Cases Of Anemia Research Articles

Multimorbidity in patients with monoclonal gammopathy of undetermined significance.

Monoclonal gammopathy of undetermined significance (MGUS), a precursor to multiple myeloma, is present in over 5% of adults aged 70 and older, a population with a high prevalence of multimorbidity. MGUS is often diagnosed incidentally when patients seek care for unrelated conditions. Our study sought to examine patterns of multimorbidity among MGUS patients, as overall health may impact patient care and the prioritization of MGUS surveillance. We examined patterns of comorbidities in 429 patients diagnosed with MGUS (2007-2015) and 1287 matched controls. Twenty-seven conditions were defined at diagnosis/index date using algorithms developed by the Centers for Medicare and Medicaid Chronic Conditions Warehouse. Patterns of common comorbidities were identified individually, in dyads and triads, and compared between MGUS cases and controls. We conducted a latent class analysis to identify comorbidity patterns among cases only. We also examined comorbidity patterns among a subset of 32 MGUS cases who progressed to cancer during the study period. The most common comorbidities among both MGUS cases and controls included hypertension and hyperlipidemia. Anemia (cases: 43%; controls: 16%) and chronic kidney disease (CKD; cases: 36%; controls: 18%), and dyads and triads containing those conditions, were more common among cases. Latent class analysis identified three classes of comorbidity among MGUS cases: hypertension-hyperlipidemia plus anemia and CKD (31%); low comorbidity burden (17%); and hypertension-hyperlipidemia alone (52%). The higher prevalence among cases of anemia and CKD, which may be involved in the pathogenesis of, or surveillance for, MGUS, warrants additional investigation.

COMPARATIVE STUDY OF AUTOMATED CELL COUNTER HISTOGRAM AND PERIPHERAL BLOOD SMEAR IN DIAGNOSIS OF ANEMIA

Introduction: Over the past few years, complete blood count, RBC histogram and peripheral blood smear have become the important diagnostic tools to diagnose various haematological conditions. Major public health burden worldwide is anemia with high prevalence in developing countries like India1. Red blood cell and histogram are indispensable for diagnosis and management of anemia2. The major diagnostic tool for work up of most commercial laboratories has been analysing the blood lm routinely. The aim AIM: of the study is to compare between automated cell counter histogram and peripheral smear nding in diagnosis of anemia. Material and method: A prospective comparative study of RBC histogram and peripheral blood smear in diagnosis of anemia was done on 100 patients of HB<14gm%, over six month time span (June2022-Nov2022) in the central laboratory of Saraswathi Institute of Medical Sciences Hapur, (UP) India. This study included all the age groups. All cases of anemia that have undergone blood transfusion is excluded from this study. In Result: our study it was observed that on peripheral blood smear, the most common type of anemia was microcytic hypochromic anemia followed by normocytic normochromic anemia, when we compared with automated cell counter generated histogram most common type of anemia was normocytic normochromic followed by microcytic hypochromic anemia. In our study female population were more than males. The mean age was(32.4yr). Automated cell counters generated CBC histograms and peripheral blood smears Conclusion: plays a major role in diagnosis and management of red cell disorder. Our study observed that histogram patterns and their conrmation by peripheral blood smear along with clinical history gives accurate and conrmed diagnosis of various haematogical conditions. There is much improvement in accuracy and precision 3 reducing the subjective errors .

Community Radio in India: A Model of Participatory Communication inIndia

Community Radio in India: A Model of Participatory Communication inIndia

Lamivudine induced pure red cell aplasia and HIV-1 drug resistance-associated mutations: a case report

Adverse effects linked to antiretroviral therapy (ART) may contribute to poor adherence on the patient's side. Consequently, human immunodeficiency virus (HIV) drug resistance mutations could emerge, negatively impacting the body's immune system. Meanwhile, severe immunosuppression can lead to several conditions, including anemia. The cause of anemia in HIV infection is multifactorial, and can be mainly explained by deleterious direct effects of the virus on the bone marrow, and opportunistic infections such as Parvovirus B19. Other causes include blood loss resulting from neoplasms and gastrointestinal lesions. Moreover, anemia can also be caused by antiretroviral drugs. We report a case of persistent anemia after ART initiation, kidney injury and treatment failure following a lengthy period of non-adherence to ART. The anemia was classified as Pure Red Cell Aplasia (PRCA). With treatment modification, the anemia resolved and the patient attained virologic suppression. Lamivudine (3TC) was pointed out as the cause of PRCA, which resolved after its withdrawal from the ART regimen. This rare side effect should be investigated in patients on 3TC who present with recurrent anemia.

