<h3>Purpose/Objective(s)</h3> Cervical brachytherapy (BT) is increasingly complex to execute, but critical to curing locally advanced cervical cancer (CC). BT has traditionally been learned one on one with experienced preceptors through direct care of patients. Research shows declining opportunities for radiation oncology residents to learn and practice BT for CC. How best to strengthen, accelerate, and democratize training in CC BT remains debatable. Virtual reality (VR) simulation has been demonstrated to be effective in enabling learners to acquire procedural skills with no risk to patient safety. This work elucidates the process of designing for more impactful BT procedural learning, leading to a novel immersive hands-on VR simulation for CC BT. <h3>Materials/Methods</h3> The concept-into-application process started with defining needs relative to technical and experiential CC BT learning, with practical considerations for trainees, clinicians, and administrative stakeholders. Multiple cycles of informal hands-on ideating, immersing and redefining, all key steps in design thinking, progressed for 18 months before actualization of a first-in-kind VR simulation prototype. CC BT guidelines-inspired learning outcomes were constructed following consultation with relevant domain experts. Detailed process mapping of an intracavitary/interstitial CC BT applicator insertion preceded drafting of a representative case vignette. 3-dimensional (3D) modelling of usual surgical instruments, and a next-generation BT applicator was done through computed tomography (CT) imaging, segmentation and postprocessing, to generate filmbox-format objects for use in the VR environment. The simulation was coded to mimic actual CC BT applicator insertion in an operating room. <h3>Results</h3> Optimized for headset/controllers but compatible with others, the simulation starts with the user facing a draped computer-generated patient and an instrument tray. Tasks are prompted, to be performed in proper sequence, and multiple-choice questions pop-ups, to be answered correctly, for the simulation completion. The simulation permits non-playing observers and may be paused or repeated at will. At the end of simulation, the user is informed of the standard post-procedural steps i.e., imaging for applicator position verification and planning. <h3>Conclusion</h3> A performance-oriented VR simulator for CC BT applicator insertion procedure has been developed as a first step in evolutionary prototyping towards a full-function BT instructional tool. VR remains an underutilized avenue in BT education despite the plethora of evidence demonstrating improved skill and knowledge acquisition with its use in other medical specialties. Further expansion of this innovative tool will entail establishing a case bank, incorporating imaging studies and performance metrics. Validation of the simulation as an educational tool is currently underway.