Case Of Angiolymphoid Hyperplasia Research Articles

A Case of Angiolymphoid Hyperplasia with Eosinophilia Treated with Combination Therapy of Topical and Intralesional Corticosteroids

Angiolymphoid hyperplasia with eosinophilia is an uncommon, benign vasoproliferative disorder that can present with single or multiple pink to red-brown dome shaped papules, predominantly on the head and neck. The most common reported symptoms include, but are not limited to, pruritus, bleeding and pain. Currently, there is no definitive treatment for this condition, with numerous therapeutic modalities described in the literature. The most effective and commonly used treatment is excision but can be more invasive and still has a high failure rate (40.3%). Despite the high failure rates associated with topical, systemic and Intralesional corticosteroids, we were able to show significant improvement with the combination of topical and Intralesional corticosteroids. This form of therapy is considerably cheaper and non-invasive compared to alternative therapies. Given the high recurrence and lack of definitive treatments, more research is needed for a better understanding of pathophysiology and identification of effective therapies. 

A Case of Angiolymphoid Hyperplasia with Eosinophilia Associated with Bowen's Disease.

A Case of Angiolymphoid Hyperplasia with Eosinophilia Associated with Bowen's Disease.

A Rare Case of Angiolymphoid Hyperplasia without Eosinophils, with Review of the Literature

The epithelioid hemangioma, more commonly termed angiolymphoid hyperplasia with eosinophils, is a pathologic vascular proliferation characterized by a distinctive eosinophil-rich mixed inflammatory infiltrate. A nonspecific accompanying infiltrate has only rarely been reported, and may confound the diagnosis of this benign process with malignant mimics. We present such a case of angiolymphoid hyperplasia without eosinophils, and consider its diagnosis and pathogenesis within the spectrum of related entities.

Surgical resection and skin graft repair for a case of angiolymphoid hyperplasia with eosinophilia of the posterior ear

A 34-year-old female patient presented with itchy nodules on the left posterior ear for 7 years. Skin examination showed clustered light-red or brown-black nodules measuring about 4 cm × 5 cm in size on the left posterior auricle, as well as from the posterior sulcus of the auricle to the anterior border of the hair line on the posterior auricle. Histopathological examination of the skin lesion revealed epidermal hyperkeratosis, proliferation of a lot of small blood vessels in the dermis, swelling vascular endothelial cells with enlarged nuclei and eosinophilic cytoplasm bulging into vascular cavity, and perivascular infiltration of lymphocytes and many eosinophils. The patient was diagnosed with angiolymphoid hyperplasia with eosinophilia. After extended surgical resection, a skin graft from the left lower abdomen was used to repair the defect. After the surgery, the flap survived well, and the appearance of the auricle was improved. No recurrence was observed during 1 year of follow-up. Key words: Angiolymphoid hyperplasia with eosinophilia; Surgical procedures, operative; Surgical flaps

Clinical and histological findings of a typical case of angiolymphoid hyperplasia without eosinophilia: a rare and difficult-to-treat disease

Clinical and histological findings of a typical case of angiolymphoid hyperplasia without eosinophilia: a rare and difficult-to-treat disease

Rare lesion, unusual location, uncommon presentation: a case of angiolymphoid hyperplasia with eosinophilia

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare vascular proliferation of unknown pathogenesis that may be related to trauma. Although it affects mainly the head and neck, the zygomatic area is rarely involved. We report a case that affected the zygomatic region of a 46-year-old black man. The lesion had been present for about a year and the patient reported that it appeared after a facial injury during a soccer match. Clinical and tomographic investigations suggested a benign tumour, and the lesion was excised through an intraoral approach. Histopathological examination showed the unexpected diagnosis of ALHE. This tumour was interesting because of its rarity, and also because of its unusual site within the head and neck region. The diagnosis of ALHE is hardly ever considered in the differential diagnosis of zygomatic nodules.

