Cardiopulmonary Comorbidities Research Articles

Endothelial (dys)function in lone atrial fibrillation.

Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia in adult population and confers significant thromboembolic risk. Endothelial dysfunction has been recognized as a possible contributor to thrombogenesis in AF. The arrhythmia has been associated with thrombogenic atrial endocardial lesions and evidence of increased circulating biomarkers of endothelial dysfunction (e.g. von Willebrand factor, soluble thrombomodulin, E-selectin, asymmetric dimethylarginine, circulating endothelial cells and microparticles), and impairment of endothelium-dependent vasodilatation in the peripheral and coronary circulation has been reported in AF patients. Increased levels of biomarkers of endothelial origin (e.g. von Willebrand factor, soluble thrombomodulin, E-selectin, asymmetric dimethylarginine) have been associated with adverse outcomes in AF patients. Importantly, endothelial dysfunction has been documented in AF patients without cardio-pulmonary comorbidities or risk factors (so-called 'lone AF'), as well. In this review, we provide an overview of contemporary evidence for the alterations in endothelial function and endothelial injury in AF, with a focus on endothelial (dys)function in lone AF.

From open surgery to uniportal VATS: asturias experience.

Uniportal video-assisted thoracic surgery (VATS) resections are of increasing interest in many thoracic surgery departments. This study shows our initial experience in uniportal VATS anatomical resections in direct transition from posterolateral thoracotomy. We retrospectively reviewed the 82 files of patients on whom anatomical pulmonary resection via uniportal VATS was attempted in our department by a single surgeon experienced in VATS for almost all purposes except major pulmonary resections. Demographic data of patients, smoking habits, chronic obstructive pulmonary disease (COPD), presence of cardiopulmonary comorbidities, general characteristics of pulmonary lesions, preoperative FEV1, intraoperative findings, operative time, postoperative-drain-time, hospital-stay-time, successfully completed or converted to thoracotomy, intraoperative and postoperative complications and 30-day mortality were recorded. The patients were chronologically divided into two groups for analysis (A: operated on in the first year; B: operated on after the first year). We compare our results with the largest published experience in anatomical resections by uniportal VATS started from multiport technique and anterior thoracotomy in order to identify the feasibility of this transition. From January 2012 to January 2014, 82 uniportal VATS anatomical pulmonary resections were attempted. Of these 82 resections attempted, 74 (90.2%) were completely carried out. The median drain-time and hospital-stay-time were 3 days, and 4 days for the first year of experience and 2 and 3 days for the second year of experience respectively. The most frequent intraoperative complication was bleeding in 10 (12.1%), of these 8 occurred in the first year of experience (group A). In 8 (9.75%) cases conversion to thoracotomy widening the incision was needed for different reasons, of these 6 occurred in group A. The most frequent minor complication was chest tube reinsertion in 12 (14.6%) patients. There were no major complications or mortality in the first year of experience (group A). Two cases of mortality in the 8(th) and 15(th) postoperative day respectively occurred in group B in two patients with serious comorbidities. Uniportal VATS for anatomical resections is a feasible and safe technique with good results even if experience is started in direct transition from open surgery, on condition that general recommendations for an initial VATS program were observed. Specific training courses with experts are also necessary. Patient selection is crucial. The number of procedures necessary to obtain appropriate experience may be similar to those reported for transition from open surgery to multiport technique.

Avoiding Complications from Arthroplasty and Anticoagulation.

