Abstract
Non-alcoholic fatty liver disease (NAFLD) is defined as the condition of fat accumulation in the liver. This cross-sectional study aimed to investigate the relationship between body composition and fatty liver and determine of cut-off point for predicting NAFLD. Samples were selected from the nutrition clinic from 2016 to 2017 in Tehran, Iran. The liver steatosis was calculated using the CAP score through the FiroScan™ and body composition was measured using the dual-energy X-ray absorptiometry scan method. A total of 2160 patients participated in this study, 745 (34.5%) subjects had NAFLD. We found that fat-free tissue was inversely and fat tissue was directly correlated with the risk of NAFLD in almost all factors and the risk of developing NAFLD increases if the total fat exceeds 32.23% and 26.73% in women and men and abdominal fat exceeds 21.42% and 13.76% in women and men, respectively. Finally, we realized that the total fat percent had the highest AUC (0.932 for men and 0.917 for women) to predict the risk of NAFLD. Overall, the likelihood of NAFLD development rose significantly with increasing the amount of total fat and abdominal fat from the cut-off point level.
Highlights
Non-alcoholic fatty liver disease (NAFLD) is defined as the condition of fat accumulation in the liver with no history of extreme alcohol abuse (< 30 g/d in men and < 20 g/d in women) and in the absence of other liver diseases [1,2]
The present study aimed to investigate the relationship in different organs between body composition together with fatty liver in patients with NAFLD and the group without it, and determine a cut-off point based on total fat and abdominal fat, in Tehran, Iran
Our research investigates the relationship between NAFLD with body composition in an Iranian population
Summary
Non-alcoholic fatty liver disease (NAFLD) is defined as the condition of fat accumulation in the liver with no history of extreme alcohol abuse (< 30 g/d in men and < 20 g/d in women) and in the absence of other liver diseases [1,2]. The disease range varies from NAFLD to nonalcoholic steatohepatitis (NASH) [1]. NASH is a severe clinical form of NAFLD that has become one of the major causes of liver transplant [3].
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