Career Exposure Research Articles

The Wear and Tear on Health: What is the Role of Occupation?

This discussion paper led to chapter Health and Inequality , pages 311-332 in: (P. Rosa Dias and O. O’Donnell (Eds)) Vol. 21 of 'Research on Economic Inequality', Emerald Group Publishing, 2013, 536 pages. While it seems evident that occupations affect health, effect estimates are scarce. We use a job characteristics matrix in order to characterize occupations by their physical and psychosocial burden in German panel data spanning 26 years. Employing a dynamic model to control for factors that simultaneously affect health and selection into occupation, we find that manual work and low job control both have a substantial negative effect on health that increases with age. The effects of late career exposure to high physical demands and low control at work are comparable to health deterioration due to aging by 16 and 23 months respectively.

The Role of PET with 13N-Ammonia and 18F-FDG in the Assessment of Myocardial Perfusion and Metabolism in Patients with Recent AMI and Intracoronary Stem Cell Injection

Over the last decade, the effects of stem cell therapy on cardiac repair after acute myocardial infarction (AMI) have been investigated with different imaging techniques. We evaluated a new imaging approach using (13)N-ammonia and (18)F-FDG PET for a combined analysis of cardiac perfusion, metabolism, and function in patients treated with intracoronary injection of endothelial progenitors or with conventional therapy for AMI. A total of 15 patients were randomly assigned to 3 groups based on different treatments (group A: bone marrow-derived stem cells; group B: peripheral blood-derived stem cells; group C: standard therapy alone). The number of scarred and viable segments, along with the infarct size and the extent of the viable area, were determined on a 9-segment (13)N-ammonia/(18)F-FDG PET polar map. Myocardial blood flow (MBF) was calculated for each segment on the ammonia polar map, whereas a global evaluation of left ventricular function was obtained by estimating left ventricular ejection fraction (LVEF) and end-diastolic volume, both derived from electrocardiography-gated (18)F-FDG images. Both intragroup and intergroup comparative analyses of the mean values of each parameter were performed at baseline and 3, 6, and 12 mo after AMI. During follow-up, major cardiac events were also registered. A significant decrease (P < 0.05) in the number of scarred segments and infarct size was observed in group A, along with an increase in MBF (P < 0.05) and a mild improvement in cardiac function. Lack of infarct size shrinkage in group B was associated with a marked impairment of MBF (P = 0.01) and cardiac dysfunction. Ambiguous changes in infarct size, MBF, and LVEF were found in group C. No differences in number of viable segments or in extent of viable area were found among the groups. At clinical follow-up, no major cardiac events occurred in group A patients, whereas 2 patients of group B experienced in-stent occlusion and one patient of group C received a transplant for heart failure. Our data suggest that a single nuclear imaging technique accurately analyzes changes in myocardial perfusion and metabolism occurring after stem cell transplantation.

Protecting Astronaut Health by Limiting Career Exposure to Space Radiation

Protecting Astronaut Health by Limiting Career Exposure to Space Radiation

Lung cancer mortality and fibre exposures among North Carolina asbestos textile workers

Objective:To describe mortality among workers exposed to chrysotile asbestos and evaluate the relationship between lung cancer and asbestos fibre exposure.Methods:Workers employed for at least 1 day between 1 January 1950...

The 21ST Century Accounting Career from the Perspective of the Malaysian University Students

Using questionnaire setting, this study examines the perception of the Malaysian public university students on the accounting career in Malaysia. This study seeks to identify the respondents’ preferred accounting career, their career exposure, the factors perceived to be important for an accountant and the acquisition qualities of an accountant. The results of this study provide interesting responses from the respondents. More respondents prefer to become a public accountant rather than holding a management post. The respondents obtained their career exposure mostly from the professional accounting bodies and the factors perceived to be most important in an accountant are work performance and self confidence. Salary is also one of the factors perceived to be important for an accountant. The respondents also perceived the essential qualities of an accountant are acquired through education. The results of this study provide insights to the bodies of accounting profession, employers and academics on the nature and relative importance of the factors deemed important for the accounting students in their employment decision and their preferences to employment opportunities.

