CD8+ TIL/mm2 varied from 1.04 to 1891.7 and 1.04 to 86.36 in the intratumoral areas. There was significant association of CD8+ TIL low in both areas with recurrence (P = .02). No evidence of association with the others clinicopathologic parameters was observed. Conclusion The ACC presents a low cytotoxic T lymphocyte infiltrate that has resulted in a greater recurrence of this neoplasia. Support: FAPEG 201710267000510. Tumor-infiltrating lymphocytes (TIL) participate in antitumor immunity. This study evaluated the relation of CD8+ TIL with clinicopathologic parameters in adenoid cystic carcinoma (ACC) of salivary glands. Cross-sectional and observational research. The sample consisted of 44 cases of ACC diagnosed between 2008 and 2016 at a reference hospital in oncology. Clinicopathologic parameters were obtained from medical records. Immunohistochemistry was used to identify CD8+ cells in peri- and intratumoral areas. CD8+ TILs were measured semiquantitatively according to Ward et al. (2013): 1 = 20%, 2 = 20%-80%, and 3 = > 80% of stroma and also using cut-off obtained by receiver operating curve considering recurrence as variable outcome (P = .03). Fisher exact test and Mann-Whitney test (P < .05) were used. Most of ACCs were classified as score 1 or CD8+ TIL low (n = 31; 70%). The peritumoral CD8+ TIL/mm2 varied from 1.04 to 1891.7 and 1.04 to 86.36 in the intratumoral areas. There was significant association of CD8+ TIL low in both areas with recurrence (P = .02). No evidence of association with the others clinicopathologic parameters was observed. The ACC presents a low cytotoxic T lymphocyte infiltrate that has resulted in a greater recurrence of this neoplasia. Support: FAPEG 201710267000510.

ADENOID CYSTIC CARCINOMA OF SALIVARY GLANDS: CLINICOPATHOLOGIC ANALYSIS OF 44 CASES

Objectives To evaluate clinicopathologic parameters of adenoid cystic carcinoma (ACC) of salivary glands. Study Design Cross-sectional and observational research. The sample consisted of 44 cases of ACC diagnosed between 2008 and 2016 at a reference hospital in oncology. Clinical parameters (age, sex, anatomic site, tumor size, locoregional metastasis, distant metastasis, clinical staging, recurrence, and survival) were obtained from medical records. Morphologic classification was performed according to Szanto et al. (1984) (cribriform, tubular, and solid) and Weert et al. (2015) (solid/nonsolid). Results ACC represented 8.2% (n = 44) of 531 salivary gland tumors. Mean age of the patients was 53 years. ACC was more frequent in women (n = 29; 59%), major salivary glands (n = 26; 59.1%), and advanced clinical stages III/IV (n = 30; 68.2%). Cribriform (n = 30; 71.4%) and nonsolid (n = 39; 88.6%) pattern were the most frequent. Index of ACC without recurrence was higher (n = 32; 72.7%). Locoregional and distant metastasis occurred in 34% (n = 15) and 13.6% (n = 6) of patients, respectively. Overall survival was ± 42.7 months. Conclusions It is possible to observe that ACC is a very rare and aggressive malignant neoplasia, being diagnosed in advanced clinical stages and with global survival around 5 years. Support: FAPEG 201710267000510.

