Objective: To explore the medical imaging features of lung cancer brain metastases, and to explore the application effect of health informatics process reengineering on nursing management. Methods: Retrospective analysis of the medical data of patients admitted, including the number of cases of nosocomial infections in the two years, and analysis and summary of the reasons for the hospital patients were divided into the control group and the observation group. The control group was treated with traditional care, and the observation group was re-engineered in the basic upward process of the control group. The nursing quality scores, the occurrence of nursing errors and the satisfaction of nursing were compared between the two groups. Results: The nursing quality score of the observation group was better than that of the control group. The incidence of nursing errors was lower than that of the control group. The patient’s nursing satisfaction was higher than that of the control group (P > 0.05). Conclusion: The implementation of process reengineering in nursing management can effectively improve the quality of indoor nursing work, reduce the incidence of error events in the nursing work process, and improve the satisfaction of patients and their families.