Professionalizing the Postdoctoral Experience

The first postdoctoral association was launched in the United States 13 years ago. Although postdoctoral associations have made tremendous progress toward improving the lives of postdoctoral fellows, their job is not finished yet.

The under-representation of African Americans in animal welfare fields in the United States

This research explored possible reasons for the under-representation of African Americans in animal welfare fields. Semi-structured interviews of nine senior-level African Americans working in the animal welfare-related fields of veterinary medicine, nonprofit animal welfare organizations, animal shelters, and animal control revealed the following reasons: 1) economic disparities, 2) on-going civil rights struggle, 3) moral obligation to serve people, 4) unattractive career incentives, 5) inadequate career exposure and recruitment, 6) non-supportive environments, 7) negative images of the fields, 8) little or no positive animal experience, and 9) prejudice and discrimination. Participants objected to the suggestion of cultural differences in attitudes toward companion animals. All participants said increasing diversity in animal welfare fields was essential, and made suggestions for its increase.

Preclinical students: who are surgeons? 1

Background The purpose of the present study was to determine how preclinical medical students formulate their career choice and to determine the origin of negative perceptions regarding surgery as a career. Materials and methods A qualitative study was performed with second-year medical students voluntarily participating in focus group study. Students with and without an interest in surgery attended. Topics discussed included factors influencing career choice, priorities, perceptions, exposure, and interactions with surgeons. Three investigators conducted independent content analysis. Results Career choices for students interested in surgery originated primarily from premedical school experiences/interactions with surgeons. In contrast, students not interested in surgery made career choices during medical school and choices were shaped primarily by second-year preceptors. The main priority for students interested in surgery was personal happiness that was perceived as being significantly dependent upon career satisfaction. Students not interested in surgery tended to separate happiness derived from career versus family. Negative perceptions toward surgery were developed and reinforced by media, preceptors, and classmates. All students had minimal exposure to surgeons during preclinical years and generally agreed that increased involvement with surgeons would be beneficial, particularly through preclinical preceptorships. Conclusions Career choices of preclinical students interested in surgery were made prior to entering medical school, suggesting that outreach programs to high schools and colleges may beneficial. Negative perceptions about surgery develop through a variety of sources, including fellow classmates, preceptors, and the media. Surgeons need to take responsibility for these perceptions.

Case-cohort analysis of brain cancer and leukemia in electric utility workers using a refined magnetic field job-exposure matrix.

The potential association between occupational electric and magnetic field exposure and cancer is well documented in the literature, but there is uncertainty regarding a causal relation. Using data from a completed cohort study, we sought to refine the job-exposure matrix in a case-cohort analysis by regrouping jobs into more homogeneous groups, but without making additional measurements. From the original cohort, we selected the 164 men who died of leukemia, 145 men who died of brain cancer, and a random subcohort of 800 men (0.6% of the cohort). Erroneous job assignments were corrected and job groups were subdivided based on differences in work environments or tasks performed. Magnetic field exposure remained unrelated to leukemia mortality and positively associated with brain cancer mortality based on both cumulative and average magnetic field indices. Although not monotonic across the middle intervals, increased risk of brain cancer was found in relation to career exposure, with risk ratios of 1.8 (95% CI = 0.7-4.7) and 2.5 (95% CI = 1.0-6.3) in the uppermost categories for cumulative and average exposure, stronger for exposure 2-10 years past. Improvements in exposure assignment based only on reassignment of job titles to occupational categories had little impact on the measured associations of magnetic fields with leukemia or brain cancer.

Refinements in magnetic field exposure assignment for a case-cohort study of electrical utility workers.

