The COVID-19 pandemic has significantly disrupted the circulation of influenza viruses in Kazakhstan, highlighting the vulnerabilities in the country’s public health infrastructure. This review critically examines the challenges faced in infiltrating and controlling influenza in Kazakhstan, particularly in light of the shifting epidemiological landscape post-pandemic. Key issues include the decline in influenza cases during the pandemic, which complicates the assessment of influenza epidemiology, vaccine effectiveness, and planning of vaccination campaigns. Although part of the Global Influenza Hospital Surveillance Network (GIHSN), Kazakhstan's surveillance systems face data collection, coordination, and public awareness gaps. The review discusses the prevalence of various influenza strains, the impact of zoonotic infections, and the necessity for improved monitoring frameworks. Additionally, the historical context of infectious disease control in Kazakhstan is explored, emphasising the need for enhanced international collaboration and targeted public health strategies. The findings underscore the importance of vaccination and robust surveillance to mitigate the risks of seasonal and pandemic influenza, advocating for a comprehensive approach to safeguard public health in Kazakhstan.