Prognosis of functional outcome after ischemic stroke is inuenced by a variety of factors already assessable in the acute phase and within the rst days after symptom onset. In clinical trials, stroke outcome is most commonly rated by the modied Rankin Scale (mRS)1 because of the validity and rapid application of this rating scale and its ability to discriminate clinically relevant levels of disability and recovery. A prospective observational study was done, in which 47 cases of acute ischemic stroke, thrombolysed after ruling out any bleed were included from March 2020 to October 2021. The demographics, risk factors, biochemical parameters and outcomes (mortality and complications) were assessed, until discharge or in-hospital death. Most common complication was Intra-cranial bleed that occurred in 7 (14.9%) patients following which was deterioration of power in 3 (6.4%) patients. Seizure and sepsis were reported in 2 (4.3%) patients each. Systemic hemorrhage was reported in 1 (2.1%) case. No patient reported thromboembolism. Favorable outcome according to Modied rankin scoring is 0-2 and out of 47 patients 29 patient showed favorable outcome in which 21 patients were anterior territory ischemic CVA while 8 were posterior territory. Total 3 patients out of 47 showed worst score of 6 i.e., death and 2 of them belonging to posterior territory.