Abstract
Jasminum sambac (L.) is a South Asian folkloric medicinal plant that has traditionally been used to treat cardiovascular problems. The current investigation was meticulously organized to explore the pharmacological foundation for the medicinal uses of J. sambac pertaining to cardiovascular ailments and to investigate the core mechanisms. Mechanistic investigation revealed that crude leaf extract of J. sambac produced ex-vivo vasorelaxant effects in endotheliumintact aorta ring preparation and hypotensive effect was recorded via pressure and force transducers coupled to the Power Lab Data Acquisition System. Moreover; J. sambac showed cardioprotective effects against adrenaline -induced left ventricular hypertrophy in rabbits observed hemodynamic. CK-MB, LDH, troponin, CRP, ALT, AST, ALP levels were shown to be lower in the myocardial infarction model, as were necrosis, oedema, and inflammatory cell recruitment in comparison to control. J. sambac has shown good antioxidant potential as well as prolonged the noradrenaline induced platelet adhesion. The vasorelaxant and cardioprotective effects in both in vivo and ex vivo experiments, which are enabled by activation of muscarinic receptor and/or releasing the nitric oxide and by reducing the adrenaline, induced oxidative stress, justifying its usage in cardiovascular disorders.
Highlights
It is logical to believe that the cardioprotective effect of J. sambac in rabbits might depend on the presence of these flavonoids
The hydroalcoholic leaf extract of J. sambac was seen to produce vasorelaxant/ hypotensive effect during ex-vivo study via stimulating the muscarinic receptors and/or releasing the local vasodilators NO
The cardioprotective effect of hydroalcoholic leaf extract J. sambac may be due to its variety of phytoconstituents
Summary
Adrenaline is a non-selective agonist of all adrenergic receptors consisting of alpha, beta and their subtypes primarily located on the cardiovascular system [6]. It causes myocardial infarction above the therapeutic dose (2 mg/kg body weight) [6]. This method is applied to induce myocardial infarction in the experimental animal to evaluate the cardioprotective effect of test drugs. It causes myocardial infarction because of lipid peroxidation that leads to the depletion of cellular antioxidants. The present study was to see if hydroalcoholic leaf extract of J. sambac had any cardioprotective properties
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