Abstract

Adenoid cystic carcinoma is the most common malignant salivary gland tumor in most of the studies. It can affect any salivary gland, but it more commonly involves the minor salivary glands of the palate and the parotid glands, presenting as an asymptomatic slow-growing swelling in middle-aged adults. The aim of this report is to present a case of adenoid cystic carcinoma affecting a 45-year-old female patient that demonstrated a painful swelling on the floor of the mouth. The microscopic analysis revealed a salivary gland neoplasm involving the submandibular gland presenting a cribriform architectural growth pattern with the presence of basaloid and hyperchromatic neoplastic cells. Perineural infiltration was also found. Immunohistochemical positivity for AE1/AE3, CK14, and smooth muscle actin was observed, and a low proliferative index measured by Ki67 expression was seen. The patient was then referred for oncologic treatment and is under follow-up in our department. Support: FAPEMIG Adenoid cystic carcinoma is the most common malignant salivary gland tumor in most of the studies. It can affect any salivary gland, but it more commonly involves the minor salivary glands of the palate and the parotid glands, presenting as an asymptomatic slow-growing swelling in middle-aged adults. The aim of this report is to present a case of adenoid cystic carcinoma affecting a 45-year-old female patient that demonstrated a painful swelling on the floor of the mouth. The microscopic analysis revealed a salivary gland neoplasm involving the submandibular gland presenting a cribriform architectural growth pattern with the presence of basaloid and hyperchromatic neoplastic cells. Perineural infiltration was also found. Immunohistochemical positivity for AE1/AE3, CK14, and smooth muscle actin was observed, and a low proliferative index measured by Ki67 expression was seen. The patient was then referred for oncologic treatment and is under follow-up in our department. Support: FAPEMIG

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