Case Of Fibroadenoma Research Articles

Juvenile fibroadenoma with features of phyllodes tumor showing intraductal growth and prominent epithelial hyperplasia in an 11-year-old girl

Breast tumors in children are uncommon, with the majority of them being adult-type fibroadenoma (FA). We report a case of juvenile FA (JFA) with features of a benign phyllodes tumor (PT) in an 11-year-old girl, showing very unusual intraductal/intracystic growth. The tumor was located at the outer peripheral portion of the right breast apart from the nipple. Histologically, the tumor showed extensive leaf-like papillary structures with a broad fibrous stroma, protruding into multiple contiguous cystic spaces lined by flat ductal epithelium, and closely resembled PT but the stroma of the tumor was only slightly cellular, showing no nuclear atypia and very few mitotic figures. In contrast, epithelial cells covering the fronds exhibited marked hyperplasia, forming a thick multilayered epithelium. The histology of the tumor with intracystic papillary structures and epithelial hyperplasia showed some similarities with intraductal papilloma (IDP). The mechanism of such unusual intraductal growth of fibroepithelial tumors, including FA/JFA and PT, and their possible common histogenesis with IDP are discussed.

妊娠期に急速増大した乳腺線維腺腫（15cm）の1例

症例は30歳，女性．2010年6月，左乳房に2.5cm大の腫瘤を自覚し近医を受診．吸引式乳房組織生検（VAB）で管周囲型線維腺腫と診断し経過観察した．1カ月後に妊娠し，腫瘍の増大を認めたが妊娠によるものと判断し経過観察した．妊娠8カ月に15cm大に増大したため，再度VABを施行．良性の増殖性病変と診断したが，急速増大していることから葉状腫瘍も否定できず，手術目的に当院紹介となった．左乳房外側上方を中心に15cmの腫瘍を認め，乳腺エコーで境界明瞭平滑，内部不均一な腫瘤，MRIでは境界明瞭で乳腺組織を内尾側に圧排する分葉状腫瘤を認め，T2強調像で腫瘤の内部が不均一で変性が強いことより葉状腫瘍を疑った．妊娠週齢を考慮し，32週に全身麻酔下に腫瘍摘出術を施行した．病理組織学的検査では管周囲型線維腺腫であった．今回われわれは，妊娠期に急速増大した繊維腺腫の1例を経験したので若干の文献的考察を含め報告する．

Fibroadenoma of ectopic breast of axilla: A rare case report

Ectopic breast tissue (EBT) is a rare anomaly. Common location of EBT is along the milk line extending from the nipple to the symphysis pubis. EBT is susceptible to same pathologic processes as normal breast. Fibroadenoma though very frequent entity, but is very rarely reported in EBT of axilla. It poses a diagnostic challenge to the treating physician, and high index of suspicion is required for early detection. Here we report a rare case of fibroadenoma of EBT of axilla in a 25-year-old girl, which was managed by excision.

Bilateral fibroadenoma of the ectopic breast tissue in axilla: A case report

Anomalies associated with breast development are common, presenting as supernumerary nipples (polythelia) and less often as supernumerary breast (polymastia) in 1–5% of population. These anomalies are more common in women and also most frequently located along the mammary line, extending from the axilla to pubic region. The axillary polymastia is the most common variant of ectopic breast tissue (EBT). EBTcan undergo the same physiological and pathological processes as the normal breast. The incidence of fibroadenoma developing in ectopic breast is a rare entity, most common being the carcinoma. We report here a case of fibroadenoma of EBT in both axillae of a 33-year-old Asian woman. This case has been reported for its rarity and to reemphasize the importance of screening of EBT for any pathology during routine screening of breast.

Intraductal fibroadenoma under the nipple in an 11-year-old female

Recently, Chung et al. have reported the detailed clinicopathological features of an extremely rare case sharing similar histopathological characteristics with fibroadenomas, phyllodes tumours, intraductal papillomas or ductal adenomas, given the name of intraductal fibroadenomatosis, as an unusual variant of intracanalicular fibroadenoma. Herein we demonstrated a very unusual case of intraductal fibroadenoma of the breast with admixture of components of intracanalicular type fibroadenoma or benign phyllodes tumour and a smaller amount of intraductal papilloma, occupying the one duct and some adjacent ductules, presenting as a well-demarcated nodule.

Fibroadenoma of axillary ectopic breast tissue: A rare clinical entity

Supernumerary breast or polymastia is a well-documented anomaly of the breast and commonly presents along the embryonic milk line extending between the axilla and groin. Reported incidence of accessory breast is 0.4-6% in females. During 2 years period, we encountered only two cases out of twenty cases of axillary lumps. We present one case of fibroadenoma in ectopic breast tissue (EBT) in axilla. Ectopic breast denotes breast tissue at more than two pectoral regions, which is mostly benign but at times can be malignant. EBT is at a greater risk of malignancy. Fibroadenoma of ectopic axillary breast tissue (EBT) is quiet rare, but should always be kept in mind for differential diagnosis of an axillary mass.