MASS SPECTROMETRY-BASED PROTEOME PROFILE DIFFERENTIATES ADENOID CYSTIC CARCINOMA FROM POLYMORPHOUS ADENOCARCINOMA

Objective To determine the proteome profile of adenoid cystic carcinoma (AdCC) and polymorphous adenocarcinoma (PAc) and to identify a protein signature useful to differentiate both neoplasms. Study Design Ten cases of AdCC and 10 cases of PAc were retrospectively retrieved and submitted to laser microdissection for enrichment of neoplastic tissue. The samples were submitted to liquid chromatography-tandem mass spectrometry (LC-MS/MS) and the proteomics data were analyzed using the MaxQuant software. MS/MS spectra were searched against the Human UniProt database, whereas statistical analyses were performed with Perseus software. Results The LC-MS/MS analysis identified 1957 proteins. Among these, 261 proteins were exclusively identified in AdCC and 106 proteins only in PAc. Clustering analysis of the 394 statistically significant proteins identified in both tumors showed a clear separation of the tumors. A total of 16 proteins were upregulated in each tumor, 6 in AdCC and 10 in PAc, and their cluster analysis also revealed clear differences between both neoplasms. Conclusions Global proteome can effectively discriminate AdCC and PAc, and the use of a protein signature may represent a useful diagnostic auxiliary to differentiate both tumors in difficult cases. Support: FAPESP 2015/16056-0 and FAPEMIG. To determine the proteome profile of adenoid cystic carcinoma (AdCC) and polymorphous adenocarcinoma (PAc) and to identify a protein signature useful to differentiate both neoplasms. Ten cases of AdCC and 10 cases of PAc were retrospectively retrieved and submitted to laser microdissection for enrichment of neoplastic tissue. The samples were submitted to liquid chromatography-tandem mass spectrometry (LC-MS/MS) and the proteomics data were analyzed using the MaxQuant software. MS/MS spectra were searched against the Human UniProt database, whereas statistical analyses were performed with Perseus software. The LC-MS/MS analysis identified 1957 proteins. Among these, 261 proteins were exclusively identified in AdCC and 106 proteins only in PAc. Clustering analysis of the 394 statistically significant proteins identified in both tumors showed a clear separation of the tumors. A total of 16 proteins were upregulated in each tumor, 6 in AdCC and 10 in PAc, and their cluster analysis also revealed clear differences between both neoplasms. Global proteome can effectively discriminate AdCC and PAc, and the use of a protein signature may represent a useful diagnostic auxiliary to differentiate both tumors in difficult cases. Support: FAPESP 2015/16056-0 and FAPEMIG.

Clinicopathological features of lung salivary gland-type tumors

Objective: To study the clinicopathological characteristics of lung salivary gland-type tumors (SGT), and to compare with the corresponding primary SGT in salivary glands. Methods: Twenty-three cases of lung SGT were retrieved from the files of Peking University First Hospital from January 2004 to September 2018. The morphology, immunophenotype, genotype and outcome of these cases were analyzed. Results: The 23 patients included 13 males and 10 females, with age range of 13-79 years (median 54 years). There were 11 cases of adenoid cystic carcinoma, 10 cases of mucoepidermoid carcinoma (MEC), one case each of clear cell carcinoma and myoepithelioma. The morphology and immunophenotype of lung SGT were very similar to their counterparts in salivary gland. MYB rearrangement was detected in one of 11 adenoid cystic carcinomas. MAML2 rearrangement was detected in all the MECs. EWSR1 rearrangement was detected in the one case of clear cell carcinoma. Of patients with adenoid cystic carcinoma, the survival time was more than 60 months (three cases), 52 months (one case), and 12-36 months (three cases). There was no recurrence and death in seven cases of MEC with follow-up results. One case of clear cell carcinoma recurred after 52 months of follow-up. Conclusions: Although the SGT of lung and their counterparts in salivary gland are very similar in their morphology, immunophenotype, genotype and prognosis, there are also some differences between each other. MYB rearrangement can be detected in most adenoid cystic carcinomas of salivary gland, but rarely in lung adenoid cystic carcinoma. The prognosis of patients with lung MEC is better than that of patients with salivary gland MEC, while the prognosis of patients with lung adenoid cystic carcinoma is worse than that of patients with salivary gland adenoid cystic carcinoma.

