BackgroundConsidering the weakening of the economy and the shrinkage of jobs under the current global epidemic crisis, the employment of college graduates is facing unprecedented and cruel competition. However, many college students lack a reasonable understanding and orientation of themselves, which leads to them having high expectations for future careers and not considering whether they are competent or not. Due to a lack of ability and self-confidence, they appear to be at a loss and hesitant when facing career choices. Therefore, the purpose of this study is to explore the relationship between perfectionism, career adaptability and career decision-making difficulties from both positive and negative aspects.MethodsWe sampled 400 college students in China and used a questionnaire to obtain cross-sectional data through the Perfectionism, Career Adaptability, and Career Decision Difficulties scales. This study explored the relationship between them using statistical analysis software such as SPSS and AMOS through the results of correlation analysis and mediating role analysis.ResultsCollege students’ perfectionism, career adaptability, and career decision-making difficulties were significantly correlated (p < 0.01). Positive perfectionism has a negative predictive effect on career decision-making difficulties, and career adaptability plays a completely mediating role in it (the direct effect is −0.032, the mediation effect is −0.244, and the total effect is −0.276.). Negative perfectionism plays a positive predictive role in career decision-making difficulties, and career adaptability plays a part in mediating roles (the direct effect is 0.334, the mediating effect is 0.099, and the total effect is 0.433.).ConclusionsCollege students will more or less pursue “perfect”, but often with their own preferences to pursue, cannot be done based on the rational analysis of things to pursue perfect. College students have higher positive perfectionism and negative perfectionism, and their career adaptability is also at a higher level, but there is a higher degree of career decision-making difficulties. Positive perfectionism of college students can reduce the difficulty of career decision-making, and career adaptability plays a completely mediating role in it. Negative perfectionism of college students will lead to difficulties in career decision-making, in which career adaptability plays a mediating role.