Achieving the right balance with blood coagulability is tricky before, during, and after joint arthroplasty. Both excessive bleeding and embolic events can lead to catastrophic complications or fatalities. Established coagulation guidelines related to joint arthroplasty are useful for surgeons and other clinicians, but getting the hematology “just right” for individual arthroplasty patients is both a science and an art that often requires multidisciplinary consultations. We present a number of complications arising from the management of anticoagulation parameters in joint replacement patients; these cases focus on the need for vigilance and clinical observation coupled with the importance of monitoring laboratory values. In the July 23, 2014 edition of JBJS Case Connector , Wang et al. describe the case of an eighty-three-year-old man who developed severe skin and soft-tissue necrosis after total knee arthroplasty (TKA), a rare complication that eventually resulted in an above-the-knee amputation. Like many patients nowadays, he had been on chronic warfarin therapy to reduce the risk of blood clots from atrial fibrillation. The warfarin had been withheld six days prior to the knee replacement. After the procedure, he received enoxaparin while hospitalized, and the warfarin therapy was resumed. He was discharged on postoperative day three. The day after discharge, the patient presented to the emergency department with pain that was limiting mobility. Examination revealed a swollen knee and hemorrhagic blisters around the surgical site. Blistering spread over the next two days, and the bullae were drained at the bedside. By postoperative day seven, there were new blisters, and the skin beneath the older blisters appeared dark. Warfarin was discontinued the following day when the patient’s international normalized ratio (INR) peaked at 2.4. The blisters continued to enlarge until …

ISMAR-study presentation: in-hospital epidemiology and clinical management of respiratory and cardiac comorbidities in cardiac and respiratory disease units.

BackgroundCardiovascular and respiratory diseases are leading causes of morbidity and their co-occurrence has important implications in mortality and other outcomes. Even the most recent guidelines do not reliably address clinical, prognostic, and therapeutic concerns due to the overlap of respiratory and cardiac diseases.Study objectives and designIn order to evaluate in the reality of clinical practice the epidemiology and the reciprocal impact of cardio-pulmonary comorbidity on the clinical management, diagnostic workup and treatment, 1,500 cardiac and 1,500 respiratory inpatients, admitted in acute and rehabilitation units, will be enrolled in a multicenter, nationwide, prospective observational study.For this purpose, each center will enroll at least 50 consecutive patients. At discharge, data analysis will be aimed at the definition of cardiac and pulmonary inpatient comorbidity prevalence, demographic characteristics, length of hospital stay, and risk factors, taking into account also procedures, pharmacological and non-pharmacological treatment, and follow up in patients with cardio-respiratory comorbidity.ConclusionsThe purely observational design of the study aims to give new relevant information on the assessment and management of overlapping patients in real life clinical practice, and new insight for improvement and implementation of current guidelines on the management of individual diseases.

ISMAR-study presentation: in-hospital epidemiology and clinical management of respiratory and cardiac comorbidities in cardiac and respiratory disease units


 
 
 
 Background: Cardiovascular and respiratory diseases are leading causes of morbidity and their co-occurrence has important implications in mortality and other outcomes. Even the most recent guidelines do not reliably address clinical, prognostic, and therapeutic concerns due to the overlap of respiratory and cardiac diseases.
 Study objectives and design: In order to evaluate in the reality of clinical practice the epidemiology and the reciprocal impact of cardio-pulmonary comorbidity on the clinical management, diagnostic workup and treatment, 1,500 cardiac and 1,500 respiratory inpatients, admitted in acute and rehabilitation units, will be enrolled in a multicenter, nationwide, prospective observational study. For this purpose, each center will enroll at least 50 consecutive patients. At discharge, data analysis will be aimed at the definition of cardiac and pulmonary inpatient comorbidity prevalence, demographic characteristics, length of hospital stay, and risk factors, taking into account also procedures, pharmacological and non-pharmacological treatment, and follow up in patients with cardio-respiratory comorbidity.
 Conclusions: The purely observational design of the study aims to give new relevant information on the assessment and management of overlapping patients in real life clinical practice, and new insight for improvement and implementation of current guidelines on the management of individual diseases.
 