Chimeric perforator flap based on the descending branch of lateral circumflex femoral artery for tongue reconstruction after advanced tongue cancer resection

Objective: To explore the advantages and clinical efficacy of free chimeric perforator flap based on the descending branch of circumflex femoral artery applied to tongue reconstruction after advanced tongue cancer resection. Methods: From October 2013 to December 2018, 57 cases received tongue and oral base reconstruction surgeries using the descending branch of circumflex femoral artery chimeric perforator flap, including 39 males and 18 females, ranged from 20 to 76 years old. And all cases were with stage T3 and T4 tongue cancers, including 35 cases of squamous cell carcinoma, 7 cases of low differentiation cancer, 5 cases of oncosarcoma, and 10 cases of adenoid cystic carcinoma. The tongue was reconstructed by using perforator flap and muscle flap to fill the dead space at the oral floor. The artery anastomoses with the superior thyroid artery or facial artery in the receiving area, and the vein anastomoses with the internal jugular vein in the receiving area. The shape, function and local complications of the reconstructed tongue were observed after operation. Results: Of 57 cases, only one case had partial necrosis of flap, while other 56 cases with chimeric perforator flap survived. Postoperative gastric tube and tracheal cannula were removed in all patients, no cases with oral fistula. All donor sites were sutured in one stage. Postoperative radiotherapy was performed in 41 of the patients. All patients were followed up for 3 to 60 months (average of 20.7 months), with satisfactory esthetic and functional results in reconstructed tongues. Only linear scars were left in the donor areas of the legs, and no lower limb dysfunction was observed. Conclusions: The descending branch of circumflex femoral artery chimeric perforator flap can used for repairing simultaneously the defects of both tongue and oral base. It is helpful to avoid the occurrence of oral fistula and to provide the reconstructed tongue with a good function. It is a good choice to use the descending branch of circumflex femoral artery chimeric perforator flap for tongue reconstruction after resection of advanced tongue cancer resection.

외이도에 발생한 선양낭성암종 1예

Adenoid cystic carcinoma (ACC) is thought as a tumor usually found in salivary gland and it is hard to find in external auditory canal. ACC has a slow progression feature and few early symptoms so it is not easy to diagnosis in early stage. ACC is often involved perineural invasion but hardly found in lymph node metastasis. Because of these features, patients with ACC have symptoms such as otalgia, otorrhea and ear canal mass. ACC has 3 different histologic patterns and each patterns have different prognosis. The treatment of ACC is nowdays surgery and postoperative radiotherapy. We report a ACC case in ear canal with a review of other literatures. (J Clinical Otolaryngol 2019;30:232-236)

Utility of p63 and p40 in Distinguishing Polymorphous Adenocarcinoma and Adenoid Cystic Carcinoma.

Objective:Adenoid cystic carcinoma and polymorphous adenocarcinoma are primarily the tumor of minor salivary glands. Both show certain morphological similarities, which limit their proper diagnosis in settings where there are obscuring factors and limited biopsy material. However, there is a considerable difference in treatment and prognosis, which raises the need to distinguish these two entities. In this study, we discuss the utility of two immunohistochemical stains, p63 and p40, in different combinations for distinguishing polymorphous adenocarcinoma from adenoid cystic carcinoma. Materials and Methods:Two immunohistochemical stains, p63 and p40, were performed on 47 cases of adenoid cystic carcinoma and 23 cases of polymorphous adenocarcinoma. Results:36 out of 47 cases of adenoid cystic carcinoma showed p63+ve/p40+ve immunoprofile, followed by p63-ve/p40-ve immunoprofile, which is seen in10 cases of adenoid cystic carcinoma. However, 22 out of 23 cases of polymorphous adenocarcinoma displayed p63+ve/p40-ve immunoprofile. p63-ve/p40+ve is the least frequent observed immunoprofile, which is seen in only one case of adenoid cystic carcinoma. Conclusion:On combining all possible immunoprofile combinations, p63+ve/p40-ve immunoprofile appears to be the most sensitive profile for distinguishing polymorphous adenocarcinoma from adenoid cystic carcinoma.