PATTERNS AND DEMOGRAPHIC DISTRIBUTION OF HEMOGLOBINOPATHIES DIAGNOSED ON HPLC IN A TERTIARY CARE HOSPITAL OF NORTH EASTERN INDIA

Introduction: Hemoglobinopathies are the most common genetic disorders reported in the World. According to WHO, 5% of the world population is a carrier for hemoglobin disorder. The aim of the study was to determine the Aims and objective: prevalence and demographic prole of hemoglobinopathies in a tertiarty care hospital. During 1 year period, a cross-secti Materials and Methods: onal study was carried out on 150 microcytic hypochromic anaemic patients samples (Hb <11g/dl) of age 1-18 yrs. All the samples were tested for complete blood count and sent for HPLC study. Out of 150 cases, 114 cases were diagnosed as having hemoglobinopathies Results: by HPLC with its prevalence being 76%. With a slight male preponderance was seen (52.6%). The most common hemoglobinoapthy being detected was HbE trait (28%) followed by HbE disease (26.67%). While β thalassemia trait was 13.33%, β thalassemia major was 0.67% and HbE with β thalassemia was 7.33%. The most affected community are the Tribal community with a prevalence of 21.05% followed by the Tai Ahom community (17.54%). Assam is a rich Conclusion: reservoir of hemoglobinopathies as nearly 60% of all cases of anemia coming for investigations may show some form of this disorder. Since there is no effective treatment for this disease, so carrier detection and awareness programmes have to be conducted at community level for its control and prevention

SEVERITY AND CLINICO-HAEMATOLOGICAL FEATURES OF APLASTIC ANEMIA IN ADULTS PRESENTING TO PUBLIC SECTOR TERTIARY CARE HOSPITAL OF LAHORE: A DESCRIPTIVE CROSS SECTIONAL STUDY

Background & Objective: Aplastic anemia is a rare and heterogeneous disorder. Literature shows inconsis- tencies in frequency and its clinico-hematological findings. Objective of this study was to assess frequency of different severity grades and clinico-hematological features in newly diagnosed cases of aplastic anemia in adults.
 Methods: In this descriptive, cross-sectional study, conducted in Allama Iqbal Medical College Lahore from October 2021 through April 2022, a total of 100 diagnosed cases of acquired aplastic anemia were included. Modified Camitta's criteria were applied to assess the severity of aplastic anemia. Clinical features such as pallor, fever and bleeding manifestations were determined by history and physical examination. About 3ml whole blood was collected in EDTA vial and run for complete blood count on automated hematology analyzer for hematological Parameters (Hb, Platelets, total leukocyte count and absolute Neutrophil count). Data were entered and analyzed using SPSS version 20. Quantitative variables like age, Hb, TLC and platelet count were expressed as mean ±Standard deviation. Qualitative variables such as gender, severity of aplastic anemia and clinical features were expressed as percentages.
 Results: In this study, 55% participants were male and 45% were female. All patients had pallor, 61% had fever and 66% had bleeding on presentation. Regarding severity of aplastic anemia, 56% were categorized as severe, 24% as very severe and 20% were as non severe aplastic anemia.
 Conclusion: Severe aplastic anemia is frequent among male population and at younger age. This information has prognostic implications. Therefore, all patients with aplastic anemia should be assessed for severity for further clinical management.

Etiological and Evolutionary Profile of Anemia in Outpatients at the Internal Medicine Unit of the Fousseyni Daou Hospital in Kayes

