Cases Of Chronic Ulcerative Colitis Research Articles

A Case of Chronic Ulcerative Colitis Developing Eosinophilic Colitis

A Case of Chronic Ulcerative Colitis Developing Eosinophilic Colitis

Point injection for 43 cases of chronic ulcerative colitis

Pishu (BL 20), Dachangshu (BL 25), Zusanli (ST 36), and Shangjuxu (ST 37) were selected to treat chronic ulcerative colonitis in 43 cases by point injection with placental tissue fluid and the curative effect was compared with that of west medicine plus enema in 22 cases (control group). It showed that there was a significant difference in short-term total effective rate between the two groups. It suggested that point therapy was effective.

Chronic ulcerative disease of the colon.

The surgical material from 41 random cases of chronic ulcerative disease of the colon was reviewed. There were 28 cases of chronic ulcerative colitis and 13 cases of Crohn's disease of the colon. The clinical and pathologic findings were in agreement, in general, with those reported in the literature. Specimens from ten cases of chronic ulcerative colitis and five cases of Crohn's disease of the colon were studied with additional special stains. In the former the argentaffin and argyrophilic cells were usually increased in numbers, but in the latter those cells were decreased. In two of the indicated five cases of Crohn's disease the mucosal mucin apparently was inducing the granulomas, which were similar to those reported to occur in the disease.

Carcinoma of the colon following chronic ulcerative colitis: report of two unusual cases in brothers.

Two cases of chronic ulcerative colitis occurring in brothers who ultimately developed cancer of the large bowel are presented. These are the first cases of this kind that the authors have been able to discover in medical literature. The possibility of hereditary predisposition to both ulcerative colitis and cancer is discussed.

The prognosis of chronic ulcerative colitis in children.

THE controversy concerning the treatment for chronic ulcerative colitis has never ended. The question whether surgical or medical management prolongs these patients' lives with greater certainty has never been answered. The problem is particularly difficult in children. Complete colectomy is a formidable procedure, and problems associated with permanent ileostomy are often difficult. There is also the very real hazard that complicating carcinoma may develop, and in addition the survival period from the disease is variable.In 1959 Rosenqvist and his associates1 reported their experience with 150 cases of chronic ulcerative colitis in their pediatric department. They stated that cancer of . . .

Chronic Ulcerative Colitis in a North American Indian

Summary A case of chronic ulcerative colitis in a North American Indian man of the Saulteaux tribe is reported. The disease involved the entire large bowel and resulted in multiple perforations. One of the other 2 cases known to us of ulcerative colitis in North American Indians had a similar outcome.

Chronic perineal sinus following total colectomy for ulcerative colitis

1. 1. Thirty-two cases of chronic ulcerative colitis treated by proctocoletomy are reviewed with special emphasis on the perineal wound. Each case was treated by total colectomy and removal of the rectum in one or more stages. 2. 2. The perineal wound had not healed after more than three months in twenty-seven of these patients. 3. 3. No relationship was found between the rate of healing of the perineal wound and age, use of ACTH and cortisone, presence of perforation of the colon at surgery, specific bacteria, duration of the disease before colectomy or the number of surgical procedures performed to accomplish proctocolectomy. 4. 4. The etiology of the persistent perineal sinus tract is believed to be related to pelvic dead space and obstruction of the perineal outlet. 5. 5. Prevention of the perineal sinus tract can be accomplished by allowing the posterior parietal peritoneum to remain open after resection of the rectum and by wider resection of the levator ani muscles. 6. 6. The treatment of an established sinus tract is by proper drainage of the long tracts and by complete excision of the shorter sinus tracts.

Amyloidosis secondary to chronic ulcerative colitis.

