This article demonstrates empirical evidence on the spatial data analysis of the nexus between tourism and economic growth. South Europe’s regions during the time period 2000–2014 have been the case study of this work. The Generalized method of moments (GMM) approach used in this study enables testing the existence of determinants of regional economic status, while accounting for factors such as spatial interdependence. The empirical results reveal the existence of the significant conditional convergence hypothesis that is associated with the endogenous growth theory. Also, findings show that tourism and human capital supply seem to positively influence regional income.