Mass spectrometry–based proteome profile may be useful to differentiate adenoid cystic carcinoma from polymorphous adenocarcinoma of salivary glands

The aim of this study was to determine the proteome of adenoid cystic carcinoma (AdCC) and polymorphous adenocarcinoma (PAc) and to identify a protein signature useful in distinguishing these two neoplasms. Ten cases of AdCC and 10 cases of PAc were microdissected for enrichment of neoplastic tissue. The samples were submitted to liquid chromatography-tandem mass spectrometry (LC-MS/MS), and the proteomics data were analyzed by using the MaxQuant software. LC-MS/MS spectra were searched against the Human UniProt database, and statistical analyses were performed with Perseus software. Bioinformatic analyses were performed by using discovery-based proteomic data on both tumors. LC-MS/MS analysis identified 1957 proteins. The tumors shared 1590 proteins, and 261 were exclusively identified in AdCC and 106 in PAc. Clustering analysis of the statistically significant proteins clearly separated AdCC from PAc. Protein expression 10 times higher in one group than in the other led to a signature of 16 proteins-6 upregulated in AdCC and 10 in PAc. A new clustering analysis showed reverse regulation and also differentiated both tumors. Global proteomics may be useful in discriminating these two malignant salivary neoplasms that frequently show clinical and microscopic overlaps, but additional validation studies are still necessary to determine the diagnostic potential of the protein signature obtained.

MiR-455-3p, miR-150 and miR-375 are aberrantly expressed in salivary gland adenoid cystic carcinoma and polymorphous adenocarcinoma.

Adenoid cystic carcinoma (AdCC) and polymorphous adenocarcinoma (PAC) are included among the most common salivary gland cancers. They share clinical and histological characteristics, making their diagnosis challenging in specific cases. MicroRNAs (miRNA) are short, non-coding RNA sequences of 19-25 nucleotides in length that are involved in post-transcriptional protein expression. They have been shown to play important roles in neoplastic and non-neoplastic processes and have been suggested as diagnostic and prognostic markers. This study, using quantitative RT-PCR, investigated miR-150, miR-455-3p and miR-375 expression, in order to identify a possible molecular distinction between AdCC and PAC. miRNA-150 and miRNA-375 expression was significantly decreased in AdCC and PAC compared with salivary gland tissue controls, whilst miRNA-455-3p showed significantly increased expression in AdCC when compared to PAC, (P<0.05). miR-150, miR-357 and miR-455-3p expression in AdCC, PAC and control was not associated with age, gender nor with anatomic site (major and minor salivary glands) (P>0.05). MiR-455-3p could be used as a complimentary tool in the diagnosis of challenging AdCC cases.

Histopathological study of adenoid cystic carcinoma in lacrimal gland

Introduction: The lacrimal gland is secretory gland situated in the lacrimal gland fossa. Adenoid cystic carcinoma of lacrimal gland is most common malignant tumor of lacrimal gland and very crucial to differentiate between adenocystic carcinoma and pleomorphic adenoma of lacrimal gland because of different outcome. Aims and Objectives: To study the incidence, histopathological pattern, and distribution into the age, sex of Adenoid cystic carcinoma in to the lacrimal gland. Materials and Methods: A Retrospective study of 14 cases of Adenoid cystic carcinoma in lacrimal gland during period of 10 years were studied A detailed history of patients were taken with special attention to the age, sex, macroscopic (gross examination) and microscopic features of tissue. Microscopic examination is done under standard H & E staining procedure. Result and Conclusion: Total 57 cases of lacrimal gland tumor were studied among them 14 cases of adenoid cystic carcinoma, its most common malignant tumor of lacrimal gland. It’s most common age for presentation is 4th to 6th decade, and most common histological pattern present in mixed pattern. And its incidence are slightly more common in female. Other detail discussed in to the result and discussion section. Keywords: Adenoid cystic carcinoma, Lacrimal gland, Histological patterns, Age, Sex.