Giant Fibroadenoma of Breast mimicking Phylloides Tumour in an Adolescent Girl: Case Report

We are reporting a rare case of giant fibroadenoma in a 15 year adolescent girl. The provisional diagnosis of the patient was made on FNAC which showed a benign proliferative brest lesion. Total excision of the mass was done preserving nipple and areola. Histopathology features were suggestive of giant fibroadenoma

Juvenile fibroadenoma: a cytology case report

Fibroadenomas are benign breast tumors. These tumors are commonly seen in the age group of 20-30 years. They are very rare in children. Here we are presenting a case of fibroadenoma of the breast in a 10 year old girl. These juvenile fibroadenomas constitute 4% of the fibroadenomas of the breast and comprise 0.5% of the breast tumors, in paediatric age group.

Primary Well Differentiated Breast Liposarcoma with Divergent Cartilagenous Differentiation: A Case Report

Primary liposarcomas of the female and male breasts are very rare. Heterologous differentiation in adipocytic tumors is also an exceedingly rare phenomenon, which is occasionally reported in the literature. We describe the case of a 22 year-old female who presented with a relatively large left breast mass which was clinically diagnosed as a case of giant fibroadenoma, but histologically showed a well differentiated liposarcoma with evidence of extensive chondroid differentiation. The mammographic and radiological features are presented and correlated with the histopathological appearances together with literature review and comparison with similar reported cases.

A Case of Fibroadenoma in Axillary Accessory Breast

A Case of Fibroadenoma in Axillary Accessory Breast

Vulva Fibroadenoma Associated with Lactating Adenoma in a 26-Year-Old Nigerian Female

Background. Vulva lactating adenoma is rare and may be misdiagnosed as adenocarcinoma in frozen section and aspiration cytology if breast tissue is not anticipated. Objective. To raise the awareness of lactating vulva ectopic breast lesion among clinicians and pathologists. Case Report. We present a case of vulva fibroadenoma associated with lactating adenoma in a 26-year-old Nigerian female. Conclusion. The rarity of vulva ectopic breast tissue can present a diagnostic challenge for both the clinician and the anatomical pathologist. Once excisional biopsy is done and the lesion confirmed histologically, the anxious patient can be reassured.

Fibroadenoma in Axillary Supernumerary Breast: Case Report

INTRODUCTION: Supernumerary breast tissue is subject to the same alterations and diseases, whether benign or malignant, that affect normal breast tissue. Since publications describing this anomaly are rare in the literature, we decided to report on a case of fibroadenoma in axillary breast tissue. CASE REPORT: A 34-year-old white female patient was reffered to the mastology clinic at Barao de Lucena Hospital in June 2012. She complained of masses in the axillary region, unilaterally, which were associated with local pain and discomfort, especially during her menstrual periods on physical examination, alterations compatible with unilateral axillary accessory breasts, with palpable nodules, were observed. Supplementary examinations (ultrasonography) revealed a 3. 9 cm mass in the right axillary breast. The paciente underwent a histopathological examination (core biopsy) showed fibroadenoma of the right axillary breast tissue. DISCUSSION: Supernumerary breast tissue is well documented in the medical literature, and polymastia is one of its most common presentations. However, reports of benign and malignant tumors in supernumerary breast are rare. Although the benign nature and natural history of fibroadenoma are well known, biopsy should be considered for women of this age, if conservative management is chosen, periodic clinical and mammographic control is required, following negative cytological tests. The need for careful investigation of supernumerary breast tissue should be emphasized, because it may be affected by benign and malignant diseases.

An Audit Of Open Breast Biopsies In Two Hospitals In The Niger Delta

Context Biopsies provide histological diagnosis and as such may guide subsequent management of breast lumps. Regular audit of such biopsies are necessary to document epidemiological pattern of the histological diagnosis within a population. Objective To review the histological diagnoses of breast biopsies in two referral centres in the Niger Delta region of Nigeria. Methodology This is a descriptive analysis of retrospective data obtained from the Central Hospital Warri and the University of Benin Teaching Hospital, Benin City, all in the Niger-Delta region of Nigeria between 2005 and 2010. Results Data on 367 biopsies were analysed. Patients with benign diagnoses aged in range between 14 and 48 years and those with malignant conditions between 20 and 85 years. Fibroadenoma was the commonest histological diagnosis (36.0%) with a mean age at diagnosis of 22.9 5.5 years. Just one case of fibroadenoma was recorded beyond 36 years. years. Malignancies were seen in 29.4% of biopsies with Invasive ductal carcinoma being the dominant histological type, 89.8%. The mean age at diagnosis of breast cancer was 46.0 12.1 years. Incidence of malignant findings ranged from less than 1 in 10 biopsies below 30 years, 1 in 2 biopsies at the 31-35 years age range to nearly unit in those 56 years and above. Conclusion Fibroadenoma is the commonest breast biopsy finding in the referral centres in the Niger Delta. Breast cancer occurs commonly among premenopausal women.Key words: Breast, Biopsy, Fibroadenoma, Invasive ductal carcinoma.