A case of angiolymphoid hyperplasia with eosinophilia of the orbit: anatomo-pathological features and treatment

A case of angiolymphoid hyperplasia with eosinophilia of the orbit: anatomo-pathological features and treatment

Angiolymphoid hyperplasia with eosinophilia in a hand treated with a reverse digital island flap and artificial skin: a case report

BackgroundAngiolymphoid hyperplasia with eosinophilia is a rare nodular skin tumor characterized by eosinophilic invasion and vascular proliferation. Previous reports suggested that irritation and inflammation are the causative factors of this disease. Most cases of angiolymphoid hyperplasia with eosinophilia occur around the auricle, forehead, and scalp; the hand is rarely affected. Moreover, the tumor seldom presents as multiple nodules.Case presentationA 67-year-old Japanese woman presented with a complaint of skin masses on her left thumb and index finger, which had gradually grown in size over the past few months. A biopsy was performed confirming a diagnosis of angiolymphoid hyperplasia with eosinophilia. The aponeurosis on her index finger was resected and tissue was reconstructed using a reverse palmar digital island flap harvested from the base of her index finger. The thumb lesion was also resected and covered with collagen-based artificial skin. Gradual progression of skin epithelialization followed by healing was noted 2 months after the surgery.ConclusionAngiolymphoid hyperplasia with eosinophilia is a rare tumor; it is seldom seen in the hands. It is generally treated by surgical resection. It is important to resect a sufficiently large area of the tissue due to the possibility of relapse in some cases. Furthermore, appropriate reconstruction is mandatory after wide margin tumor resection.

Case of Angiolymphoid Hyperplasia with Eosinophilia Associated with Anti-TNF Inhibitor

Case of Angiolymphoid Hyperplasia with Eosinophilia Associated with Anti-TNF Inhibitor

Dermoscopic features in 2 cases of angiolymphoid hyperplasia with eosinophilia

Dermoscopic features in 2 cases of angiolymphoid hyperplasia with eosinophilia

Angiolymphoid hyperplasia with eosinophilia of oral mucosa in a child treated with imiquimod

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare and idiopathic disorder of blood vessels which is common in head and neck area of middle-aged women. We report a case of angiolymphoid hyperplasia of lower lip in a 7-year-old child, confirmed by histopathological findings of hyperplastic lymphoid follicles, eosinophilia, and proliferation of vessels and positive staining with CD3 and CD20 in immunohistochemistry. Lesion was treated with imiquimod for 16 weeks following which it resolved completely. We present this case for the rarity of the case in this age group on an atypical rare site. To the best of our knowledge, this is the first reported case of ALHE on oral mucosa of a male child.

The vascular marker CD31 also highlights histiocytes and histiocyte-like cells within cutaneous tumors.

While useful in diagnosing angiosarcomas, CD31 can also highlight histiocytes within soft tissue tumors and lead to errors in diagnosis. We sought to determine how often CD31 highlights cutaneous histiocytomas and histiocytoma mimics. We examined eight epithelioid cell histiocytomas (ECHs), 12 xanthogranulomas (XGs), nine cases of Langerhans cell histiocytosis (LCH), eight reticulohistiocytomas, 11 xanthomas, 29 atypical fibroxanthomas, nine granular cell tumors, four cases of angiolymphoid hyperplasia with eosinophilia, nine intradermal Spitz nevi, and nine angiosarcomas with antibodies directed against CD31, CD34, CD163, and factor VIII. CD31 marked cells in three of 12 XGs, four of nine cases of LCH, one of eight reticulohistiocytomas, one of 11 xanthomas, 10 of 29 atypical fibroxanthomas, four of four cases of angiolymphoid hyperplasia with eosinophilia, nine of nine angiosarcomas, zero of nine granular cell tumors, and zero of eight ECHs. CD34 and factor VIII were negative in all nonvascular cases. Our results indicate that CD31 can mark lesional cells and imitate vascular tumors in cutaneous histiocytomas and histiocytoma mimics, an error that can be avoided by using a panel of antibodies.