 
 

Surgeon-Modified Fenestrated Endograft to Treat Ruptured Juxtarenal Aneurysm

No endovascular devices are commercially available in the United States to treat high-surgical risk patients with aneurysms extending to visceral arteries. Treatment options are even further limited for symptomatic patients in need of urgent treatment. To describe a successful urgent endovascular repair of a juxtarenal abdominal aortic aneurysm with contained rupture. A hybrid suite using a surgeon-modified fenestrated endovascular graft and advanced 3-dimensional imaging workstation. The patient was an 82-year-old veteran taking clopidogrel and aspirin for coronary stents with significant cardiopulmonary comorbidities including multiple prior abdominal surgeries and a single functional left kidney. Surgeon-modified fenestrated endovascular aortic aneurysm repair. Clinical, laboratory, and radiographic improvement. The patient was discharged 5 days after an uneventful postoperative course. On short-term follow-up, the patient had an early return to his baseline functional status. The excluded aneurysm sac shrank with patent visceral branches and there was an absence of endoleak on 3-month and 6-month surveillance computed tomography angiography. Surgeon-modified fenestrated stent grafts may be a viable option for selected high-surgical risk patients with symptomatic complex abdominal aortic aneurysms.

Midterm Outcomes After Prearteriotomy Guidewire Access (PAGA) With Antegrade Recanalization in Patients With Extensive Aortoiliofemoral Occlusive Disease Without the Use of a Re-entry Device

A prearteriotomy guidewire access (PAGA) was described to treat bulky iliofemoral occlusive disease. A wire is passed first from the groin into the aorta, before the arteriotomy, to increase technical success. Achieving retrograde intraluminal access in extensive aortoiliofemoral occlusive disease (AIFOD) can be a challenge. We modified the PAGA technique to successfully recanalize extensive aortoiliofemoral occlusion performed with adjunctive femoral artery reconstruction as an alternative to extra-anatomic bypass in high-risk patients for aortobifemoral bypass. We approach these cases via a left brachial approach and groin cutdown. Once brachial access is obtained, the patient is systematically heparinized. Then, a 90-cm destination sheath is placed in the distal aorta. A stiff glidewire and a guide catheter are used to recanalize the chronic AIFOD. The wire is passed in an antegrade fashion across the AIFOD all the way toward the femoral head. A femoral arteriotomy is done to capture the wire, thus establishing access from the groin into the patent aorta. External iliac artery and femoral artery endarterectomy is performed around the wire. The wire is passed through the patch before the patch angioplasty is completed. Once femoral revascularization is done, a sheath is placed over the wire, and retrograde iliac stenting is performed to the level above the patch to avoid crossing the inguinal ligament. This procedure has been performed in 18 patients (13 with critical limb ischemia, 5 with claudication) with 94.4% technical success, without the use of a re-entry device. Four patients required an interposition graft, and 14 (77.8%) required femoral endarterectomy with patch angioplasty. The procedures in 10 patients (55.5%) were done under spinal anesthesia. All patients had significant cardiopulmonary comorbidities, and five had had multiple abdominal surgeries. One patient (5.5%) required oral antibiotics to treat a superficial wound infection. One patient (5.5%) died ≤30 days (massive myocardial infarction), and one patient required an axillobifemoral bypass at 6 months for acute stent occlusion. The remaining 17 patients were symptom free, with patent stents, at a mean of 16.5 months (range, 12-22 months). Modified PAGA can be used to safely revascularize high-risk patients with extensive AIFOD, with acceptable complication rate and patency. This procedure is currently offered to patients with aortoiliofemoral disease, not candidates for aortobifemoral bypass, instead of an extra-anatomic bypass.

Does the Impact of the Type of Anesthesia on Outcomes Differ by Patient Age and Comorbidity Burden?

