Background First described in 1959 by Waldron and more fully characterized by Loyola et. al. in 2014, adenoid ameloblastoma (with dentinoid) is a rare odontogenic tumor variant with less than 20 reported cases in the literature. Objectives Adenoid ameloblastomas were identified after review of ameloblastomas from the University of Pittsburgh Medical Center Department of Pathology archives from 1990 to 2018. Findings A review of our archives yielded 6 cases of adenoid ameloblastoma in 5 patients. Of these, 2 tumors were obtained from the “in-house” pathology files with one tumor being a recurrent adenoid ameloblastoma, whereas the remaining were consultations. The 4 cases (in 3 patients) received in consultation had a differential diagnosis of a salivary neoplasm. All cases were in the maxilla (5/5, 100%), 60% were in males, with a mean age of 52.6 years (range 29-65), and mean size of 5.8 cm (range 4.0 to 7.8 cm). Increased mitotic activity was present in all cases, (mean 7 mitoses/10hpf, range 3-11 mitoses/10hpf). All tumors exhibited pseudoglandular spaces. Other common histologic features included whorls or morules, clear cells, ghost cells, and matrix production with hard tissue formation. Immunohistochemically, the tumors were positive for p63 (3/3, 100%), beta catenin within the morules (2/3, 66.6%), AE1/3 (1/1, 100%), CK5/6 (1/1, 100%), vimentin (1/1, 100%), CEA (2/2, 100%), p40 (1/1, 100%) and negative for BRAF V600E (0/3, 0%), calretinin (0/2, 0%), CK7 (0/1, 0%), SMA (0/4, 0%), S100 (0/3, 0%), Sox-10 (0/1, 0%), TTF-1(0/1, 0%), Pax-8 (0/1, 0%), p16 (0/1, 0%). Conclusions Adenoid ameloblastoma (with dentinoid) is a rare, aggressive odontogenic tumor variant with morphologic overlap with salivary neoplasms. Given the histologic similarities to other tumors and the high rate of recurrence, further characterization of this entity is needed