A large amount of organic waste is generated every year, mainly due to food waste, causing negative impacts on the environment. At the same time, cancer incidence and mortality are rapidly growing world-wide and have a great impact on patients' quality of life, especially during chemotherapy treatment. Therefore, the aim of this study was to develop a sustainable gelato with orange peel for cancer patients undergoing chemotherapy. The orange peel gelato developed presented protein content of high biological value, easily digested fat, low glycemic carbohydrate, phenolic and flavonoid content, and antioxidant potential. The orange peel may be used to develop sustainable gelato aiming to increase the intake of bioactive compounds in the general population, control chemotherapy symptoms of oncological patients and to contribute to the environment by reducing the generation of organic waste.