Neuraxial anesthesia may provide perioperative outcome benefits versus general anesthesia in orthopedic surgical patients. As subgroup analyses are lacking, we evaluated the influence of the type of anesthesia on outcomes in patient groups of different age and the presence of cardiopulmonary disease. Data from approximately 500 hospitals in the United States regarding total hip and total knee arthroplasties performed between 2006 and 2012 were accessed. Patients were categorized by age (ie, <65, 65-74, or ≥75 years) as well as the presence of cardiopulmonary disease. Resulting groups were compared with regard to patient, hospital, procedure, and comorbidity-related variables, as well as incidence of major perioperative complications. A multivariable logistic regression analysis was performed to assess the independent influence of the type of anesthesia on complications within each patient subgroup. We identified 795,135 records of patients who underwent total hip arthroplasty or total knee arthroplasty. The incidence of major complications was highest in the oldest patient group with cardiopulmonary disease (26.1%) and the lowest in the youngest group without cardiopulmonary disease (4.5%).Multivariable logistic regressions showed that neuraxial anesthesia was associated with decreased odds for combined major complications, need for intensive care services, and prolonged length of stay compared with general anesthesia in all patient subgroups. For patients without major cardiopulmonary comorbidities, the positive impact of neuraxial anesthesia increased with increasing age. Neuraxial anesthesia is associated with decreased odds for major complications and resource utilization after joint arthroplasty for all patient groups, irrespective of age and comorbidity burden.

First UK Transvaginal NOTES-Assisted Sigmoid Colectomy

Abstract Introduction: Natural orifice translumenal endoscopic surgery (NOTES) is moving into the clinical arena with multiple feasibility trials taking place around the world. Early results appear encouraging, and the transvaginal access route appears most favoured due to its established safety parameters in gynecological surgery. Following extensive simulator, ex vivo, in vivo, and clinical research and following a successful trial of hybrid NOTES cholecystectomy, ethical approval was granted to evaluate the feasibility and clinical outcomes of transvaginal NOTES-assisted sigmoid colectomy at Imperial College. Methods: A 63-year-old woman who had been admitted to hospital on three occasions with radiologically confirmed diverticulitis was counseled for inclusion in the trial. The patient had previously undergone laparoscopic sterilization, but had no major cardiopulmonary comorbidities. Results: On the 24th of February 2012, the patient underwent the first UK transvaginal NOTES-assisted sigmoid colectom...

Effects of Immunocompromise and Comorbidities on Pneumococcal Serotypes Causing Invasive Respiratory Infection in Adults: Implications for Vaccine Strategies

The 13-valent pneumococcal conjugate vaccine (PCV13) has recently been approved for use in immunocompromised adults. However, it is unclear whether there is an association between specific underlying conditions and infection by individual serotypes. The objective was to determine the prevalence of serotypes covered by PCV13 in a cohort of patients with invasive pneumococcal disease of respiratory origin and to determine whether there are specific risk factors for each serotype. An observational study of adults hospitalized with invasive pneumococcal disease in 2 Spanish hospitals was conducted during the period 1996-2011. A multinomial regression analysis was performed to identify conditions associated with infection by specific serotypes (grouped according their formulation in vaccines and individually). A total of 1094 patients were enrolled; the infecting serotype was determined in 993. In immunocompromised patients, 64% of infecting serotypes were covered by PCV13. After adjusting for age, smoking, alcohol abuse, and nonimmunocompromising comorbidities, the group of serotypes not included in either PCV13 or PPV23 were more frequently isolated in patients with immunocompromising conditions and cardiopulmonary comorbidities. Regarding individual serotypes, 6A, 23F, 11A, and 33F were isolated more frequently in patients with immunocompromise and specifically in some of their subgroups. The subgroup analysis showed that serotype10A was also associated with HIV infection. Specific factors related to immunocompromise seem to determine the appearance of invasive infection by specific pneumococcal serotypes. Although the coverage of serotypes in the 13-valent conjugate pneumococcal vaccine (PCV13) was high, some non-PCV13-emergent serotypes are more prevalent in immunocompromised patients.