Diagnosis and management of an unilateral giant fibroadenoma of the breast in pregnancy

Fibroadenomas represent the vast majority of breast pathologies in young women. 2-4% of the fibroadenomas exceed 5cm in size or 500g in weight and are called "giant fibroadenomas". Due to their excessive growth they are usually enucleated to clarify a malignant origin, to differentiate from phyllodes tumor and to prevent persisting deformities of the breast. We present a case of a 17-year-old female who was pregnant in the 24th week and suffered from a giant fibroadenoma in the right breast. Besides the massive swelling no other illnesses were found. The patient was clinically asymptomatic and had noticed the tumor just 8weeks ago. On clinical examination we found a tumor of more than 10cm in size which fulfilled the criteria of a benign process. A prior performed biopsy and an ultrasound investigation could not definitely differentiate the mass from phyllodes tumor. Because of the rapid growth and the progressive deformation of the breast a lumpectomy was indicated and performed without complications in consideration of the gestational stage. We present a rare case of giant fibroadenoma in pregnant young women. Because of the progressive structural damage of the breast immediate surgical enucleation was indicated. Safety of the fetus was provided by perioperative monitoring. The pre-operative differentiation from phyllodes tumor is still challenging.

Fibroadenoma in male breast: Case report and literature review

We report a rare case of mammary fibroadenoma in a 75 year old male patient with emphasis on imaging findings and review of the previously reported cases.

Fibroadenoma of the axillary accessory breast: diagnostic value of dynamic magnetic resonance imaging

Accessory breast is synonymous with polymastia or supernumerary breast tissue. An accessory breast without a nipple or areola is rare. We report a case of fibroadenoma of an accessory breast with no nipple or areola in a 41-year-old woman who presented with a right axillary mass associated with five small nodules in the normally situated breast. Magnetic resonance imaging (MRI) showed the accessory breast surrounding the tumor. We ignored the presence of the component surrounding the mass and made a preoperative diagnosis of an axillary mass of possible metastases from multiple breast cancers or breast cancer of unknown origin associated with multiple breast fibroadenomas. From a retrospective view, based on the histological results, MRI and dynamic MRI demonstrated a tiny component of breast-like tissue surrounding the axillary mass and an enhancement pattern typical of fibroadenoma for the axillary mass. For the later diagnosis of the axillary mass, the interpretation of whether the component of breast tissue surrounding the axillary mass was present is crucial. If the component exists, a tumor that originated from the accessory breast should be foremost in the differential diagnosis. Dynamic MRI appears to contribute to the diagnosis of fibroadenoma of an accessory breast before biopsy or surgical resection.

Fibroadenoma of the ectopic breast of the axilla

Polymastia is a term that is used to describe the presence of more than two breasts in human beings. It is synonymous with supernumerary or accessory breast tissue. Ectopic breast tissue (EBT) may occur any where along the primitive embryonic milk lines, which extend from the axilla to the groin, and may occur unilaterally or bilaterally. In the EBT any disease can develop that affects the normal breast, including fibroadenoma. Since publications describing this anomaly are rare, we decided to report a case of fibroadenoma in axillary breast tissue.

Exuberant Smooth Muscle Cells in Fibroadenoma of the Breast - A Case Report -

Smooth muscle cell metaplasia is an extremely rare form of stromal differentiation in fibroadenomas. We describe a case of fibroadenoma with exuberant smooth muscle cells in a 72year-old woman. The mass was located in the upper central portion of the left breast. It was well circumscribed and its greatest dimension was 3 cm. Histologically, the glandular elements resembled the appearance of fibroadenoma, but the stromal elements were composed of spindle cell bundles with abundant eosinophilic cytoplasm and elongated cigar-shaped nuclei. Neither mitotic activity nor cellular atypia was seen. The stromal cells were immunohistochemically positive for smooth muscle actin, calponin, desmin, and estrogen receptor-b, but negative for CD34, S-100 protein, p63, CD10, estrogen receptor-a, progesterone receptor and cytokeratin. These results proved that the stromal cells showed features of smooth muscle cells.

Evidence for Transformation of Fibroadenoma of the Breast to Malignant Phyllodes Tumor

Fibroadenoma (FA) and phyllodes tumor (PT) of the breast are biphasic tumors composed of variable proportions of epithelial and stromal cells. We identified a case of synchronous FA and PT in the same breast mass. Using laser capture microdissection, loss of heterozygosity analysis was performed on these components to gain potential insight into the histogenetic relationship between FA and PT. Genomic DNA was analyzed at 10 microsatellite loci by polymerase chain reaction. Both tumors showed allelic loss at D7S522. In addition, phylloid tumor showed allelic loss at TP53 and D22S264, not observed in FA. Our data suggest that FA and PT are clonally related and allelic loss at TP53 and D22S264 may be implicated in the progression of FA to phyllode tumor.

Bilateral giant juvenile fibroadenoma of breasts

An 11-year-old girl with rapidly enlarging bilateral breast lumps is reported. It was diagnosed as a case of juvenile fibroadenoma following fine needle aspiration cytology and confirmed on histopathological examination of the excised specimens.