Introduction: Anemia is one of the most common public health problems in the world and affects all ages. Objective: To describe the etiologycal and evolutionary profile of anemia in the internal medicine unit of the Fousseyni Daou hospital in Kayes. Methodology: It was a descriptive and cross-sectional study with retrospective data collection which took place from January 1 to December 31, 2020 at the Internal Medicine Unit of the Fousseyni Daou Hospital in Kayes. It covered all anemic patients seen in outpatient clinics during the study period. Results: We identified 197 cases of anemia out of 1883 patients admitted to the Unit, either a hospital prevalence of 10.46%. The age group from 26 to 35 years was the most represented, that is to say 67 cases (34.01%) with an average age of 25 years, the female sex predominated, 107 cases (54.31%) with a sex ratio of 0.84. Housewives represented 104 cases (52.8%). The majority of patients resided in rural areas 48 cases (52.75%). Gastropathy was the most found antecedent 76 cases (38.58%) followed by hypertension 53 cases (26.90%); 121 patients (61.42%) had no history. The main clinical manifestations were: conjunctival pallor 118 cases (59.9%), vertigo 112 cases (56.85%), physical asthenia 109 cases (55.33%), dyspnea 101 cases (51.26 %), headaches 99 cases (50.25%). The associated pathologies were: hypertension 76 cases (38.58%), followed by malnutrition (anorexia) 67 cases (34.01%). Biologically, microcytic anemia was the most frequent 127 cases (64.47%), followed by normocytic anemia 53 cases (26.90%) and macrocytic anemia 17 cases (8.63%). Normochromic anemia was more encountered in 104 cases (52,79%) compared to anemia hypochromic 93 cases (47.21%). Mild anemia was more frequent 119 cases (60.41%) followed by moderate anemia 62 cases (31.47%). Anemia was severe in 16 cases (8.12%). The main etiologies of anemia were iron deficiency 98 cases (49.75%) followed by infections (anemia of inflammatory origin) with ..........

Acute kidney injury following autoimmune hemolytic anemia due to simultaneous use of ciprofloxacin and hydrochlorothiazide: A case report and review of the literature

AbstractIntroductionRare cases of autoimmune hemolytic anemia (AHA) associated with using ciprofloxacin or hydrochlorothiazide (HCTZ) alone have been reported before. However, simultaneous use of both drugs could lead to a severe clinical condition. This study presents the combination of acute kidney injury (AKI) and AHA following the simultaneous use of ciprofloxacin and HCTZ for three days.Case DescriptionA 42‐year‐old Iranian woman presented to the emergency department with symptoms of fatigue, lethargy, nausea and vomiting, ataxia, oliguria, dark urine, and jaundice. The patient reported using HCTZ due to high blood pressure and ciprofloxacin for a urinary tract infection three days before presentation. Early laboratory findings revealed hemolytic anemia with a hemoglobin of 7 g/dl, the strongly positive direct and indirect Coombs test, high level of lactate dehydrogenase (820 IU/L), and hyperbilirubinemia (total: 3 mg/dL and direct: 1.2 mg/dL). Furthermore, hyperkalemia (5.2 mEq/L), hyperphosphatemia (6.2 mg/dL), high levels of BUN (100 mg/dL), and creatinine rise (6.8 mg/dL) were found. Urine analysis showed 2+ blood, 4‐6 red blood cells, and cola‐colored urine. Based on the findings, drug‐induced AHA, followed by AKI, was diagnosed. Following, the drugs were stopped and steroid therapy was initiated. The patient underwent four sessions of hemodialysis to improve the AKI.ConclusionHealthcare providers should be aware of the life‐threatening adverse effects of commonly used drugs such as ciprofloxacin or HCTZ. The timely diagnosis of the offending drugs leads to avoiding the persistence of the risk factor and the deterioration of the patient's clinical condition.

Hubungan Pengetahuan, Sikap dan Dukungan Keluarga Dengan Kepatuhan Ibu Hamil Trimester III Mengkonsumsi Tablet Besi (Fe) di Wilayah Kerja Puskesmas Karang Mukti Kecamatan Lalan Tahun 2021

In Indonesia, there are 41 cases of anemia in pregnant women every day, and 20 women die due to anemia. This high number is due to the low ignorance of the mother about the dangers of anemia in pregnancy which tends to appear in the 1st and 3rd trimesters of pregnancy. Aims to determine the relationship between Knowledge, Attitude and Family Support with the Compliance of Pregnant Women in the Third Trimester Consuming Iron (Fe) Tablets in the Work Area of Karang Mukti Health Center, Lalan District. This type of research is an analytical survey using a cross sectional approach design. The population in this study were all mothers in the third trimester of 2021, which amounted to 186 people and the number of samples was 65 respondents. The sampling technique used was purposive sampling. Analysis of the data used is the chi-square statistical test with p value value (0.05). The results of this study from 65 respondents, there is a relationship between knowledge and adherence of pregnant women to consume Fe tablets, p value = 0.000, there is a relationship between attitudes and adherence to pregnant women taking Fe tablets, p value = 0.02 and there is a relationship between family support and compliance with pregnant women taking tablets. Fe p value = 0.03. It is expected to be able to improve health services to the community through various methods, both health counseling to reduce maternal mortality.

