X-ray imaging with computed tomography (CT) is widely used for nondestructive imaging of the interior of the human body. In the next decade, photon-counting X-ray CT is expected to reduce the dose needed and enable multicolor imaging. Recently, we proposed a novel photon-counting method that uses a multipixel photon counter (MPPC), with a significantly high signal gain (∼106) and fast temporal response (a few nanoseconds), combined with a high-speed scintillator. To realize photon-counting CT imaging in a wide area irradiated by an extremely high X-ray flux (106-107 Hz/mm2), a multichannel MPPC system is required. Thus, we developed a large-scale integrated circuit (LSI) with ultrafast signal-processing capability for use with a 16-channel MPPC. The developed LSI can extract a pulse current from an MPPC array with a large detector capacitance (∼200 pF) by utilizing an electrical circuit with low input impedance. The LSI offers a high photon count rate above 25 MHz/pixel with noise equal to 1.7 μA for a dynamic range of ∼ 1.3 mA and an energy resolution of 32 % (FWHM) at 60 keV, thereby enabling ultrafast multicolor CT imaging.