This study examined the effect of refinements in exposure assignment on annual and career exposure to 60 Hz magnetic fields, using all deaths from brain cancer (145) and leukemia (164) and a random sample of 800 workers from a cohort of 138,905 men. Reassessment of 1060 job titles in the measurement database generated 20 subcategories in addition to 28 occupational categories used in the original cohort mortality study. Furthermore, previously misclassified jobs were corrected. The complete work history of each sub-cohort member was re-examined. Original and refined average annual exposures were 0.086 and 0.088 microT, respectively. The average career cumulative exposures were 1.40 and 1.44 microT-years, respectively. Spearman correlation coefficients between the original and refined methods across the companies were 0.81 for annual exposure and 0.93 for career cumulative exposure. 23% of the workers were assigned to another exposure ranking after refinement, but 85% of these moved to an adjacent group, suggesting that the differences in exposure ranking are small. The results of this study indicate that refinements have modest influence on the average annual and career exposures. However, the refinements may only change a very rough exposure assessment into one that is slightly less crude. The proportion of workers assigned to another exposure ranking indicated that nondifferential exposure misclassification in the original cohort mortality study may have occurred. Implications of these changes for the risk estimates of brain cancer and leukemia cases will to be examined.

Refinements in magnetic field exposure assignment for a case-cohort study of electrical utility workers

This study examined the effect of refinements in exposure assignment on annual and career exposure to 60 Hz magnetic fields, using all deaths from brain cancer (145) and leukemia (164) and a random sample of 800 workers from a cohort of 138 905 men. Reassessment of 1060 job titles in the measurement database generated 20 subcategories in addition to 28 occupational categories used in the original cohort mortality study. Furthermore, previously misclassified jobs were corrected. The complete work history of each sub-cohort member was re-examined. Original and refined average annual exposures were 0.086 and 0.088 μT, respectively. The average career cumulative exposures were 1.40 and 1.44 μT-years, respectively. Spearman correlation coefficients between the original and refined methods across the companies were 0.81 for annual exposure and 0.93 for career cumulative exposure. 23% of the workers were assigned to another exposure ranking after refinement, but 85% of these moved to an adjacent group, suggesting that the differences in exposure ranking are small. The results of this study indicate that refinements have modest influence on the average annual and career exposures. However, the refinements may only change a very rough exposure assessment into one that is slightly less crude. The proportion of workers assigned to another exposure ranking indicated that nondifferential exposure misclassification in the original cohort mortality study may have occurred. Implications of these changes for the risk estimates of brain cancer and leukemia cases will to be examined.

Initiation-promotion model of tumor prevalence in mice from space radiation exposures.

Exposures in space consist of low-level background components from galactic cosmic rays (GCR), occasional intense-energetic solar-particle events, periodic passes through geomagnetic-trapped radiation, and exposure from possible onboard nuclear-propulsion engines. Risk models for astronaut exposure from such diverse components and modalities must be developed to assure adequate protection in future NASA missions. The low-level background exposures (GCR), including relativistic heavy ions (HZE), will be the ultimate limiting factor for astronaut career exposure. We consider herein a two-mutation, initiation-promotion, radiation-carcinogenesis model in mice in which the initiation stage is represented by a linear kinetics model of cellular repair/misrepair, including the track-structure model for heavy ion action cross-sections. The model is validated by comparison with the harderian gland tumor experiments of Alpen et al. for various ion beams. We apply the initiation-promotion model to exposures from galactic cosmic rays, using models of the cosmic-ray environment and heavy ion transport, and consider the effects of the age of the mice prior to and after the exposure and of the length of time in space on predictions of relative risk. Our results indicate that biophysical models of age-dependent radiation hazard will provide a better understanding of GCR risk than models that rely strictly on estimates of the initial slopes of these radiations.

Conscientious neurologists treat in-flight epilepsy.

What is the likelihood that a neurologist would be asked to help manage an epileptic attack in one of the 500 million Americans expected to fly next year? During a 30-year career exposure, we calculate the risks to vary widely between 4% and 60%, depending on plane size, the recreational attitudes and ages of fellow travelers, and flight durations. Long flights with elderly travelers to small medical centers are riskier. We endorse samaritanism. Quick differential diagnosis may be the most valuable contribution. We do not suggest that physicians carry antiepileptic medications. ( Arch Neurol . 1994;51:519-520)

Breaking the barriers: helping female and minority students succeed in mathematics and science

Breaking the Barriers shows how increased career awareness and exposure to mentors and role models can help students see science and math-related careers as desirable and viable options. It explains how test preparation, activity-based instruction, cooperative learning, and tutoring can help to improve academic outcomes.

A career exposure program for the physically handicapped

A career exposure program for the physically handicapped