A comprehensive review of applying Taguchi’s optimization methodology to medical facilities was evaluated in this study. Taguchi’s optimization methodology is one kind of robust designation and is reputed for integrating multiple factors to pursue one goal. According to Taguchi’s suggestion, the efficient and reliable arrangement of experimental groups with numerous factors shortened the observed timing and provided bountiful statistical data. Although this method is widely used in mechanical, civil, and chemical engineering fields, it became adopted in medical facilities only in the last decade. Most of Taguchi’s analyses focused on optimizing the imaging quality for diagnosis. The medical facilities include regular X-ray, cardiac X-ray, CT (computed tomography), CTA (computed tomography angiography), LINAC (medical linear accelerator), or gamma camera scans. The images were all manipulated according to various radiation-induced interactions; thus, the optimization process of imaging resolution can offer an essential contribution to this kind of facility. In this study, we summarized the Taguchi-related papers in medical facilities and evaluated common principles in organizing the unique orthogonal array, assigning various signal-to-noise ratios, using quantified gauges, and ranking or grading the obtained imaging quality in the datum analysis process. The further elaboration on how to preset the user demanded goal in the optimization process, the necessity of focusing on cross interaction among factors, dynamic analysis superiority over static one preset in Taguchi’s analysis, and how to preset an ideal signal-to-noise ratio to satisfy the researcher demand, the importance of verification or testification in clinical cases or the assistance of ANOVA to depict a complete concept of applying Taguchi’s optimization methodology.