Following the increasing rate of Cardiovascular diseases, actions have been taken and geared towards the discovery of new leads (drugs) since the existing drugs treat and manage some of these Cardiovascular ailments but with proven adverse effects on the side of the patients. Coronary artery disease which is also called Ischemic heart disease is a crucial problem worldwide, and it's known as a major non-transmissible disease. A good example of ischemic heart disease is acute myocardial infarction (MI), and its manifest due to inequality between coronary blood supply and myocardial demand. Sustained ischemia causes myocardial infarction, which leads to myocardial cell death. Cardiac biomarkers are enzymes/proteins that are used as essential tools in cardiology for primary and secondary prevention, diagnosis and management of acute myocardial infarction and other heart-related issues. The treatment and management of diseases in the African continent are achieved mostly with traditional medicine, and Plants are known to contain active components which possess medical properties that are harnessed for the treatment of different diseases. So many medicinal plants have shown to be potent in the treatment and management of this life-threatening condition known as acute myocardial infarction (heart attack). Some research-proven cardioprotective plants and possible tools for evaluating their potency are reviews in this article.