This paper describes a method for predicting air temperatures within the Urban Heat Island at discreet locations based on input data from one meteorological station for the time the prediction is required and historic measured air temperatures within the city. It uses London as a case-study to describe the method and its applications. The prediction model is based on Artificial Neural Network (ANN) modelling and it is termed the London Site Specific Air Temperature (LSSAT) predictor. The temporal and spatial validity of the model was tested using data measured 8 years later from the original dataset; it was found that site specific hourly air temperature prediction provides acceptable accuracy and improves considerably for average monthly values. It thus is a very reliable tool for use as part of the process of predicting heating and cooling loads for urban buildings. This is illustrated by the computation of Heating Degree Days (HDD) and Cooling Degree Hours (CDH) for a West–East Transect within London. The described method could be used for any city for which historic hourly air temperatures are available for a number of locations; for example air pollution measuring sites, common in many cities, typically measure air temperature on an hourly basis.