Case Of Malignant Chondroid Syringoma Research Articles

Giant malignant Chondroid Syringoma: Case Report and Literature Review

Chondroitin syringoma, also known as cutaneous mixed tumor, is a rare type of sweat gland tumor, accounting for 0.01% to 0.1% of all primary tumors of the skin. The malignant form is extremely rare, with 41 cases described so far. It predominates in the trunk and distal extremities and affects women more frequently, with a 3: 2 rate 6,7. Patients may reach the health service with large lesions due to the fact of being slow-growing lesions and have a high rate of recurrence, requiring surgical treatment that may lead to extensive defects making complex reconstructions necessary. We present a case of malignant chondroid syringoma in an 80 years old male patient, with 29 years of evolution and unusual size. A reconstruction was performed with a muscular dorsal flap of the latissimus dorsi with good aesthetic and functional results, with no signs of recurrence after 8 months of follow-up. It is concluded that because it is a late diagnosis neoplasia, the surgical treatment ends up generating expressive defects. There for musculocutaneous should be considered as an option for reconstruction, aiming optimal functional and aesthetic restoration.

Multifocal, recurrent malignant chondroid syringoma with visceral metastases: A case report and literature review

We present the unusual case of malignant chondroid syringoma (MCS) in a 64-year-old male with recurrent nodular skin lesions and visceral metastases. The patient underwent repeated excisions, with eventual development of widespread nodules and multiple pulmonary and hepatic nodules. Systemic chemotherapy was planned. MCS is a very rare skin adnexal tumor of the sweat glands with only around 50 cases reported worldwide. To the authors’ knowledge, this is the first reported case of MCS with a multifocal presentation and mucosal involvement.

English

Malignant chondroid syringomas (MCS), which are also called malignant mixed tumors of the skin, are extremely uncommon tumor arising from the eccrine sweat glands with tumor differentiation in the epithelial and mesenchymal tissues. Malignant chondroid syringomas commonly involve the limbs, head and neck rarely trunk. In this article, we present a case of malignant chondroid syringoma localized in the anterior abdominal wall. Wide local excision was followed by close observation. After 3 years of close observation the patient remains asymptomatic.MCS is rare with 43 reported cases in the literature. The site of the primary tumor was the lower extremity in 35 percent, the head in 28 percent, and the upper extremity in 23 percent .As MCS may progress very slowly and disease recurrence including metastasis occurs in a relatively high percentage of cases, long-term follow-up of MCS cases is required.

Malignant Chondroid Syringoma of the Face With Bone Invasion

Malignant chondroid syringoma is a very rare type of malignant sweat gland tumor. Diagnosis is based on pathologic features but is complicated by the low frequency of this tumor. The authors report a new case of malignant chondroid syringoma, initially misdiagnosed as basal cell carcinoma, that exhibited very aggressive local behavior and was located on the face, a rare site for this tumor. The authors describe its histopathologic appearance and highlight the importance of including adenoid cystic carcinoma in the differential diagnosis.

Facial Localization of Malignant Chondroid Syringoma: A Rare Case Report

First described by Hirsch and Helwig in 1961, chondroid syringomas (CSs) are rare, benign tumors of the skin arising from the eccrine sweat glands with tumor differentiation in the epithelial and mesenchymal tissues. They most commonly occur in the head and neck, although they may be also found in the axilla, trunk, limbs, and genitalia. The incidence of CS is <0.01% of all primary skin tumors. Malingnant chondroid syringomas (MCS), which are also called malignant mixed tumors of the skin, are extremely uncommon. MCSs commonly involve the limbs and rarely head and neck. In this article, we present a case of malignant chondroid syringoma localized in the face at the left nasolabial region in the light of literature review.

悪性軟骨様汗腺腫（悪性混合腫よう）（原標題は英語）

We report a case of malignant chondroid syringoma affecting the preauricular portion of the left ear of a 67-year-old man. There were submental lymph node metastasis and multiple pulmonary metastases two months later. The local recurrence occurred at the primary site about 12 months after the initial insufficient surgical procedure. We suspected clinically squamous cell carcinoma was suspected. However, the findings of the histopathological, immunohistochemical and ultrastructual examinations for reccurent tumor led us finally to make a diagnosis of malignant chondroid syringoma. Patient received electron beam radiation followed by administration of chemotherapeutic agents including CDDP, 5-FU and irinotecan and taxotere. We discussed the usefulness of such combination therapy, particulary the chemotherapeutic agents including taxotere.

A rare adnexal tumour of the hallux: malignant chondroid syringoma

We report a case of malignant chondroid syringoma, a rare sweat-gland tumour with a propensity to occur on the extremities. These tumours must be distinguished histologically from their benign counterpart and from other malignancies with mixed epithelial and mesenchymal components. The malignant chondroid syringoma arises in the dermis or superficial subcutis and consists of eccrine or apocrine glandular epithelium, often showing mitotic activity and nuclear pleomorphism, within a benign-looking chondromyxoid stroma. It is locally infiltrative, with a tendency to local recurrence and metastasis. When the diagnosis is made histologically, clinical evidence of metastases should be sought. In the absence of metastatic disease local excision is curative.

Malignant chondroid syringcma of the thigh. Report of a case with electron microscopy of the tumour

A case of malignant chondroid syringoma occurring in a 52-year-old female is reported. The tumour presented as a large, cystic lesion of the thigh. Local recurrence and secondary deposits in the inguinal region occurred at an early stage. The rarity of these malignant tumours and metastasising sweat gland tumours in general is emphasised.