Unusual symptoms of iron deficiency anemia (2 clinical observations)

Iron deficiency is a leading cause of anemia, the most common malnutrition worldwide, affecting 42% of children worldwide. Most often, iron deficiency occurs in children of the first year of life and adolescents; its prevalence in adolescents has pronounced gender differences. In Russia, it is much more common in girls in 17.231.0% of cases, which is 1.6 times higher than in boys. The presence of delayed adverse effects of iron deficiency at an early age has been established, therefore, timely correction of sideropenic conditions in young children is important for the prevention of long-term consequences of a childs development. The article presents two clinical cases of iron deficiency anemia in adolescent girls who had iron deficiency in the first year of life. On the example of the first clinical observation, we observe the development of alopecia against the background of severe sideropenia as part of the epithelial syndrome with iron deficiency anemia of moderate severity. Iron deficiency in this case is multifactorial maternal anemia during pregnancy, spontaneous subarachnoid hemorrhage, shunt infection, and uncorrected iron deficiency in the first two years. The second clinical example illustrates iron deficiency anemia of mixed genesis in a teenage girl, which was the result of insufficient iron stores at birth, alimentary insufficiency, aggravated against the background of heavy, prolonged menstruation. In this case, there is no hair loss, despite the more severe course of anemia, a long refractory period with iron therapy. The data of clinical cases confirm the significance of low iron stores at birth in the risk of developing iron deficiency anemia in puberty. During the examination of children, the need to take into account the state of the gastrointestinal tract in the algorithm for diagnosing the state of the gastrointestinal tract (detection of malabsorption, blood loss) was shown.

Lipid Profile in Anemic Patients: A Cross Sectional Study

Introduction: Anemia is a common disorder in India, although there are plenty of reasons attributable to Anemia. Studies are reporting the beneficial effect of Anemia on lipid profile. Aim: This research was conducted to study the pattern of lipid profiles in anemic patients. Material and Method: Present hospital-based cross-sectional study was conducted among patients more than 18yrs of age attending the OPD or admitted to the medicine department National Institute of Medical Sciences and Research, Jaipur, with diagnosed Anemia. The study was done over a period of two years on patients with proven cases of Anemia. After informed & written consent from the patients, detailed history, clinical assessment & laboratory investigation was done. Results: In the present study a total of 280 patients fulfilling inclusion criteria are included in the study. The mean age of the patients was found to be 39.44±14.92yrs; among them, 60% were female, and 40% were male patients with female preponderance. There was significant positive strength of association of hemoglobin with the lipid profile, which included the total cholesterol, LDL, HDL, triglycerides, and VLDL cholesterol l(p<0.05). Conclusion: The present study showed a significant strength of association between the hemoglobin level and the lipid profile parameters. Also, the lower mean level of lipid parameters with the severity of grade of Anemia.

Clinical features of anemia in membranous nephropathy patients: a Chinese cohort study

Background Anemia is a common complication in patients with progressive chronic kidney disease. This cohort study evaluated the prevalence, clinical features and prognosis of membranous nephropathy (MN) with anemia. Methods We retrospectively analyzed a cohort of MN patients diagnosed using renal biopsy between February 2012 and February 2018. The clinical and pathological characteristics at baseline were recorded, and the outcomes (hemoglobin, proteinuria and renal function) during follow-ups were also evaluated. Univariate and multivariate logistic regression analyses were performed to identify the independent risk factors for anemia in MN patients. The MN patients were divided according to the therapeutic effect they experienced as follows: without-anemia, completely corrected anemia, standard anemia treatment and nonstandard anemia treatment groups. We compared the rate of complete remission of MN and renal end-point events among the four groups. Results The median age of 483 patients was 42.43 (26.59, 50.20) years at the time of MN diagnosis. The prevalence of anemia at baseline was 23.81%, and the cumulative prevalence was 50.72%. There were 133 cases of mild anemia, 103 cases of moderate anemia and 9 cases of severe anemia; in addition, there were 228 cases of normocytic anemia and 17 cases of microcytic hypochromic anemia. Multivariate logistic regression indicated that acute renal tubule injury >5% (OR = 1.634, 95% CI 1.034, 2.581; p = 0.035), total protein level (OR = 0.949, 95% CI 0.923, 0.975; p < 0.001), cholesterol level (OR = 0.833, 95% CI 0.749, 0.926, p = 0.001), hypokalemia (OR = 2.612, 95% CI 1.227, 5.560, p = 0.013) and hypophosphatemia (OR = 2.653, 95% CI 1.303, 5.403, p = 0.007) were independent risk factors for anemia in MN patients. The complete remission rate of MN patients without anemia was significantly higher than that of anemia patients who exhibited treatment failure. The incidence of renal endpoint events was different among the four groups. Conclusion The anemia experienced by MN patients is mainly mild and moderate, normocytic anemia. The pathological features of acute renal tubular injury and clinical nutritional status are independent risk factors for anemia. There were differences in renal prognosis among anemia patients with different treatment outcomes.

