The study is devoted to the problem of transforming the content of career guidance of school students in the current conditions in connection with the existing contradictions. The career guidance work of universities is associated both with solving the problem of recruiting applicants and with fulfilling the mission of the key subject of career guidance for students along with the school and employers. Conscious professional self-identification of school students at the present stage is possible due to the concerned position of these actors. Schools should be interested in their graduates choosing the optimal path for further education, the university is interested in obtaining a highly motivated applicant, employers interested in a specialist who is ready to adapt to work. The main components of career guidance at the school and university levels are presented. Career guidance should be systemic, including at the level of the educational organization. Derzhavin Tambov State University implements a “level” model of career guidance, which covers the levels of the educational program, department, institute/faculty, university. The characteristics of the activities implemented at the designated levels are given.