Clinical Impact of Isolated Infrarenal Aortic Stenosis

Objectives: To evaluate early outcomes and short-term durability of thoracic stent cuffs in patients with abdominal aortic aneurysms (AAA) and infrarenal necks too large for standard endovascular aneurysm repair (EVAR) who were symptomatic, not suitable for open surgery, and could not wait for a custom fenestrated device to be created. Methods: From July 2010 to December 2012, 13 patients with juxtaor pararenal AAA underwent endovascular repair with thoracic aortic endografts as proximal aortic cuffs in conjunction with standard EVAR devices. The patients were symptomatic and were deemed unfit for open surgery due to severe cardiopulmonary and/or renal comorbidities. All patients had infrarenal neck diameters greater than the indications for use for standard aortic endografts. Primary end points were technical success (as defined by aneurysm exclusion without endoleak), follow-up aneurysm exclusion by computed tomographic angiogram, and 30-day and longterm mortality. Results: Thirteen patients (10 men, 3 women) with a mean age of 77.1 years underwent EVAR who presented with symptomatic juxtaor pararenal abdominal aortic aneurysms. The mean aneurysm size was 7.2 cm, and the mean infrarenal aortic neck diameter was 35.5 mm measured by centerline analysis. Technical success was achieved in 100% of cases. The 30-day mortality was 8% (one of 13 patients). At a mean follow-up of 524 days, there have been no endoleaks or other aneurysm related mortalities. There was one death due to stroke at 605 days postop. Conclusions: Complex endovascular repair of juxta and pararenal AAA using thoracic stents cuffs can be safely and successfully performed in symptomatic patients medically unfit for open repair. Using thoracic stent cuffs below the visceral vessels may reduce the complexity and possibly the risk of repair when compared with fenestrated endografts. These techniques can be used for urgent and emergent cases where the wait time for fenestrated technology is prohibitive. Although our results have demonstrated short-term success, long-term durability of this technique with further evaluation is required.

Surgery for nonsmall cell lung cancer.

Surgery remains the best curative option in patients with early stage lung cancer (stage I and II). Developments in minimally invasive techniques now allow surgeons to perform lung resections on elderly patients, patients with poor pulmonary function or significant cardiopulmonary comorbidities. New techniques, such as stereotactic radiotherapy and ablative procedures, are being evaluated in early-stage lung cancer and may represent an alternative to surgery in patients unfit for lung resection. Perioperative mortality rates have dropped significantly at most institutions in the past two decades and complications are managed more efficiently. Progress in imaging and staging techniques have helped cut futile thoracotomy rates and offer patients the most adequate treatment options. Large randomised trials have helped clarify the role of neoadjuvant, induction and adjuvant chemotherapy, as well as radiotherapy. Surgery remains an essential step in the multimodality therapy of selected patients with advanced-stage lung cancer (stage III and IV). Interventional and endoscopic techniques have reduced the role of surgery in the diagnosis and staging of nonsmall cell lung cancer, but surgery remains an important tool in the palliation of advanced-stage lung cancer. Large national/international surgical databases have been developed and predictive risk-models for surgical mortality/morbidity published by learned surgical societies. Nonetheless, lung cancer overall survival rates remain deceptively low and it is hoped that early detection/screening, better understanding of tumour biology and development of biomarkers, and development of efficient targeted therapies will help improve the prognosis of lung cancer patients in the next decade.

Effectiveness of Automated Quantification of Pulmonary Perfused Blood Volume Using Dual-Energy CTPA for the Severity Assessment of Acute Pulmonary Embolism