Autoimmune Hemolytic Anemia in Children: Clinical Profile and Outcome.

To discover the common triggers for AIHA in children, their clinical profile, treatment response, and outcome. This was an ambispective descriptive study conducted between 2013 and 2020. Children aged 1 mo to 14 y with hemolytic anemia and a positive direct antiglobulin test (DAT) were included. Children with a positive DAT but without any clinicolaboratory evidence of hemolysis were excluded. Data were collected from a structured pro forma with particulars comprising clinicolaboratory profile, treatment administered, and disease outcome. A total of 46 children (aged between 1 mo and 14 y) were enrolled in the study. The mean age of onset was 8.7 (± 4.34) y, and 24 (52.8%) were males. Secondary causes were observed in 29 (63%) cases, while the primary cause was found in 17 (37%). Systemic lupus erythematosus (SLE) was the common trigger in 13 (45%) cases, followed by malignancy in 4 (14%) cases. Pallor (98%), hepatomegaly (72%), and splenomegaly (48%) were the most commonly observed clinical signs. The mixed immunophenotype was observed in 27 (59%) cases, followed by warm type in 12 (26%) and cold agglutinin type in 7 (15%) cases. All children received glucocorticoid therapy, and mycophenolate mofetil was commonly used as second-line therapy in 15 (33%) cases. 13 cases (71%) of primary AIHAand only 4 (14%) cases of secondary anemia achieved complete remission. Overall, 7 children (15%) died, all belonging to secondary AIHA. Secondary AIHA was more common than primary in the present study, and SLE was the standard trigger. Primary AIHA carries a better prognosis than secondary.

Severe-Rigid Scoliosis Treated by Two-Staged Procedures: A Case Series

In developing countries, a large proportion of patients with scoliosis present late, especially the underprivilege, so the curves had become rigid and severe. There is still no consensus about the surgical management of the severe and rigid scoliosis and some literatures suggested that combined anterior and posterior or single-stage posterior-only instrumentation are generally required for the correction of these deformities. We presented three cases of severe rigid scoliosis treated surgically in our center with two staged operation (anterior surgery and posterior instrumentation). A retrospective review was undertaken of patients with severe scoliosis who had undergone two-staged operation in Orthopaedics and Traumatology Department of Prof Ngoerah General Hospital Bali during the period between January 2018 and February 2020. The data was obtained from the hospital’s medical records and archives in our department, included sex, age, the severity and reducibility of the Cobb angle, maturity rate, treatment, length of stay, complications found, and the Scoliosis Research Society: 30 Questionnaire (SRS-30) score before and three months after the surgery. During the period of between January 2018 and February 2020, there were three cases of severe rigid scoliosis who underwent two-staged operation. The two staged operation performed were anterior surgery (soft tissue release, corpectomy, and anterior fusion), and posterior instrumentation (facetetectomy, rotation, stabilization, and fusion). There were one case of intra-operative hypovolemic shock and anemia that could be corrected succesfully. All three patients showed no complaint and the clinical examination showed improvements of the deformity post operatively. There were also improvement of the total SRS-30 score of all three patients after the two staged procedures performed (mean = 4.4) compared to pre-operative score (mean = 3.4). The two-staged operation including anterior surgery and posterior instrumentation is still a safe and effective way in treatment of severe rigid scoliosis.

