BACKGROUND: Mexican-origin men have the highest rates of non-alcoholic fatty liver disease (NAFLD) among men in the U.S. Current evidence regarding the effects of lifestyle behaviors and risk for NAFLD among Mexican-Origin men is scarce. PURPOSE: To assess the influence of lifestyle behaviors risk for NAFLD, in a sample of Mexican-origin men from the Cameron County Hispanic Cohort (CCHC). METHODS: The CCHC is a randomly selected cohort of community-dwelling Mexican Americans living in the U.S-Mexico border. Participants completed physical assessments and questionnaires on demographics, medical/medication use history, and lifestyle factors. Liver elastography (FibroScan®) was performed for the assessment of liver steatosis based on controlled attenuation parameters (CAP, dB/m) scores. Survey-based linear regression for CAP score or logistic regression analyses for mild steatosis (CAP ≥ 260) were conducted to examine the relationships of lifestyle and cardiometabolic factors to NAFLD. RESULTS: 207 Mexican-origin men (mean age: 53.5 (SE 2.5) years; mean BMI: 31.4±0.5. kg/m2; 43.9 % Spanish monolingual; 44.0 % born in U.S.) were included in the analysis. Mean CAP score was 290.4 (SE 7.3) dB/m and the prevalence of steatosis was 66.9% (SE 4.5%). There was no significant relationship of education, marital and uninsured status, smoking history, healthy/unhealthy eating indices, and physical activity levels to steatosis (p-values >0.05). There were significant associations between cardiometabolic risk factors including log transformed glucose OR= 8.20, 95%CI 1.63-41.25, p=0.0108), HbA1c (OR=1.43, 95%CI 1.08-1.90, p=0.013), HDL-C (OR=0.96, 95%CI 0.93-0.996, p=0.029) and log transformed triglyceride levels (OR=7.21, 95%CI 2.58-20.16 p<0.001), and steatosis. A one-unit increase in BMI was significantly associated with 36% increase in odds of steatosis (OR=1.36, 95%CI 1.18-1.55, p<0.001). Having metabolic syndrome (OR=4.93, 95%CI=1.84-13.19, p=0.0016) was significantly associated with steatosis in age-and BMI adjusted models. CONCLUSION: NAFLD was associated with cardiometabolic risk factors among Mexican-origin men in a community-based sample. Efforts to develop health promotion programs to address these risk factors, particularly body weight, are warranted.