The purpose of this study was to determine whether automated quantification of pulmonary perfused blood volume (PBV) in dual-energy computed tomography pulmonary angiography is of diagnostic value in assessing the severity of acute pulmonary embolism (PE). Ethical approval and informed consent were waived by the responsible institutional review board for this retrospective study. Of 224 consecutive patients with dual-energy computed tomography pulmonary angiographic findings positive for acute PE, we excluded 153 patients because of thoracic comorbidities (n = 130), missing data (n = 11), severe artifacts (n = 11), or inadequate enhancement (n = 1). Automated quantification of PBV was performed in the remaining 71 patients (mean [SD] age, 62 [16] years) with acute PE and no cardiopulmonary comorbidities. Perfused blood volume values adjusted for age and sex were correlated with the Qanadli obstruction score, morphological computed tomographic signs of right heart dysfunction, serum levels of troponin, and the necessity for intensive care unit (ICU) admission. Dual-energy computed tomography pulmonary angiography-derived PBV values inversely correlated with the Qanadli score (r = -0.46; P < 0.001), the right and left ventricle (RV/LV) ratio (r = -0.52; P < 0.001), and troponin I (r = -0.45; P = 0.001). The patients with global PBV values lower than 60% were significantly more likely to require admission to an ICU than did the patients with global pulmonary PBV of 60% or higher (47% vs 11%; P = 0.003; positive predictive value, 47%; negative predictive value, 89%). On the univariate analysis, a significant negative correlation was found between the global PBV values and the Qanadli obstruction score (r = -0.46; P < 0.001), the RV/LV diameter ratio (r = -0.52; P < 0.001), and the necessity for ICU admission (r = -0.39; P = 0.001). On the retrospective multivariate regression analysis, the areas under the receiver operating characteristic curve for the prediction of ICU admission were 0.75 for the pulmonary PBV, 0.83 for the Qanadli obstruction score, 0.68 for the computed tomographic signs of right heart dysfunction (interventricular septal bowing and/or contrast reflux), and 0.76 for the RV/LV diameter ratio. Dual-energy computed tomography pulmonary angiography can be used for an immediate, reader-independent estimation of global pulmonary PBV in acute PE, which inversely correlates with thrombus load, laboratory parameters of PE severity, and the necessity for ICU admission.

Video-assisted thoracoscopic superior segmentectomy of the right lower lobe.

Sublobar resections are still controversial for lung cancer, but for patients who can't tolerate lobectomy, such as those suffering from cardiopulmonary comorbidities and aged people, sublobar resections are better choices. Lobectomy and sublobar resections have similar surgical effect on patients with tumors ≤2 cm. A 64-year-old patient with chronic obstructive pulmonary disease (COPD) and poor pulmonary function on pre-operation evaluation underwent thoracoscopic superior segementectomy with systemic mediastinal lymph node dissection. Three holes were adopted, the major operation hole was a 3 cm mini-incision in the 4(th) intercostal space of anterior axillary line. The patient has recovered well after the surgery.

Efficacy of laparoscopic radiofrequency ablation for the treatment of patients with small solitary colorectal liver metastasis

Although radiofrequency ablation (RFA) has been incorporated to the treatment algorithm of patients with unresectable colorectal liver metastasis (CLM), its utility in patients with resectable disease has not been well studied. The aims of this study were to define the clinical profile of patients with a solitary CLM who underwent laparoscopic RFA and to analyze their oncologic outcomes. Between 2000 and 2011, 44 patients underwent laparoscopic RFA and 60 patients resection of solitary CLM ≤3 cm. Data were analyzed from a prospectively maintained institutional review board-approved database using Student's t test, Chi-square, and Kaplan-Meier tests. The indications for RFA were patient decision in 61% (n = 27), comorbidities in 34% (n = 15), and intraoperative findings in 5% (n = 2). In comparison with the resection group, RFA patients had a greater American Society of Anesthesiologists score (3.0 ± 0.1 vs 2.6 ± 0.1, respectively; P = .002), more frequent incidence of cardiopulmonary comorbidities (60% vs 38%, respectively; P = .045), and tumors located deeper in the liver parenchyma (39% vs 12%) that would have required a formal lobectomy. The 2groups were otherwise similar for age, gender, carcinoembrradyogenic antigen, synchronous versus metachronous presentation of CLM, tumor size, and tumor and nodal status of primary colorectal cancer. The local recurrence rate was 18% after RFA and 4% after resection (P = .012). The overall Kaplan-Meier, cancer-specific, 5-year survival was 47% for RFA and 57% for resection (P = .464). Median disease-free survival was 25 months after RFA and 22 months after resection (P = .973). Our results suggest that laparoscopic RFA might spare a number of patients at greater risk with a small solitary CLM the risk of morbidity from a formal liver resection. Furthermore, laparoscopic RFA might also be acceptable as the first line of therapy for patients with tumors that otherwise would have required a formal lobectomy or open resection. Nevertheless, the local recurrence rate of RFA should be kept in mind and the patients followed closely to treat failures promptly.