Study of hematology according to the morphology classification and Some Biochemical Values Changes Associated With Morphological Anemia

This study was conducted on sheep to determine the changes in hematological and biochemical parameters in anemic cases by using morphological classification, one hundred and thirty serum samples were collected sheep aged 1 – 5 years, they were grazing on pasture from the different districts of Tikrit. which was a sample of 100 sheep suffered from anemia and 30 sample was intact. The results showed that the sheep's which suffer from anemia, a significant decrease in RBC count, Hb concentration, PCV, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration in normocytic normochromic ( 0.3±6.5 × 106µ/L), (0.49±6.1 g/dl), (0.29±18.6%), (0.33±28.6 fl), (0.72±9.4 pg), (0.61±33.03 g/dl) respectively. In microcytic hypochromic, (0.63±7× 106µ/L) ,( 0.23±6 g/dl) ,( 0.07±18%) ,( 0.34±25.7 fl) ,( 0.04±8.57 pg) (0.89±33.33 g/dl) respectively. But in macrocytic normochromic (0.17±6.3× 106 µ/L) ,(0.19±7.4 g/dl) , (0.8±22.3%) ,(1.77±34.9 fl) ,(0.67±11.5 pg) (1.11±33.1g/dl) respectively. In macrocytic hypochromic, (0.41±6.7× 106µ/L) , (0.16±7.8 g/dl) ,(0.13±23.5%) ,(1.01±35.1 fl) ,(0.63±11.6 pg) (1.5±33.1 g/dl) respectively. The results showed a significant decrease ( P &lt; 0.05 ) in the rates of total protein concentration , albumin , iron, copper and zinc (0.16±5.2 g/dl), (0.29±1.16 g/dl), (0.2±117.66 µg/dl), (0.08±42.87 µg/dl), (0.32±39.76 µg/dl) respectively in the serum of sheep infected according the compared with sheep intact.

Hemoglobin Level as a Predictor of Major Adverse Cardiovascular Events and Short-term Outcomes in Stemi Patient Treated with Pharmacoinvasive Strategy versus Primary PCI

Background: Anaemia is prevalent among cases with acute coronary syndrome (ACS) and has been linked to poor clinical prognosis. Guidelines for cases with ST-segment elevation myocardial infarction (STEMI) recommend timely primary percutaneous coronary intervention (pPCI) as the preferred reperfusion strategy. If timely pPCI cannot be performed, a pharmacoinvasive strategy (PI) is recommended within 12 hours of symptom onset. The aim of this work was to study and assess the impact of hemoglobin level as a predictor of MACE and short-term outcomes in cases treated with Primary PCI vs pharmacoinvasive strategy.&#x0D; Methods: This prospective case-control observational study was conducted on 100 cases that were divided into 2 groups. Group I consisted of 50 anaemic cases &amp; group II consisted of 50 cases that were not anaemic. Both groups were subdivided into A subgroups that underwent revascularization by pPCI and B subgroups that underwent revascularization by pharmacoinvasive strategy.&#x0D; Results: There was no significant difference in LVEF, infarct site and final TIMI flow, the anaemic groups showed statistically significant more total MACE than non-anaemic groups whether revascularized by pPCI or pharmacoinvasive strategy. As expected, anaemic cases tended to have higher bleeding complications especially those undergoing pharmacoinvasive strategy. The anaemic cases also were less likely to be discharged on RAAS and beta blockers.&#x0D; Conclusions: Anaemic cases whether revascularized with pPCI or pharmacoinvasive strategy tend to have higher incidence of MACE and major bleeding with no significant difference in mortality. There was no significant difference between LVEF between the study groups.

Tingkat pengetahuan siswi SMA Negeri 1 Teupah Barat tentang manfaat konsumsi tablet Fe

The incidence of anemia in Indonesia is still quite high. Based on Riskesdas 2018 data, the prevalence of anemia in adolescents is 32%, meaning that 3-4 out of 10 adolescents suffer from anemia, the Aceh Nutritionist Association (Persagi), explained that there are still many cases of anemia in young women in Aceh and the number is high enough that it needs supervision about giving Fe tablets. The purpose of this study is generally to find out an overview of students' knowledge about the benefits of consuming blood-added tablets at SMAN 1 Teupah Barat in 2022. This research method uses a quantitative type of research with a cross-sectional study design. The location of this study was conducted at SMAN 1 Teupah Barat, Aceh Province. The study population was all students of SMAN 1 Teupah Barat, Aceh Province.The technique used was a total sampling of 156 students. The survey data were analyzed using univariate tests. The results of the study obtained that good female students' knowledge about the consumption of Fe tablets was 123 people (78.8%), sufficient female students' knowledge about the consumption of Fe tablets as many as 20 people (12.8%) and insufficient student knowledge as many as 13 people (8.3%).

