Abstract
We present the unusual case of malignant chondroid syringoma (MCS) in a 64-year-old male with recurrent nodular skin lesions and visceral metastases. The patient underwent repeated excisions, with eventual development of widespread nodules and multiple pulmonary and hepatic nodules. Systemic chemotherapy was planned. MCS is a very rare skin adnexal tumor of the sweat glands with only around 50 cases reported worldwide. To the authors’ knowledge, this is the first reported case of MCS with a multifocal presentation and mucosal involvement.
Highlights
Skin cancer causes significant morbidity worldwide.[1]
Apocrine-eccrine carcinomas are rare, with a reported incidence rate of 2.6 per 1 million personyears. These adnexal neoplasms are associated with a prolonged course and a poor prognosis in the presence of metastatic disease, with a 5-year relative survival rate of 51%
Due to the absence of a distinct clinical presentation, it is difficult to distinguish from other cutaneous tumors.[4] scattered plasmacytoid myoepithelial cells
Summary
Skin cancer causes significant morbidity worldwide.[1] apocrine-eccrine carcinomas are rare, with a reported incidence rate of 2.6 per 1 million personyears. Still, these adnexal neoplasms are associated with a prolonged course and a poor prognosis in the presence of metastatic disease, with a 5-year relative survival rate of 51%.2,3. Malignant chondroid syringoma (MCS), called malignant mixed tumor of the skin, is an extremely uncommon eccrine sweat gland neoplasm with epithelial and mesenchymal components. Due to the absence of a distinct clinical presentation, it is difficult to distinguish from other cutaneous tumors.[4] scattered plasmacytoid myoepithelial cells (see Figure 1). The final histopathologic diagnosis was malignant chondroid syringoma.
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