A case report of a boy, 18 years of age, with an intrauterine historyof chronic illness on the part of the mother and a diet definitely deficient in minerals and vitamins during the first few years of life, is presented. There was advanced clinical rickets at 2 years of age associated with a moderate enlargement of the liver. No specific therapy was given until the child was 9 years old, when he was sent to the country for the summer and a marked improvement in walking ability followed extensive exposure to sunshine. At 18 years of age metabolism studies showed a dyscrasia in calciumand phosphorus metabolism which has been described in detail. Death occurred at 19 years from pulmonary tuberculosis. Necropsy observations which were pertinent to the case history showedthat the dentine of the teeth was riddled with interglobular spaces and that the enamel was very hypoplastic. The bones showed a definite thinning of the cortex and the red marrow was hyperplastic. The two parathyroid glands which were isolated were normal, grossly and histologically. The lived displayed advanced portal cirrhosis. A case report of a boy, 18 years of age, with an intrauterine historyof chronic illness on the part of the mother and a diet definitely deficient in minerals and vitamins during the first few years of life, is presented. There was advanced clinical rickets at 2 years of age associated with a moderate enlargement of the liver. No specific therapy was given until the child was 9 years old, when he was sent to the country for the summer and a marked improvement in walking ability followed extensive exposure to sunshine. At 18 years of age metabolism studies showed a dyscrasia in calciumand phosphorus metabolism which has been described in detail. Death occurred at 19 years from pulmonary tuberculosis. Necropsy observations which were pertinent to the case history showedthat the dentine of the teeth was riddled with interglobular spaces and that the enamel was very hypoplastic. The bones showed a definite thinning of the cortex and the red marrow was hyperplastic. The two parathyroid glands which were isolated were normal, grossly and histologically. The lived displayed advanced portal cirrhosis.