Anti-RH1 alloimmunization: At what maternal antibody threshold is there a risk of severe fetal anemia?

To define a threshold of maternal antibodies at risk of severe fetal anemia in patients followed for anti-RH1 alloimmunization (AI). We conducted a retrospective study of patients followed for anti-RH1 AI at the Lille University Hospital. The first group, severe anemia, included patients who received one or more in utero transfusions (IUT) or who were induced before 37 weeks of pregnancy for suspected severe fetal anemia. The second group, absence of severe anemia, corresponded to patients without intervention during pregnancy related to AI. Sensitivities, specificities, and positive and negative predictive values for screening for severe fetal anemia were calculated for the antibody thresholds of 3.5 and 5IU/ml for the quantification. Between 2000 and 2018, 207 patients were included 135 in the severe anemia group and 72 in the no severe anemia group. No severe anemia was observed for an antibody titer below 16. For an antibody threshold of 3.5IU/ml, the sensitivity was 98.2%, with 30.2% false positives. All severe anemias were detected in the second trimester; two cases of severe anemia were not detected in the third trimester. For an antibody threshold of 5IU/ml, the sensitivity was lower at 95.6%, with five cases of severe anemia not detected. The antibody threshold of 3.5IU/ml for the quantification and 16 for the titration allow targeting patients requiring close monitoring by an experienced team in case of anti-RH1 AI.

Analysis of the anemia characteristics in early pregnancy and outcomes of pregnant women with hemoglobin H disease.

This study aimed to analyze the anemia characteristics in early pregnancy of pregnant women with hemoglobin H (Hb H) disease and their pregnancy outcomes, and to provide reference to the pregnancy management and treatment of these women. Twenty-eight cases of pregnant women who had been diagnosed with Hb H disease in the Second Affiliated Hospital of Guangxi Medical University from August 2018 to March 2022 were retrospectively analyzed. Moreover, 28 cases of normal pregnant women in the same period were randomly enrolled as a control group for comparison. The means and percentages of the anemia characteristics in early pregnancy and the pregnancy outcomes were calculated and the analysis of variance, Chi-square test, and Fisher's exact test were applied for comparison. A total of 13 cases of missing type (46.43%) and 15 cases of non-missing type (53.57%) were observed in the 28 cases of pregnant women with Hb H disease. The genotypes were as follows: 8 cases of -α3.7/--SEA (28.57%), 4 cases of -α4.2/--SEA (14.29%), 1 case of -α4.2/--THAI (3.57%), 9 cases of αCSα/--SEA (32.14%), 5 cases of αWSα/--SEA (17.86%), and 1 case of αQSα/--SEA (3.57%). Twenty-seven patients with Hb H disease (96.43%) were anemic, including 5 cases of mild anemia (17.86%), 18 cases of moderate anemia (64.28%), 4 cases of severe anemia (14.29%), and 1 case of non-anemia (3.57%). Compared with the control group, the Hb H group had significantly higher red blood cell count and significantly lower Hb, mean corpuscular volume, and mean corpuscular hemoglobin, and the differences were statistically significant (p < 0.05). The Hb H group had higher incidence rates of blood transfusion during pregnancy (BTDP), oligohydramnios fetal growth restrictions (FGR), and fetal distress than the control group. The weights of neonates were lower in the Hb H group than in the control group. Statistically significant differences were found between these two groups (p < 0.05). The genotype missing type of pregnant women with Hb H disease was mainly -α3.7/--SEA and the non-missing type was mainly αCSα/--SEA. Hb H disease can easily cause various degrees of anemia (mainly moderate anemia in this study). Moreover, it can increase the incidence rate of pregnancy complications such as BTDP, oligohydramnios, FGR, and fetal distress, which will reduce the weight of neonates and seriously affect maternal and infant safety. Therefore, maternal anemia and fetal growth and development should be monitored during pregnancy and delivery, and transfusion therapy should be used to improve adverse pregnancy outcomes caused by anemia when necessary.

381 - Lovo-cel (bb1111) Gene Therapy for Sickle Cell Disease (SCD): Updated Group C Clinical Results and Investigations into Two Cases of Anemia from the Phase 1/2 HGB-206 Study

381 - Lovo-cel (bb1111) Gene Therapy for Sickle Cell Disease (SCD): Updated Group C Clinical Results and Investigations into Two Cases of Anemia from the Phase 1/2 HGB-206 Study