Case Reports1 October 1959AMYLOIDOSIS SECONDARY TO CHRONIC ULCERATIVE COLITISIRVING A. WARREN, M.D., F.A.C.P., ISAIAS STRYGLER, M.D., SIDNEY D. KOBERNICK, M.D., Ph.D.IRVING A. WARREN, M.D., F.A.C.P.Search for more papers by this author, ISAIAS STRYGLER, M.D.Search for more papers by this author, SIDNEY D. KOBERNICK, M.D., Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-4-795 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAmyloidosis secondary to chronic ulcerative colitis is rare, only six cases having been reported in detail. The first was described by Moschcowitz1in 1936. Additional single cases were reported by Mallory2in 1947, Jensen et al.3in 1950, and Frenkel and Groen4in 1954. In 1955 Mandelbaum and Bryk5described two instances in a series of 108 cases of chronic ulcerative colitis autopsied at Mt. Sinai Hospital, New York, over a 20-year period. A few additional cases have also been briefly mentioned or tabulated.6, 7, 8The following case is, we believe, the seventh to be reported in detail of...Bibliography1. Moschcowitz E: The clinical aspects of amyloidosis, Ann. Int. Med. 10: 73, 1936. LinkGoogle Scholar2. MalloryCastlemanRopes TBBMW: Case records of the Massachusetts General Hospital, Case No. 33021, New England J. Med. 236: 75, 1947. MedlineGoogle Scholar3. JensenBargenBaggenstoss EJJAAH: Amyloidosis associated with chronic ulcerative colitis, Gastroenterology 15: 75, 1950. CrossrefMedlineGoogle Scholar4. FrenkelGroen MJ: Amyloidosis na behandling met ACTH, Nederl. tijdschr. v. geneesk. 98: 2357, 1954. Google Scholar5. MandelbaumBryk ID: Idiopathic chronic ulcerative colitis and amyloidosis, J. Mt. Sinai Hosp. 22: 24, 1955. MedlineGoogle Scholar6. Fishberg AM: Hypertension and nephritis, 5th Ed., 1954, Lea & Febiger, Philadelphia, p. 516. Google Scholar7. Dahlin DC: Secondary amyloidosis, Ann. Int. Med. 31: 105, 1949. LinkGoogle Scholar8. KlecknerMagidson MSJ: Amyloidosis of the liver. Correlation of clinical and pathological features, Gastroenterology 29: 56, 1955. CrossrefMedlineGoogle Scholar9. JensenBaggenstossBargen EJAHJA: The kidney in chronic ulcerative colitis, Proc. Staff Meet., Mayo Clin. 25: 244, 1950. Google Scholar10. Rosenblatt MD: Recovery from generalized amyloidosis secondary to pulmonary tuberculosis, Arch. Int. Med. 57: 562, 1936. CrossrefGoogle Scholar11. Pearlman AW: Regression of amyloidosis, Quart. Bull., Sea View Hosp. 6: 92, 1940. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication April 7, 1958.From the Divisions of Medicine and Laboratories, Sinai Hospital and Wayne State University College of Medicine, Detroit, Michigan.Requests for reprints should be addressed to Irving A. Warren, M.D., 4100 West McNichols Road, Detroit, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA fatal case of Reiter's disease complicated by amyloidosisMiscellaneous diseases of the colonAmyloidosisColitis ulcerosaAnkylosing spondylitis with ulcerative colitis and amyloidosisSystemic Amyloidosis and Ulcerative ColitisReferencesAmyloidosisGORDON W. BRIGGS 1 October 1959Volume 51, Issue 4Page: 795-801KeywordsAmyloidosisColitisDiarrheaEdemaFistulasGlomerulonephritisHospital medicineInflammationUlcerative colitis Issue Published: 1 October 1959 PDF downloadLoading ...

Carcinoma in chronic ulcerative colitis; report of a case, with death in six weeks.

A case of chronic ulcerative colitis is reported in which a carcinoma developed 17 years after onset of the disease. The patient was treated with a radical subtotal colectomy and ileostomy. The pathological report confirmed the presence of a 3 cm., well-differentiated carcinoma of the right transverse colon with 59 negative lymph nodes. The patient died six weeks following operation with widespread metastatic disease, confirmed at autopsy. The purpose in again discussing neoplasia in chronic ulcerative colitis is to reiterate the virulence of the cancer, even in the presence of negative lymph nodes; to point out the gravity of shedding viable cancer cells, especially in the presence of a nourishing incubating medium, such as ascitic fluid, and to discuss the remarkable capacity for malignant-cell transplantation of a patient with ulcerative colitis without a spleen. Report of Case A 32-year-old itinerant waiter who had a history of ulcerative colitis for 17