Family history, comorbidity and risk of thoracic aortic disease: a population-based case-control study

ObjectiveTo examine the risk of thoracic aortic disease (TAD) when one or more first-degree relatives are affected, and to relate the risk of family history to the risk of other...

Venous Thromboembolism After Joint Replacement in Older Male Veterans with Comorbidity

To identify older adults with comorbidities or poor functional status at high risk of postoperative venous thromboembolism (VTE). Retrospective cohort study. Veterans Affairs Medical Center (VAMC). Older adults who underwent total hip and knee replacement (THR and TKR) from 2002 to 2009. Using multivariate logistic regression, the independent effect of cardiopulmonary comorbidities and diabetes on VTE was analyzed. Functional status expressed in a summary physical component score (PCS) was also analyzed in a subset of individuals in whom information on it was available. There were 23,326 THR and TKR surgeries performed at the VAMC during the study period. Individuals with chronic obstructive pulmonary disease (COPD) had a 25% greater risk of VTE (odds ratio (OR)=1.25, 95% confidence interval (CI)=1.06-1.48), whereas those with coronary artery disease, congestive heart failure, and cerebrovascular disease did not have a greater risk of VTE. Individuals with diabetes mellitus had a lower risk of VTE (OR=0.77, 95% CI=0.64-0.92). Individuals with low PCS, which were available for 3,169 patients, had a 62% greater risk, although the effect did not reach statistical significance (lowest vs highest quartile OR=1.62, 95% CI=0.93-2.80). Individuals with COPD had slightly greater risk of VTE, whereas low functional status had a larger effect that did not reach statistical significance. The constraints of administrative data analysis and sample size available for PCS limit conclusions about the role of these comorbidities and functional status.

Assessing Pulmonary Perfusion in Emphysema

The objective of this study was to determine whether automated quantification of lung perfused blood volume (PBV) in dual-energy computed tomographic pulmonary angiography (DE-CTPA) can be used to assess the severity and regional distribution of pulmonary hypoperfusion in emphysema. We retrospectively analyzed 40 consecutive patients (mean age, 67 [13] years) with pulmonary emphysema, who have no cardiopulmonary comorbidities, and a DE-CTPA negative for pulmonary embolism. Automated quantification of global and regional pulmonary PBV was performed using the syngo Dual Energy application (Siemens Healthcare). Similarly, the global and regional degrees of parenchymal hypodensity were assessed automatically as the percentage of voxels with a computed tomographic density less than -900 Hounsfield unit. Emphysema severity was rated visually, and pulmonary function tests were obtained by chart review, if available. Global PBV generated by automated quantification of pulmonary PBV in the DE-CTPA data sets showed a moderately strong but highly significant negative correlation with residual volume in percentage of the predicted residual volume (r = -0.62; P = 0.002; n = 23) and a positive correlation with forced expiratory volume in 1 second in percentage of the predicted forced expiratory volume in 1 second (r = 0.67; P < 0.001; n = 23). Global PBV values strongly correlated with diffusing lung capacity for carbon monoxide (r = 0.80; P < 0.001; n = 15). Pulmonary PBV values decreased with visual emphysema severity (r = -0.46, P = 0.003, n = 40). Moderate negative correlations were found between global PBV values and parenchymal hypodensity both in a per-patient (r = -0.63; P < 0.001; n = 40) and per-region analyses (r = -0.62; P < 0.001; n = 40). Dual-energy computed tomographic pulmonary angiography allows simultaneous assessment of lung morphology, parenchymal density, and pulmonary PBV. In patients with pulmonary emphysema, automated quantification of pulmonary PBV in DE-CTPA can be used for a quick, reader-independent estimation of global and regional pulmonary perfusion, which correlates with several lung function parameters.

