Vaccination subsidy is one of the most important measures to increase the willingness of people to be vaccinated for epidemic prevention and control. Given the budget constraint of vaccination subsidy and the different roles of various age groups population in the epidemic transmission process, a novel approach is proposed to optimize the utilization of the limited vaccination subsidy budget. First, an age-structured SIR model that integrates the human interpersonal contact pattern and vaccine protection effect is developed to simulate the epidemic trend under a certain vaccination state. Then, a decision model is constructed to determine the optimal vaccination subsidy allocation scheme for various age groups based on the age-structured SIR model. A case study of Wuhan City is used to verify the decision approach, and a series of sensitivity analyses are conducted. The result shows that the peak time of an epidemic is positively related to the total treatment cost for all the infections, and more subsidies should be allocated to the populations with higher interpersonal contact frequencies for epidemic prevention and control.
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