The Liver in Regional Enteritis

Summary Clinical, laboratory and needle biopsy studies of the liver in 20 consecutive cases of regional enteritis disclosed no significant hepatic disease in 17 cases and fatty infiltration of the liver in 3 cases. In contrast, in 32 cases of chronic ulcerative colitis, needle biopsy of the liver and hepatic function tests demonstrated various types of hepatic lesions, such as fatty infiltration, hepatitis, and cirrhosis. No correlation could be made between the sparsity of hepatic lesions and the duration of enteritis, activity of the enteritis, malnutrition, loss of weight or extent of pathologic involvement of the small intestine. The absorption of large numbers of bacteria or their toxic products from the colonic flora and malnutrition are attractive etiologic hypotheses of hepatic disease occurring in chronic ulcerative colitis. Possibly, the absence of these factors in regional enteritis and the usually early surgical resection of the enteritis may be clues not only to the less frequent systemic complications of regional enteritis but also to the rarity of associated hepatic disease.

PSYCHOTHERAPEUTIC USE OF ACTH IN PSYCHOSOMATIC DISEASE

1. A case of chronic ulcerative colitis treated by inducing active patient collaboration in therapy with an internist and psychiatrist is reported. 2. Advantages and disadvantages of the psychotherapeutic use of ACTH and cortisone are considered. 3. ACTH and cortisone are discussed as valuable adjuncts to the psychotherapy of ulcerative colitis. 4. The philosophy of creating a collaborative therapist out of a chronically ill, masochistically-dependent individual by presenting the patient with personal control of ACTH as a "crutch" or tool, rather than an unrealistic panacea—we feel bears with it an explicit invitation to independent action and health. Such an approach may be applicable to other chronic psychosomatic diseases.

A Trial of Intravenous Trypsin in the Treatment of Chronic Ulcerative Colitis

Summary We are reporting seven cases of chronic ulcerative colitis treated with parenteral trypsin, five intravenously (Enzar), and two intramuscularly (Parenzyme) with no other therapy. Clinical and sigmoidoscopic improvement was observed in four, with evident and sustained remissions. We have no definite conclusions, nor are we able to speak of any permanent cure, in spite of the apparent beneficial effects observed in some of the patients. No fatality was observed, but almost every case had intolerance and side effects. We suggest the evaluation of this therapy by others but we wish to emphasize the potential complications.

Chronic ulcerative colitis; effect of a specific psychotherapeutic measure.

Summary A case of chronic ulcerative colitis of nine years' duration is presented. Of interest was the relationship of sudden symptomatic improvement of several months' duration to a single event in therapy. The reconstruction of the meaning of this event as "replacement therapy" seems clear from the psychodynamic background leading up to the onset of the disease. The fact that the improvement preceded any verbal interpretation or apparent intellectual comprehension of the psychological factors involved emphasizes the basic difference in technic of therapy necessary in some psychosomatic illnesses. The utility of such techniques to the general physician is discussed briefly.

Suppurative pylephlebitis with bacteremia in chronic ulcerative colitis.

Excerpt Suppurative pylephlebitis with bacteremia complicating chronic ulcerative colitis is rare.1A review of 783 cases of chronic ulcerative colitis and ileitis under our care failed to reveal th...

Normal Intestinal Bacteria in Ulcerative Colitis

Summary 1.In our series of cases of chronic ulcerative colitis, the mean total bacteria count was 14,000 billion/gram of wet feces, or 1.4 × 10 13 . The mean colif orm bacteria count was 5,970 billion/gram of wet feces, or 6 × 10 12 . 2.The total intestinal bacteria count is increased 85 fold, while the coliform bacteria count is increased 50 fold over that of the normal. 3.If one relies on a role of specifically injurious enzymes, such as lysozyme which denudes the epithelium of its mucous barrier, the pathogenesis of ulcerative colitis may be envisaged somewhat as follows: First, there is occasioned in some way not yet explainable, a marked increase in the total number of intestinal bacteria. Second, through enzymatic activity of these bacteria there is brought about initial damage to the mucosa. Third, there is actual, extensive destruction of the tissue by proteolytic bacterial enzymes, affording an opportunity for invasion and infection of the mucous membrane.