Angiolymphoid Hyperplasia with Eosinophilia: A Previously Unreported Complication of Ear Piercing

Angiolymphoid hyperplasia with eosinophilia is a rare, benign vascular lesion characterized by discrete, painful papules. Although the exact etiology is unknown, trauma precedes many cases. We present a case of angiolymphoid hyperplasia with eosinophilia in the earlobes of a 15-year-old girl after ear piercing.

A Case of Angiolymphoid Hyperplasia with Eosinophilia (ALHE) of the Eyelid

A Case of Angiolymphoid Hyperplasia with Eosinophilia (ALHE) of the Eyelid

Case of angiolymphoid hyperplasia with eosinophilia associated with scabies infestation

Case of angiolymphoid hyperplasia with eosinophilia associated with scabies infestation

A case of angiolymphoid hyperplasia with eosinophilia (ALHE) in the genital area accompanied by varicocele

A case of angiolymphoid hyperplasia with eosinophilia (ALHE) in the genital area accompanied by varicocele

A Case Of Angiolymphoid Hyperplasia With Eosinophilia Aggravated During Pregnancy

Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon and benign vascular disorder characterized by angiomatous, pink-red papulonodular lesions mainly located on the scalp, neck, and periauricular region. Although the exact cause of ALHE is unknown, several etiologic factors including insect bites or parasites, trauma, hyperestrogen states, and immunologic factors have been implicated in the pathogenesis of the disease. Only a few cases of pregnancy related ALHE so far have been reported in the literature. In this article, we report a case of ALHE with postauricular location aggravated during the first trimester of pregnancy.

Atypical inflammatory lesions in the orbit and adnexae

Abstract Purpose The common use of an initial systemic steroid treatment trial in orbital and adnexal inflammatory disease is now more questionable and used less frequently. The increased availability of specialized oculoplastic and orbital surgeons has enabled us to biopsy masses of the orbit routinely in recent years. As a result unusual pathology appears more commonly than expected in previous years. We reviewed the diagnosis and presentation of unusual inflammatoty lesions of the orbit biopsied over the past 8 years in our oculoplastic and orbital clinic. Some interesting representative cases are presented. Methods A search of the operation register and recorded diagnosis of pathology specimens was carried out and a retrospective review was made of all patients with unusual orbital inflammatory lesions presenting at the oculoplastic surgical service in Meir Medical Center between 1999 and 2008. All cases had CT imaging of the orbits and underwent biopsy of the lesion. Pathology examination was performed on all specimens following biopsy. Results There were 5 cases of non caseating granulomas in the Orbit, 1 case of Churg Strausse syndrome, 2 cases of lymphoid hyperplasia, 1 case of infectious mononucleosis dacryoadenitis, 2 cases of Eosinophillic Granuloma, 1 case of malignant schwannoma, 2 cases of angiolymphoid hyperplasia, 1 case of Sclerosing type idiopathic orbital inflammatory disease and 1 orbital abscess with an unusual presentation Conclusion We recommend biopsy of all orbital inflammatory masses before beginning treatment with steroids. Unusual pathology is more likely than expected and may have significant implications for the well being of patients.

A case of angiolymphoid hyperplasia with eosinophilia successfully treated with tacrolimus ointment

A case of angiolymphoid hyperplasia with eosinophilia successfully treated with tacrolimus ointment

Angiolymphoid hyperplasia with eosinophilia (epithelioid haemangioma) occurring within multiple deep lymph nodes and presenting with weight loss and raised CA-125 levels

We report a case of angiolymphoid hyperplasia with eosinophilia (epithelioid haemangioma) involving multiple deep mediastinal, abdominal and intramammary lymph nodes in a 52-year-old woman with weight loss and raised CA-125 levels. The unusual clinical presentation with raised CA-125 levels and its occurrence within multiple deep visceral lymph nodes has never been reported in literature.