Impaired endothelial function in lone atrial fibrillation

Impaired endothelial function has been previously documented in patients with atrial fibrillation (AF) and underlying comorbidities or older patients with idiopathic AF. The aim of this study was to evaluate systemic endothelial function in younger AF patients (less than < 60 years old) with lone AF (that is, without associated cardiopulmonary comorbidities, including arterial hypertension), by comparing brachial artery flow-mediated dilation (FMD) in lone AF patients with FMD of healthy subjects in sinus rhythm. Two groups of participants were prospectively enrolled. The first group comprised of 38 AF patients (the mean age 45 +/- 11 years, 68% male) with persistent (> 7 days) lone AF. The second group comprised of 28 healthy controls in sinus rhythm (the mean age 43 +/- 13, 53% male), matched by age, gender and atherosclerotic risk factors. All the participants underwent physical examination, laboratory analysis [including determination of C-reactive protein (CRP)], standard echocardiography and exercise-stress testing. Brachial artery FMD and endothelium independent dilation (NMD) were assessed with a high-resolution ultrasound probe and arterial diameters taken from 5 consecutive cardiac cycles were averaged for each measurement to accommodate to beat-to-beat flow variations in AF. There were no differences between the 2 groups regarding age, gender and most clinical, laboratory and echocardiographic characteristics (all p > 0.05), apart from the increased heart rate (p = 0.018), body mass index (p = 0.027), CRP levels (p = 0.007) and left atrial anteroposterior dimension (p < 0.001) in AF patients. FMD of AF patients [median value 5.0%, interquartile range (IQR) 2.87%-7.50%] was significantly lower (p < 0.001) than FMD of healthy controls (median value 8.85%, IQR 5.80%-12.50%), whereas there were no differences in median NMD values (p > 0.05). In the multivariate analysis, the independent FMD determinants in our study population were the presence of AF, smoking and total cholesterol levels (all p < 0.001). In patients with AF, the strongest independent FMD determinant was arrhythmia duration (p < 0.001), followed by smoking (p = 0.013) and total cholesterol levels (p = 0.045). Our findings confirm that sustained AF is associated with systemic endothelial dysfunction even in relatively young patients with no cardiovascular disorders or risk factors. AF is an independent contributor to lower FMD and a prolonged arrhythmia duration may confer the risk for more profound endothelial damage.

Serum (1→3)-β-D-Glucan Levels in HIV-Infected Individuals Are Associated With Immunosuppression, Inflammation, and Cardiopulmonary Function

Translocation of gastrointestinal bacteria in HIV-infected individuals is associated with systemic inflammation, HIV progression, mortality, and comorbidities. HIV-infected individuals are also susceptible to fungal infection and colonization, but whether fungal translocation occurs and influences HIV progression or comorbidities is unknown. Serum (1→3)-β-D-glucan (BG) was measured by a Limulus Amebocyte Lysate assay (Fungitell) in 132 HIV-infected outpatients. Selected plasma cytokines and markers of peripheral T-cell activation were measured. Pulmonary function testing and Doppler echocardiography were performed. Relationship of high (≥40 pg/mL) and low (<40 pg/mL) levels of BG with HIV-associated variables, inflammation markers, and pulmonary function and pulmonary hypertension measures were determined. Forty-eight percent of patients had detectable BG, and 16.7% had high levels. Individuals with high BG were more likely to have CD4 counts less than 200 cells/μL (31.8% vs. 8.4%, P = 0.002), had higher log10 HIV viral levels (2.85 vs. 2.13 log copies/mL, P = 0.004), and were less likely to use antiretroviral therapy (68.2% vs. 90.0%, P = 0.006). Plasma IL-8 (P = 0.033), TNF-α (P = 0.029), and CD8CD38 (P = 0.046) and CD8HLA-DR (P = 0.029) were also increased with high levels. Abnormalities in diffusing capacity (P = 0.041) and in pulmonary artery pressures (P = 0.006 for pulmonary artery systolic pressure and 0.013 for tricuspid regurgitant velocity) were more common in those with high BG. We found evidence of peripheral fungal cell wall polysaccharides in an HIV-infected cohort. We also demonstrated an association between high serum BG, HIV-associated immunosuppression, inflammation, and cardiopulmonary comorbidity. These results implicate a new class of pathogen in HIV-associated microbial translocation and suggest a role in HIV progression and comorbidities.