CHRONIC ULCERATIVE COLITIS AND CARCINOMA

THE PURPOSE of this communication is to present data on a series of 855 cases of chronic ulcerative colitis, with specific reference to the development of pseudopolyposis and carcinoma. A review of the literature appears to indicate a growing conviction that carcinoma may develop in patients with chronic ulcerative colitis and pseudopolyposis of long standing. The inference is that the malignant process occurs in the pseudopolyps and in association with, or as the result of, the existing chronic intestinal infection. The reported incidence of such malignant growths varies with different authors. Streicher (1938) 1 reported 1.2 per cent of 217 cases. Matzner and Schaefer (1939) 2 found the incidence of carcinoma among 185 patients with chronic ulcerative colitis to be 1.6 per cent, as compared with 0.5 per cent of the general hospital admissions. Brust and Bargen, 3 in 1934, reported an incidence of 2.5 per cent of 800 cases.

Specimen of Colon Removed on Account of Severe Pyoderma from a Long-Standing Case of Chronic Ulcerative Colitis

Specimen of Colon Removed on Account of Severe Pyoderma from a Long-Standing Case of Chronic Ulcerative Colitis

Human Infection with B. Necrophorum

Human infection with necrophorum is comparatively rare, although it is recognized as the cause of a variety of destructive lesions in many species of mammals and birds. Loeffler in 1884 isolated from diphtheria-like lesions in the throats of calves an anaerobic, pleomorphic, Gram-negative bacterium to which he applied the name Bacillus diphtheriae vitulorum. In animals this agent is responsible for necrotic infection in the oral cavity, skin, hoofs, genitalia, and intestinal tract. Embolic spread to practically all of the internal organs is frequent, especially to the liver and the lungs. It is a common cause of liver abscess in cattle and birds. necrophorum is representative of a group of similar or identical anaerobic bacteria described under different names. Consideration of the morphology, growth, and staining characteristics of these various organisms reveals an almost complete identity in essential points. Furthermore, the disease pictures produced by different members of this group both in man and lower animals bear a striking resemblance. Dach, Dragstedt and Heinz cultured this organism from an isolated loop of colon in three human cases of ulcerative colitis and from the bowels of two monkeys. In 1936 these same workers were able to recover necrophorum from the colons of thirteen out of twenty cases of ulcerative colitis, while cultures from six normal cases were negative. Complement-fixing antibodies for necrophorum were found in fourteen of sixteen cases of chronic ulcerative colitis. In a third contribution they state: Bacterium necrophorum has been found con-

LIFE HISTORIES OF NINETY-FIVE CHILDREN WITH CHRONIC ULCERATIVE COLITIS

Frequently it has been stated that the nature of chronic ulcerative colitis (thromboulcerative colitis) as it occurs during infancy and childhood, although the disease is basically the same as it is in later life, is prone to be more severe, that the outcome is more likely to be fatal and that a less satisfactory response of the patient to treatment occurs.¹It has been demonstrated that the opposite is true when this disease afflicts elderly persons or when persons experience symptoms of the disease late in life. In 1919 Logan²reported a series of 117 cases of chronic ulcerative colitis, and in 1923 one of us (Helmholz³) made the first report in the literature on the disease as it affects children. This report dealt with 5 cases. In 1924 Bargen's⁴work helped to establish the disease as an entity. During the last two decades considerable information

Antigenic Relationships of Strains of Bacterium Necrophorum

No criteria have been universally accepted for the classification of certain nonsporulating anaerobic bacteria which we call Bacterium necrophorum.1 Earlier work was concerned with their morphological, cultural and biochemical properties but not with their antigenic relationships until comparatively recent years.2,3'4'5,6 Studies of strains of Bact. necrophorum, isolated from cases of chronic ulcerative colitis, have shown the presence of specific antibodies in the serum of patients from whom they were isolated.7'8'9 There was evidence that certain of these strains were related serologically. In this investigation the problem of antigenic relationships among 12 strains, selected from different sources, was studied by means of agglutination and agglutinin absorption tests.